Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 23, 2013, Pages 7406-7417

  Sun, Yang ^a   Chen, Jianwen ^a   Chen, Xuemin ^b   Huang, Ling ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Shenzhen Salubris Pharmaceuticals Co Ltd   (China)

Author keywords

Alzheimer's disease; Cholinesterase; Monoamine oxidase B

Indexed keywords

3 (2 METHOXYBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (3 METHOXYBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (3,4 DIMETHOXYBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 CHLOROBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 FLUOROBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 7 [10 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 7 [5 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 7 [8 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHOXYBENZYLIDENE) 7 [9 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 (4 METHYLBENZYLIDENE) 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 [4 (DIETHYLAMINO)BENZYLIDENE] 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 3 [4 (DIMETHYLAMINO)BENZYLIDENE] 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PENTYLOXY]CHROMAN 4 ONE; 4 CHROMANONE DERIVATIVE; 7 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLOXY] 3 (3,4,5 TRIMETHOXYBENZYLIDENE)CHROMAN 4 ONE; 7 [6 (6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLOXY] 3 (3,4,5 TRIMETHOXYBENZYLIDENE)CHROMAN 4 ONE; 7 HYDROXY 3 (4 METHOXYBENZYLIDENE)CHROMAN 4 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CARBON; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CLORGYLINE; HOMOISOFLAVONOID; ISOFLAVONOID; LADOSTIGIL; MONOAMINE OXIDASE INHIBITOR; PARGYLINE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MEMBRANE PERMEABILITY;

GYMNOMYZA;

ALZHEIMER'S DISEASE; CHOLINESTERASE; MONOAMINE OXIDASE-B;

ALZHEIMER DISEASE; ANIMALS; BLOOD-BRAIN BARRIER; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; ELECTROPHORUS; HUMANS; ISOFLAVONES; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; SWINE; TACRINE;

EID: 84886947382     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.09.050     Document Type: Article

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