RNAi-directed inhibition of DC-SIGN by dendritic cells: Prospects for HIV-1 therapy

AAPS Journal

Volumn 7, Issue 3, 2005, Pages

  Nair, Madhavan P N ^a   Reynolds, Jessica L ^a   Mahajan, Supriya D ^a   Schwartz, Stanley A ^a   Aalinkeel, Ravikumar ^a   Bindukumar, B ^a   Sykes, Don ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Co stimulatory molecules; DC SIGN; Dendritic cells; HIV 1; HIV LTR U5; MAPK; siRNA

Indexed keywords

DOUBLE STRANDED RNA; HELICASE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEASE; SMALL INTERFERING RNA; CD209 ANTIGEN; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; DC-SPECIFIC ICAM-3 GRABBING NONINTEGRIN; LECTIN;

ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DRUG SYNTHESIS; GENE EXPRESSION; GENE TARGETING; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NORTH AMERICA; NUCLEOTIDE SEQUENCE; POSTTRANSCRIPTIONAL GENE SILENCING; RNA DEGRADATION; RNA EXTRACTION; RNA INTERFERENCE; RNA SEQUENCE; TREATMENT FAILURE; VIRUS GENOME; VIRUS INHIBITION; VIRUS ISOLATION; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; VIROLOGY;

CELL ADHESION MOLECULES; CELLS, CULTURED; DENDRITIC CELLS; HIV INFECTIONS; HIV-1; HUMANS; LECTINS, C-TYPE; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING;

EID: 33644805339     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070358     Document Type: Article

References (38)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-811.
2. Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA. 2001;98:9742-9747.
3. Clemens JC, Worby CA, Simonson-Leff N, et al. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci USA. 2000;97:6499-6503.
4. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAS mediate RNA interference in cultured mammalian cells. Nature. 2001;411:494-498.
5. Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 2001;15:188-200.
6. Bass BL. Double-stranded RNA as a template for gene silencing. Cell. 2000;101:235-238.
7. Hamilton AJ, Baulcombe DC. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science. 1999;286:950-952.
8. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000;101:25-33.
9. Sodroski J, Patarca R, Rosen C, Wong-Staal F, Haseltine W. Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science. 1985;229:74-77.
10. Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature. 2002;418:435-438.
11. Coburn GA, Cullen BR. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol. 2002;76:9225-9231.
12. Novina CD, Murray MF, Dykxhoorn DM, et al. siRNA-directed inhibition of HIV-1 infection. Nat Med. 2002;8:681-686.
13. Park WS, Miyano-Kurosaki N, Hayafune M, et al. Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference. Nucleic Acids Res. 2002;30:4830-4835.
14. Hu WY, Bushman FD, Siva AC. RNA interference against retroviruses. Virus Res. 2004;102:59-64.
15. Anderson J, Banerjea A, Akkina R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides. 2003;13:303-312.
16. Anderson J, Banerjea A, Planelles V, Akkina R. Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA. AIDS Res Hum Retroviruses. 2003;19:699-706.
17. Martinez MA, Gutierrez A, Armand-Ugon M, et al. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS. 2002;16:2385-2390.
18. Qin XF, An DS, Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA. 2003;100:183-188.
19. Cordelier P, Morse B, Strayer DS. Targeting CCR5 with siRNAs: using recombinant SV40-derived vectors to protect macrophages and microglia from R5-tropic HIV. Oligonucleotides. 2003;13:281-294.
20. Arrighi JF, Pion M, Garcia E, et al. DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J Exp Med. 2004;200:1279-1288.
21. Arrighi JF, Pion M, Wiznerowicz M, et al. Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells. J Virol. 2004;78:10848-10855.
22. Smithgall MD, Wong JG, Linsley PS, Haffar OK. Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro. AIDS Res Hum Retroviruses. 1995;11:885-892.
23. Hiscott J, Kwon H, Genin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest. 2001;107:143-151.
24. Dauer M, Obermaier B, Herten J, et al. Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors. J Immunol. 2003;170:4069-4076.
25. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
26. Shively L, Chang L, LeBon JM, Liu Q, Riggs AD, Singer-Sam J. Real-time PCR assay for quantitative mismatch detection. Biotechniques. 2003;34:498-502, 504.
27. Secchiero P, Zella D, Curreli S, et al. Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells. J Immunol. 2000;164:4018-4024.
28. Bashirova AA, Wu L, Cheng J, Kewal-Ramani VN, Hughes A, Carrington M. Novel member of the CD209 (DC-SIGN) gene family in primates. J Virol. 2003;77:217-227.
29. Steinman RM, Young JW. Signals arising from antigen-presenting cells. Curr Opin Immunol. 1991;3:361-372.
30. Steinman RM. DC-SIGN: a guide to some mysteries of dendritic cells. Cell. 2000;100:491-494.
31. Bender A, Sapp M, Schuler G, Steinman RM, Bhardwaj N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods. 1996;196:121-135.
32. Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 1997;388:782-787.
33. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood, J Exp Med. 1994;180:83-93.
34. Granelli-Piperno A, Delgado E, Finkel V, Paxton W, Steinman RM. Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells. J Virol. 1998;72:2733-2737.
35. Cameron P, Pope M, Granelli-Piperno A, Steinman RM. Dendritic cells and the replication of HIV-1. J Leukoc Biol. 1996;59:158-171.
36. Frank I, Kacani L, Stoiber H, et al. Human immunodeficiency virus type 1 derived from cocultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious. J Virol. 1999;73:3449-3454.
37. Ganesh L, Leung K, Lore K, et al. Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies. J Virol. 2004;78:11980-11987.
38. Nair MPN, Mahajan SD, Schwartz SA, et al. Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients. J Immunol. 2005;174:6617-6626.