Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6447-6454

  Chen, Jian Jeffrey ^a   Qian, Wenyuan ^a   Biswas, Kaustav ^a   Yuan, Chester ^a   Amegadzie, Albert ^a   Liu, Qingyian ^a   Nixey, Thomas ^a   Zhu, Joe ^a   Ncube, Mqhele ^a   Rzasa, Robert M ^a   Chavez, Frank ^a   Chen, Ning ^a   Demorin, Frenel ^a   Rumfelt, Shannon ^a   Tegley, Christopher M ^a   Allen, Jennifer R ^a   Hitchcock, Stephen ^a   Hungate, Randy ^a   Bartberger, Michael D ^a   Zalameda, Leeanne ^a   Liu, Yichin ^a   McCarter, John D ^a   Zhang, Jianhua ^a   Zhu, Li ^a   Babu Khan, Safura ^a   Luo, Yi ^a   Bradley, Jodi ^a   Wen, Paul H ^a   Reid, Darren L ^a   Koegler, Frank ^a   Dean, Charles ^a   Hickman, Dean ^a   Correll, Tiffany L ^a   Williamson, Toni ^a   Wood, Stephen ^a   more..

^a AMGEN INC   (United States)

Author keywords

Alzheimer's disease (AD); Amide as sulfonamide replacement; Amyloid protein (A ); Methylpyridine; Secretase inhibitor (GSI); Secretase modulator (GSM)

Indexed keywords

2 METHYLPYRIDINE BIARYL AMIDE DERIVATIVE; AMIDE; AMYLOID BETA PROTEIN[1-42]; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GAMMA SECRETASE; MULTIENZYME COMPLEX; PYRIDINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HOMOGENATE; CEREBROSPINAL FLUID; CIRCULAR DICHROISM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; STEREOCHEMISTRY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TREATMENT OUTCOME;

RATTUS;

ALZHEIMER'S DISEASE (AD); AMIDE AS SULFONAMIDE REPLACEMENT; AMYLOID Β-PROTEIN (AΒ); METHYLPYRIDINE; Γ-SECRETASE INHIBITOR (GSI); Γ-SECRETASE MODULATOR (GSM);

ALZHEIMER DISEASE; AMIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HEK293 CELLS; HUMANS; PICOLINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84886947730     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.041     Document Type: Article

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