SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4832-4835

Pyridine-derived γ-secretase modulators

(26) Wan, Zehong a Hall, Adrian a Sang, Yingxia a Xiang, Jia Ning a Yang, Eric a Smith, Beverley a Harrison, David C a Yang, Guang a Yu, Haihua a Price, Helen S a Wang, Jian a Hawkins, Julie a Lau, Lit Fui a Johnson, Matthew R a Li, Tina a Zhao, Wei a Mitchell, William L a Su, Xiaobo a Zhang, Xiaomin a Zhou, Yanjiao a more..

a GLAXOSMITHKLINE (China)

Author keywords

Secretase inhibitor; Secretase modulator; Pyridine; SAR

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE MODULATOR; NOTCH RECEPTOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN CONTENT; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; RAT;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PYRIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960921944 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.042 Document Type: Article

Times cited : (18)

References (20)

1
- 0037380697
- T.E. Golde J. Clin. Invest. 111 2003 1
- (2003) J. Clin. Invest. , vol.111 , pp. 1
- Golde, T.E.¹

2
- 72249104807
- H.H. Griffiths, I. Morten, and N.M. Hooper Expert Opin. Ther. 12 2008 704
- (2008) Expert Opin. Ther. , vol.12 , pp. 704
- Griffiths, H.H.¹ Morten, I.² Hooper, N.M.³

3
- 0030669036
- D.W. Dickson J. Neuropathol. Exp. Neurol. 56 1997 321
- (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 321
- Dickson, D.W.¹

4
- 0006164301
- I.G. McKeith, D. Galasko, K. Kosaka, E.K. Perry, D.W. Dickson, L.A. Hansen, D.P. Salmon, J. Lowe, S.S. Mirra, E.J. Byrne, G. Lennox, N.P. Quinn, J.A. Edwardson, P.G. Ince, C. Bergeron, A. Burns, B.L. Miller, S. Lovestone, D. Collerton, E.N. Jansen, C. Ballard, R.A. de Vos, G.K. Wilcock, K.A. Jellinger, and R.H. Perry Neurology 47 1996 1113
- (1996) Neurology , vol.47 , pp. 1113
- McKeith, I.G.¹ Galasko, D.² Kosaka, K.³ Perry, E.K.⁴ Dickson, D.W.⁵ Hansen, L.A.⁶ Salmon, D.P.⁷ Lowe, J.⁸ Mirra, S.S.⁹ Byrne, E.J.¹⁰ Lennox, G.¹¹ Quinn, N.P.¹² Edwardson, J.A.¹³ Ince, P.G.¹⁴ Bergeron, C.¹⁵ Burns, A.¹⁶ Miller, B.L.¹⁷ Lovestone, S.¹⁸ Collerton, D.¹⁹ Jansen, E.N.²⁰ more..

5
- 33748584602
- P.K. Mandal, J.W. Pettegrew, E. Masliah, R.L. Hamilton, and R. Mandal Neurochem. Res. 31 2006 1153
- (2006) Neurochem. Res. , vol.31 , pp. 1153
- Mandal, P.K.¹ Pettegrew, J.W.² Masliah, E.³ Hamilton, R.L.⁴ Mandal, R.⁵

6
- 34548543292
- H. Laudon, B. Winbald, and J. Näslund Physiol. Behav. 92 2007 115
- (2007) Physiol. Behav. , vol.92 , pp. 115
- Laudon, H.¹ Winbald, B.² Näslund, J.³

7
- 36749062430
- Y. Zhang, and H. Xu Curr. Mol. Med. 7 2007 687
- (2007) Curr. Mol. Med. , vol.7 , pp. 687
- Zhang, Y.¹ Xu, H.²

8
- 0035163347
- H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, A.P. de Saint, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholodenko, J.E. Knops, L.H. Latimer, M. Lee, Z. Liao, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. eckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W.Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, and J.E. Audia J. Neurochem. 76 2001 173
- (2001) J. Neurochem. , vol.76 , pp. 173
- Dovey, H.F.¹ John, V.² Anderson, J.P.³ Chen, L.Z.⁴ De Saint, A.P.⁵ Fang, L.Y.⁶ Freedman, S.B.⁷ Folmer, B.⁸ Goldbach, E.⁹ Holsztynska, E.J.¹⁰ Hu, K.L.¹¹ Johnson-Wood, K.L.¹² Kennedy, S.L.¹³ Kholodenko, D.¹⁴ Knops, J.E.¹⁵ Latimer, L.H.¹⁶ Lee, M.¹⁷ Liao, Z.¹⁸ Lieberburg, I.M.¹⁹ Motter, R.N.²⁰ more..

9
- 11144354609
- C.A. Saura, S.Y. Choi, V. Beglopoulos, S. Malkani, D. Zhang, B.S. Shankaranarayana-Rao, S. Chattarji, R.J. Kelleher 3rd., E.R. Kandel, K. Duff, A. Kirkwood, and J. Shen Neuron 8 2004 23
- (2004) Neuron , vol.8 , pp. 23
- Saura, C.A.¹ Choi, S.Y.² Beglopoulos, V.³ Malkani, S.⁴ Zhang, D.⁵ Shankaranarayana-Rao, B.S.⁶ Chattarji, S.⁷ Kelleher III, R.J.⁸ Kandel, E.R.⁹ Duff, K.¹⁰ Kirkwood, A.¹¹ Shen, J.¹²

10
- 35148844224
- T. Li, H. Wen, C. Brayton, F.M. Laird, G. Ma, S. Peng, L. Placanica, T.C. Wu, B.J. Crain, D.L. Price, C.G. Eberhart, and P.C. Wong J. Neurosci. 27 2007 10849
- (2007) J. Neurosci. , vol.27 , pp. 10849
- Li, T.¹ Wen, H.² Brayton, C.³ Laird, F.M.⁴ Ma, G.⁵ Peng, S.⁶ Placanica, L.⁷ Wu, T.C.⁸ Crain, B.J.⁹ Price, D.L.¹⁰ Eberhart, C.G.¹¹ Wong, P.C.¹²

11
- 0033775709
- A. Herreman, L. Serneels, W. Annaert, D. Collen, L. Schoonjans, and S.B. De Nat. Cell Biol. 2 2000 461
- (2000) Nat. Cell Biol. , vol.2 , pp. 461
- Herreman, A.¹ Serneels, L.² Annaert, W.³ Collen, D.⁴ Schoonjans, L.⁵ De, S.B.⁶

12
- 24644494243
- B.Z. Stanger, R. Datar, L.C. Murtaugh, and D.A. Melton Proc. Natl. Acad. Sci. 102 2005 12443
- (2005) Proc. Natl. Acad. Sci. , vol.102 , pp. 12443
- Stanger, B.Z.¹ Datar, R.² Murtaugh, L.C.³ Melton, D.A.⁴

13
- 11144355129
- G.T. Wong, D. Manfra, F.M. Poulet, Q. Zhang, H. Josien, T. Bara, L. Engstrom, M. Pinzon-Ortiz, J.S. Fine, H.J. Lee, L. Zhang, G.A. Higgins, and E.M. Parker J. Biol. Chem. 279 2004 12876
- (2004) J. Biol. Chem. , vol.279 , pp. 12876
- Wong, G.T.¹ Manfra, D.² Poulet, F.M.³ Zhang, Q.⁴ Josien, H.⁵ Bara, T.⁶ Engstrom, L.⁷ Pinzon-Ortiz, M.⁸ Fine, J.S.⁹ Lee, H.J.¹⁰ Zhang, L.¹¹ Higgins, G.A.¹² Parker, E.M.¹³

14
- 47749107571
- E. Czirr, B.A. Cottrell, S. Leuchtenberger, T. Kukar, T.B. Ladd, H. Esselmann, S. Paul, R. Schubenel, J.W. Torpey, C.U. Pietrzik, T.E. Golde, J. Wiltfang, K. Baumann, E.H. Koo, and S. Weggen J. Biol Chem 283 2008 17049
- (2008) J. Biol Chem , vol.283 , pp. 17049
- Czirr, E.¹ Cottrell, B.A.² Leuchtenberger, S.³ Kukar, T.⁴ Ladd, T.B.⁵ Esselmann, H.⁶ Paul, S.⁷ Schubenel, R.⁸ Torpey, J.W.⁹ Pietrzik, C.U.¹⁰ Golde, T.E.¹¹ Wiltfang, J.¹² Baumann, K.¹³ Koo, E.H.¹⁴ Weggen, S.¹⁵

15
- 40349106236
- I. Peretto, and P.E. La Curr. Top. Med. Chem. 8 2008 38
- (2008) Curr. Top. Med. Chem. , vol.8 , pp. 38
- Peretto, I.¹ La, P.E.²

16
- 74049139969
- A. Hall, R.L. Elliott, G.M. Giblin, I. Hussain, J. Musgrave, A. Naylor, R. Sasse, and B. Smith Bioorg. Med. Chem. Lett. 20 2010 1306
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1306
- Hall, A.¹ Elliott, R.L.² Giblin, G.M.³ Hussain, I.⁴ Musgrave, J.⁵ Naylor, A.⁶ Sasse, R.⁷ Smith, B.⁸

17
- 77956311201
- M.Z. Kounnas, A.M. Danks, S. Cheng, C. Tyree, E. Ackerman, X. Zhang, K. Ahn, P. Nguyen, D. Comer, L. Mao, C. Yu, D. Pleynet, P.J. Digregorio, G. Velicelebi, K.A. Stauderman, W.T. Comer, W.C. Mobley, Y. Li, S.S. Sisodia, R.E. Tanzi, and S.L. Wagner Neuron 67 2010 769
- (2010) Neuron , vol.67 , pp. 769
- Kounnas, M.Z.¹ Danks, A.M.² Cheng, S.³ Tyree, C.⁴ Ackerman, E.⁵ Zhang, X.⁶ Ahn, K.⁷ Nguyen, P.⁸ Comer, D.⁹ Mao, L.¹⁰ Yu, C.¹¹ Pleynet, D.¹² Digregorio, P.J.¹³ Velicelebi, G.¹⁴ Stauderman, K.A.¹⁵ Comer, W.T.¹⁶ Mobley, W.C.¹⁷ Li, Y.¹⁸ Sisodia, S.S.¹⁹ Tanzi, R.E.²⁰ Wagner, S.L.²¹ more..

18
- 79960915972
- PCT 2007, WO 2007/058304
- Kushida, I.; Doi, E.; Ito, K.; Nakamura, T. PCT 2007, WO 2007/058304.
- Kushida, I.¹ Doi, E.² Ito, K.³ Nakamura, T.⁴

19
- 79851473226
- D. Oehlrich, D.J.-C. Berthelot, and H.J.M. Gijsen J. Med. Chem. 54 2011 669
- (2011) J. Med. Chem. , vol.54 , pp. 669
- Oehlrich, D.¹ Berthelot, D.J.-C.² Gijsen, H.J.M.³

20
- 79960917099
- doi:10.106/j.bmcl.2011.04.143
- Z. Wan, A. Hall, Y. Jin, J. Xiang, E. Yang, A. Eatherton, B. Smith, G. Yang, H. Yu, J. Wang, L. Ye, L. Lau, T. Yang, W. Mitchell, W. Cai, X. Zhang, Y. Sang, Y. Wang, Z. Tong, Z. Cheng, I. Hussain, J.D. Elliott, and Y. Matsuoka Bioorg. Med. Chem. Lett. 2011 doi:10.106/j.bmcl.2011.04.143
- (2011) Bioorg. Med. Chem. Lett.
- Wan, Z.¹ Hall, A.² Jin, Y.³ Xiang, J.⁴ Yang, E.⁵ Eatherton, A.⁶ Smith, B.⁷ Yang, G.⁸ Yu, H.⁹ Wang, J.¹⁰ Ye, L.¹¹ Lau, L.¹² Yang, T.¹³ Mitchell, W.¹⁴ Cai, W.¹⁵ Zhang, X.¹⁶ Sang, Y.¹⁷ Wang, Y.¹⁸ Tong, Z.¹⁹ Cheng, Z.²⁰ more..

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.