Design and synthesis of silicon-containing tubulin polymerization inhibitors: Replacement of the ethylene moiety of combretastatin A-4 with a silicon linker

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 23, 2013, Pages 7381-7391

  Nakamura, Masaharu ^a   Kajita, Daisuke ^a   Matsumoto, Yotaro ^a   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antitumor agent; Colchicine; Combretastatin; Silicon; Tubulin

Indexed keywords

(3 (BENZYLOXY) 4 METHOXYPHENYL)DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; (3 METHOXYPHENYL)DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; (3,4 DIMETHOXYPHENYL)DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; (4 (BENZYLOXY) 3 METHOXYPHENYL)DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; (4 METHOXYPHENYL)DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; 1 [3 (BENZYLOXY) 4 METHOXYPHENYL] 1 (3,4,5 TRIMETHOXYPHENYL)SILETANE; 2 METHOXY 5 [(7 METHOXYBENZO[D][1,3]DIOXOL 5 YL)DIMETHYLSILYL]PHENOL; 2 METHOXY 5 [1 (3,4,5 TRIMETHOXYPHENYL)SILETAN 1 YL]PHENOL; 3 [DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILYL]PHENOL; 4 [DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILYL]PHENOL; 5 [(3,4 DIMETHOXYPHENYL)DIMETHYLSILYL] 2 METHOXYPHENOL; 5 [DIETHYL(3,4,5 TRIMETHOXYPHENYL)SILYL] 2 METHOXYPHENOL; 5 [DIMETHYL (3,4,5-TRIMETHOXYPHENYL)SILYL] 2 METHOXYPHENOL; 5 [DIMETHYL(2,3,4 TRIMETHOXYPHENYL)SILYL] 2 METHOXYPHENOL; 5 [ETHOXY(PROPYL)(3,4,5 TRIMETHOXYPHENYL)SILYL] 2 METHOXYPHENOL; 5,5' (DIMETHYLSILANEDIYL)BIS(2 METHOXYPHENOL); [3 (BENZYLOXY) 4 METHOXYPHENYL]DIETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; [3 (BENZYLOXY)PHENYL]DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; [4 (BENZYLOXY)PHENYL]DIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; [4 METHOXY 3 (METHOXYMETHOXY)PHENYL](METHYL)(3,4,5 TRIMETHOXYPHENYL)SILANE; BENZO[D][1,3]DIOXOL 5 YLDIMETHYL(3,4,5 TRIMETHOXYPHENYL)SILANE; BIS[3 (BENZYLOXY) 4 METHOXYPHENYL]DIMETHYLSILANE; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A4; DIETHYLBIS(3,4,5 TRIMETHOXYPHENYL)SILANE; SILICON; SILICON CONTAINING TUBULIN POLYMERIZATION INHIBITOR; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PHYSICAL CHEMISTRY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTITUMOR AGENT; COLCHICINE; COMBRETASTATIN; SILICON; TUBULIN;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; COLCHICINE; DRUG DESIGN; FEMALE; HUMANS; SILICON; STILBENES; TUBULIN; TUBULIN MODULATORS;

EID: 84886947287     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.09.046     Document Type: Article

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