High NOTCH activity induces radiation resistance in non small cell lung cancer

Radiotherapy and Oncology

Volumn 108, Issue 3, 2013, Pages 440-445

  Theys, Jan ^a   Yahyanejad, Sanaz ^a   Habets, Roger ^a   Span, Paul ^b   Dubois, Ludwig ^a   Paesmans, Kim ^a   Kattenbeld, Bo ^b   Cleutjens, Jack ^c   Groot, Arjan J ^a   Schuurbiers, Olga C J ^b   Lambin, Philippe ^a   Bussink, Jan ^b   Vooijs, Marc ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hypoxia; NOTCH; NSCLC; Radiation

Indexed keywords

NOTCH RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CELL ASSAY; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

HYPOXIA; NOTCH; NSCLC; RADIATION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LUNG NEOPLASMS; MICE; RADIATION TOLERANCE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84887019124     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.020     Document Type: Article

References (27)

1. D. De Ruysscher, J. Belderbos, and B. Reymen State of the art radiation therapy for lung cancer 2012: a glimpse of the future Clin Lung Cancer 14 2013 89 95
2. S. Artavanis-Tsakonas, and M. Muskavitch Notch: the past, the present, and the future Curr Top Dev Biol 92 2010 1 29
3. L. Miele, T. Golde, and B. Osborne Notch signaling in cancer Curr Mol Med 6 2006 905 918
4. M. Morimoto, R. Nishinakamura, Y. Saga, and R. Kopan Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells Development 139 2012 4365 4373
5. P. Ranganathan, K. Weaver, and A. Capobianco Notch signalling in solid tumours: a little bit of everything but not all the time Nat Rev Cancer 11 2011 338 351
6. B. Westhoff, I.N. Colaluca, and G. D'Ario Alterations of the Notch pathway in lung cancer Proc Natl Acad Sci USA 106 2009 22293 22298
7. T. Donnem, S. Andersen, K. Al-Shibli, S. Al-Saad, L.-T. Busund, and R. Bremnes Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival Cancer 116 2010 5676 5685
8. A. Baumgart, S. Seidl, and P. Vlachou ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer Cancer Res 70 2010 5368 5378
9. O.J. De La, L.L. Emerson, and J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci USA 105 2008 18907 18912
10. Lei Sun, Stephanie M. Cabarcas, and William L. Farrar Radioresistance and cancer stem cells: survival of the fittest Carcinogen Mutagen 2011 21 81
11. J. Wang, T.P. Wakeman, and J.D. Lathia Notch promotes radioresistance of glioma stem cells Stem Cells 28 2010 17 28
12. T.W. Meijer, O.C. Schuurbiers, and J.H. Kaanders Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4 Lung Cancer 76 2012 316 323
13. J. Theys, B. Jutten, and R. Habets E-cadherin loss associated with EMT promotes radioresistance in human tumor cells Radiother Oncol 99 2011 392 397
14. A. Weng, Y. Nam, and M. Wolfe Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling Mol Cell Biol 23 2003 655 664
15. G. van Tetering, N. Bovenschen, J. Meeldijk, P.J. van Diest, and M. Vooijs Cleavage of Notch1 by granzyme B disables its transcriptional activity Biochem J 437 2011 313 322
16. J. Theys, B. Jutten, and L. Dubois The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment Radiother Oncol 92 2009 399 404
17. S. Weppler, Y. Li, and L. Dubois Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance Radiother Oncol 83 2007 333 339
18. S. Suwanjunee, W. Wongchana, and T. Palaga Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling Anticancer Drugs 19 2008 477 486
19. B. Martin, M. Paesmans, and C. Mascaux Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis Br J Cancer 91 2004 2018 2025
20. H. Diez, A. Fischer, and A. Winkler Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate Exp Cell Res 313 2007 1 9
21. S. Liu, S. Bham, and E. Fokas Delta-like ligand 4-notch blockade and tumor radiation response J Natl Cancer Inst 103 2011 1778 1798
22. S. Eliasz, S. Liang, and Y. Chen Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway Oncogene 29 2010 2488 2498
23. C. Sahlgren, M.V. Gustafsson, S. Jin, L. Poellinger, and U. Lendahl Notch signaling mediates hypoxia-induced tumor cell migration and invasion Proc Natl Acad Sci USA 105 2008 6392 6397
24. B. Keith, and M.C. Simon Hypoxia-inducible factors, stem cells, and cancer Cell 129 2007 465 472
25. J.P. Sullivan, J.D. Minna, and J.W. Shay Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy Cancer Metastasis Rev 29 2010 61 72
26. G. Bertolini, L. Roz, and P. Perego Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment Proc Natl Acad Sci USA 106 2009 16281 16286
27. J. Domingo-Domenech, S.J. Vidal, and V. Rodriguez-Bravo Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells Cancer Cell 22 2012 373 388