Differential expression and functional role of cannabinoid genes in alcohol users

Drug and Alcohol Dependence

Volumn 133, Issue 2, 2013, Pages 789-793

  Agudelo, Marisela ^a   Yndart, Adriana ^a   Morrison, Marisol ^a   Figueroa, Gloria ^a   Muñoz, Karla ^a   Samikkannu, Thangavel ^a   Nair, Madhavan P ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

Alcohol; Cannabinoid receptors; Cannabinoids; Human dendritic cells

Indexed keywords

ANTIBODY; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYTOKINE; ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; INTERLEUKIN 1BETA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALCOHOLISM; ARTICLE; CANNABINOID GENE; CELL FUNCTION; CLINICAL ARTICLE; CNR1 GENE; CNR2 GENE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; GPR55 GENE; HUMAN; HUMAN CELL; MONOCYTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ALCOHOL; CANNABINOID RECEPTORS; CANNABINOIDS; HUMAN DENDRITIC CELLS;

ADULT; ALCOHOLISM; CANNABINOIDS; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOKINES; DENDRITIC CELLS; ETHANOL; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; TRANSFECTION; YOUNG ADULT;

EID: 84887019867     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2013.08.023     Document Type: Article

References (34)

1. Agudelo M., Gandhi N., Saiyed Z., Pichili V., Thangavel S., Khatavkar P., Yndart-Arias A., Nair M. Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). Alcohol. Clin. Exp. Res. 2011, 35:1550-1556.
2. Agudelo M., Yoo C., Nair M.P. Alcohol-induced serotonergic modulation: the role of histone deacetylases. Alcohol 2012, 46:635-642.
3. Balenga N.A.B., Aflaki E., Kargl J., Platzer W., Schroder R., Blattermann S., Kostenis E., Brown A.J., Heinemann A., Waldhoer M. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res. 2011, 21:1452-1469.
4. Colombo G., Serra S., Brunetti G., Gomez R., Melis S., Vacca G., Carai M., Gessa G. Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats. Psychopharmacology (Berlin) 2002, 159:181-187.
5. Del Boca Fa., Noll J. Truth or consequences: the validity of self-report data in health services research on addictions. Addiction 2000, 95:S347-S360.
6. Erdozain A.M., Callado L.F. Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence. Drug Alcohol Depend. 2011, 117:102-110.
7. Foroud T., Edenberg H.J., Crabbe J.C. Who is at risk for alcoholism?. Alcohol Res. Health 2010, 33:64-75.
8. Freedland C.S., Sharpe A.L., Samson H.H., Porrino L.J. Effects of SR141716A on ethanol and sucrose self-administration. Alcohol. Clin. Exp. Res. 2001, 25:277-282.
9. Gaffuri A.L., Ladarre D., Lenkei Z. Type-1 cannabinoid receptor signaling in neuronal development. Pharmacology 2012, 90:19-39.
10. Gessa G.L., Serra S., Vacca G., Carai M.A.M., Colombo G. Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats. Alcohol Alcohol. 2005, 40:46-53.
11. Irving A. New blood brothers: the GPR55 and CB2 partnership. Cell Res. 2011, 21:1391-1392.
12. Kaplan B.L.F. The role of CB1 in immune modulation by cannabinoids. Pharmacol. Ther. 2012, 137:365-374.
13. Lippai D., Bala S., Petrasek J., Csak T., Levin I., Kurt-Jones E.A., Szabo G. Alcohol-induced IL-1B in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J. Leukoc. Biol. 2013, (Epub ahead of print).
14. Lu T., Newton C., Perkins I., Friedman H., Klein T.W. Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila. Infection 2006, 319:269-276.
15. Lu T., Newton C., Perkins I., Friedman H., Klein T.W. Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. Eur. J. Pharmacol. 2006, 532:170-177.
16. Marcos M., Pastor I., de la Calle C., Barrio-Real L., Laso F.-J., González-Sarmiento R. Cannabinoid receptor 1 gene is associated with alcohol dependence. Alcohol. Clin. Exp. Res. 2012, 36:267-271.
17. Mayfield J., Ferguson L., Harris R.A. Neuroimmune signaling: a key component of alcohol abuse. Curr. Opin. Neurobiol. 2013, (Epub ahead of print).
18. Mechoulam R., Parker L.A. The endocannabinoid system and the brain. Annu. Rev. Psychol. 2013, 64:21-47.
19. Miller A.M., Stella N. CB2 receptor-mediated migration of immune cells: it can go either way. Br. J. Pharmacol. 2008, 153:299-308.
20. Nair M., Reynolds J., Mahajan S., Schwartz S., Aalinkeel R., Bindukumar B., Sykes D. RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy. AAPS J. 2005, 7:E572-E578.
21. Nair M., Saiyed Z., Nair N., Gandhi N., Rodriguez J., Boukli N., Provencio-Vasquez E., Malow R., Miguez-Burbano M. Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells. J. Neuroimmune Pharmacol. 2009, 4:129-139.
22. Newton C.A., Lu T., Nazian S.J., Perkins I., Friedman H., Klein T.W. The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J. Leukoc. Biol. 2004, 76:854-861.
23. NIAAA Alcohol Across the Lifespan Five Year Strategic Plan FY07-11 2007, http://pubs.niaaa.nih.gov/publications/StrategicPlan/NIAAASTRATEGICPLAN.htm Accessed on 09.11.12.
24. Pacher P., Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system?. Prog. Lipid Res. 2011, 50:193-211.
25. Palmer R.H.C., McGeary J.E., Francazio S., Raphael B.J., Lander A.D., Heath A.C., Knopik V.S. The genetics of alcohol dependence: advancing towards systems-based approaches. Drug Alcohol Depend. 2012, 125:179-191.
26. Pava M.J., Woodward J.J. A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol 2012, 46:185-204.
27. Persidsky Y., Ho W., Ramirez S.H., Potula R., Abood M.E., Unterwald E., Tuma R. HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions. Brain Behav. Immun. 2011, 25(Suppl. 1):S61-S70.
28. Ramirez S.H., Haskó J., Skuba A., Fan S., Dykstra H., McCormick R., Reichenbach N., Krizbai I., Mahadevan A., Zhang M., Tuma R., Son Y.-J., Persidsky Y. Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood brain barrier dysfunction under inflammatory conditions. J. Neurosci. 2012, 32:4004-4016.
29. Rom S., Persidsky a.Y. Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation. J. Neuroimmune Pharmacol. 2013, 8:608-620.
30. Romero-Zerbo S.Y., Rafacho A., Díaz-Arteaga A., Suárez J., Quesada I., Imbernon M.n., Ross R.A., Dieguez C., Rodríguez de Fonseca F., Nogueiras R., Nadal A., Bermúdez-Silva F.J. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. J Endocrinol. 2011, 211(2):177-185.
31. Ryberg E., Larsson N., Sjögren S., Hjorth S., Hermansson N.O., Leonova J., Elebring T., Nilsson K., Drmota T., Greasley P.J. The orphan receptor GPR55 is a novel cannabinoid receptor. Br. J. Pharmacol. 2007, 152:1092-1101.
32. Schuckit M.A. An overview of genetic influences in alcoholism. J. Subst. Abuse Treat. 2009, 36:S5-S14.
33. Szabo G. Alcohol's contribution to compromised immunity. Alcohol Health Res. World 1997, 21:30-41.
34. Szabo G., Petrasek J., Bala S. Innate immunity and alcoholic liver disease. Dig. Dis. 2012, 30:55-60.