Small molecule fusion inhibitors: Design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3- carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 23, 2013, Pages 7539-7548

  He, Xiao Yang ^a,e   Lu, Lu ^b   Qiu, Jiayin ^c   Zou, Peng ^d   Yu, Fei ^b,c,d   Jiang, Xing Kai ^a   Li, Lin ^c   Jiang, Shibo ^b,d   Liu, Shuwen ^c   Xie, Lan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b FUDAN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d NEW YORK BLOOD CENTER   (United States)

^e BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

3 Substituted N (3 carboxy 4 hydroxy)phenyl 2,5 dimethylpyrrole derivatives; Anti HIV agents; HIV 1 gp41; Small molecule fusion inhibitors

Indexed keywords

2,5 DIOXO 1 PHENETHYLPYRROLIDIN 3 YL ACETATE; 3 [5 (3 BENZYL 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE)METHYL] N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYLPYRROLE; 3 [5 [3 (3 BROMOBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL] N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYLPYRROLE; 3 [5 [3 (4 BROMOBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL] N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYLPYRROLE; 3 [5 [3 (4 CARBONYLBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL] N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYLPYRROLE; 3 [5 [3 (4 TERT BUTYLBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL] N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYLPYRROLE; 3 BENZYLTHIAZOLIN 2,4 DIONE; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; N (3 CARBOXY 4 CHLORO)PHENYL 2,5 DIMETHYL 3 FORMYLPYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 (4 OXO 3 PHENYL 2 THIOXOTHIAZOLIDINYLIDENE)METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [3 (3 METHOXYBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [3 (4 METHOXYBENZYL) 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [3 (4 TRIFLUOROMETHYLBENZYL)4 OXO 3 PHENYL 2 THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [3 [3 (METHOXYCARBONYL)BENZYL] 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [3 [4 (METHOXYCARBONYL)BENZYL] 4 OXO 2 THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY 4 HYDROXY)PHENYL 2,5 DIMETHYL 3 [5 [4 OXO 2 THIOXO 3 (3 TRIFLUOROMETHYLBENZYL)THIOXOTHIAZOLIDINYLIDENE]METHYL]PYRROLE; N (3 CARBOXY)PHENYL 2,5 DIMETHYL 3 FORMYLPYRROLE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

3-SUBSTITUTED N-(3-CARBOXY-4-HYDROXY)PHENYL-2,5-DIMETHYLPYRROLE DERIVATIVES; ANTI-HIV AGENTS; HIV-1 GP41; SMALL-MOLECULE FUSION INHIBITORS;

ANTI-HIV AGENTS; CELL LINE; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; PYRROLES; SMALL MOLECULE LIBRARIES;

EID: 84886950938     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.046     Document Type: Article

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