Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats

Alcohol and Alcoholism

Volumn 40, Issue 1, 2005, Pages 46-53

  Gessa, Gian Luigi ^a,b   Serra, Salvatore ^b   Vacca, Giovanni ^b   Carai, Mauro A M ^b   Colombo, Giancarlo ^a  

^a CNR   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 BROMOPHENYL) 1 (2,4 DICHLOROPHENYL) 4 ETHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ALCOHOL; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; RIMONABANT; UNCLASSIFIED DRUG;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; MALE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; TASTE AVERSION;

ALCOHOL DRINKING; ANALYSIS OF VARIANCE; ANIMALS; ETHANOL; MALE; MOTIVATION; PIPERIDINES; PYRAZOLES; RATS; RECEPTOR, CANNABINOID, CB1; RECURRENCE; SELF ADMINISTRATION; TEMPERANCE; TIME FACTORS;

EID: 12544253479     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/alcalc/agh114     Document Type: Article

References (31)

1. Agabio, R., Carai, M. A. M., Lobina, C., Pani, M., Reali, R., Vacca, G., Gessa, G. L. and Colombo, G. (2000) Development of short-lasting alcohol deprivation effect (ADE) in Sardinian alcohol-preferring rats. Alcohol 21, 59-62.
2. Arnone, M., Maruani, J., Chaperon, F., Thiébot, M. E., Poncelet, M., Soubrié, P. and Le Fur, G. (1997) Selective inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology 132, 104-106.
3. Boening, J. A. L., Lesch, O. M., Spanagel, R., Wolffgramm, J., Narita, M., Sinclair, D., Mason, B. J. and Wiesbeck, G. A. (2001) Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism: Clinical and Experimental Research 25, S127-131.
4. Broadbent, J., Linder, H. V. and Cunningham, C. L. (1996) Genetic differences in naloxone enhancement of ethanol-induced conditioned taste aversion. Psychopharmacology 126, 147-155.
5. Brunetti, G., Carai, M. A. M., Lobina, C., Melis, S., Serra, S., Vacca, G., Gessa, G. L. and Colombo, G. (2002) Differences in ethanol-induced conditioned taste aversion in Sardinian alcohol-preferring and Sardinian alcohol-nonpreferring rats. Alcohol 26, 167-172.
6. Colombo, G., Agabio, R., Fà, M., Guano, L., Lobina, C., Loche, A., Reali, R. and Gessa, G. L. (1998) Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR 141716. Alcohol and Alcoholism 33, 126-130.
7. Colombo, G., Agabio, R., Carai, M. A. M., Lobina, C., Pani, M., Reali, R., Addolorato, G. and Gessa, G. L. (2000) Ability of baclofen in reducing alcohol intake and withdrawal severity: I - preclinical evidence. Alcoholism: Clinical and Experimental Research 24, 58-66.
8. B receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats. Alcohol and Alcoholism 37, 499-503.
9. Colombo, G., Serra, S., Brunetti, G., Gomez, R., Melis, S., Vacca, G., Carai, M. A. M. and Gessa, G. L. (2002b) Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats. Psychopharmacology 159, 181-187.
10. 1 receptor antagonist, SR141716, on alcohol's motivational properties in alcohol-preferring rats. European Journal of Pharmacology, 498 119-123.
11. Freedland, C. S., Sharpe, A. L., Samson, H. H. and Porrino, L. J. (2001) Effects of SR1417161A on ethanol and sucrose self-administration. Alcoholism: Clinical and Experimental Research 25, 277-282.
12. Gallate, J. E. and McGregor, I. S. (1999) The motivation for beer in rats: effects of ritanserin, naloxone and SR141716. Psychopharmacology 142, 302-308.
13. 1 receptor agonist. European Journal of Pharmacology 370, 233-240.
14. 1 receptor knockout exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens. Journal of Neurochemistry 84 698-704.
15. Lallemand, F. and De Witte, P. H. (2004) Ethanol induces higher BEC in CB1 cannabinoid receptor knockout mice while decreasing ethanol preference. Alcohol and Alcoholism, in press.
16. 1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration. Alcoholism: Clinical and Experimental Research 25, 1317-1323.
17. Morse, R. M. and Flavin, D. K. (1992) The definition of alcoholism. Journal of American Medical Association 268, 1012-1014.
18. Naassila, M., Pierrefiche, O., Ledent, C. and Daoust, M. (2004) Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. Neuropharmacology 46, 243-253.
19. 1 receptor deleted mice. Neuroscience Letters 343, 216-218.
20. 1 receptors in alcohol dependence and stress-stimulated ethanol drinking. Journal of Neuroscience 23, 2453-2458.
21. Rinaldi-Carmona, M., Barth, F., Héauime, M. et al. (1994) SR141716A, a potent and selective antagonist of the cannabinoid receptor. FEBS Letters 350, 240-244.
22. Rinaldi-Carmona, M., Barth, F., Congy, C. et al. (2004) SR147778, a new potent and selective antagonist of the CB1 cannabinoid receptor. Biochemical and pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics 310, 905-914.
23. 3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol 21, 73-85.
24. Samson, H. H. (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcoholism: Clinical and Experimental Research 10, 436-442.
25. Samson, H. H., Chappell, A., Czachowski, C. and Sharpe, A. (2001) Measuring ethanol-seeking behavior: the effect of using repeated extinction trials. Alcohol 24, 205-209.
26. Samson, H. H., Czachowski, C. L., Chappell, A. and Legg, B. (2003) Measuring the appetite strength of ethanol: use of an extinction trial procedure. Alcohol 31, 77-86.
27. Serra, S., Carai, M. A. M., Brunetti, G., Gomez, R., Melis, S., Vacca, G., Colombo, G. and Gessa, G. L. (2001) The cannabinoid receptor antagonist SR141716 prevents acquisition of drinking behaviour in alcohol-preferring rats. European Journal of Pharmacology 430 369-371.
28. 1 receptor antagonist, SR141716, of alcohol deprivation effect in alcohol-prefening rats. European Journal of Pharmacology 443, 95-97.
29. Serra, S., Brunetti, G., Vacca, G., Lobina, C., Carai, M. A. M., Gessa, G. L. and Colombo, G. (2003) Stable preference for high ethanol concentrations after alcohol deprivation in Sardinian alcohol-preferring (sP) rats. Alcohol 29, 101-108.
30. Wang, L., Liu, J., Harvey-White, J., Zimmer, A. and Kunos, G. (2003) Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proceedings of the National Academy of Sciences of the United States of America 100, 1393-1398.
31. Williams, K. L. and Woods, J. H. (1999) Conditioned effects produced by naltrexone doses that reduce ethanol-reinforced responding in rhesus monkeys. Alcoholism: Clinical and Experimental Research 23, 708-715.