The local immunological microenvironment in colorectal cancer as a prognostic factor for treatment decisions in the clinic: The way ahead

OncoImmunology

Volumn 1, Issue 1, 2012, Pages 62-66

  Halama, Niels ^a   Zoernig, Inka ^a   Grabe, Niels ^a   Jaeger, Dirk ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Chemotherapy; Colorectal cancer; Immunomap; Lymphocytes; Prognosis; T cells; Whole slide imaging

Indexed keywords

ANTINEOPLASTIC AGENT;

CANCER CHEMOTHERAPY; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CANCER INVASION; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER SURGERY; CANCER THERAPY; CELL DIFFERENTIATION; CELL INFILTRATION; CELL INTERACTION; CLINICAL DECISION MAKING; COLORECTAL CANCER; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; PRIORITY JOURNAL; SHORT SURVEY; TUMOR MICROENVIRONMENT;

EID: 84886944846     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.1.1.18460     Document Type: Short Survey

References (30)

1. Pihl E, Nairn RC, Milne BJ, Cuthbertson AM, Hughes ES, Rollo A. Lymphoid hyperplasia: a major prognostic feature in 519 cases of colorectal carcinoma. Am J Pathol 1980; 100:469-80.
2. McDougall CJ, Ngoi SS, Goldman IS, Godwin T, Felix J, DeCosse JJ, et al. Reduced expression of HLA class I and II antigens in colon cancer. Cancer Res 1990; 50:8023-7.
3. Ohtani H, Naito Y, Saito K, Nagura H. Expression of costimulatory molecules B7-1 and B7-2 by macrophages along invasive margin of colon cancer: a possible antitumor immunity? Lab Invest 1997; 77:231-41.
4. Ohtani H. Pathophysiologic significance of host reactions in human cancer tissue: desmoplasia and tumor immunity. Tohoku J Exp Med 1999; 187:193-202 http://dx.doi.org/10.1620/tjem.187.193.
5. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 1997; 182:318-24 http://dx.doi.org/10.1002/(SICI)1096-9896(199707)182:3,318::AIDPATH862.3 .0.CO;2-6.
6. Nielsen HJ, Hansen U, Christensen IJ, Reimert CM, Brunner N, Moesgaard F. Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol 1999; 189:487-95 http://dx.doi.org/10.1002/(SICI)1096-9896(199912)189:4,487::AID-PATH484. 3.0.CO;2-I.
7. Menon AG, Janssen-van Rhijn CM, Morreau H, Putter H, Tollenaar RAEM, van de Velde CJH, et al. Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis. Lab Invest 2004; 84:493-501 http://dx.doi.org/10.1038/labinvest.3700055.
8. Prall F, Duhrkop T, Weirich V, Ostwald C, Lenz P, Nizze H, et al. Prognostic role of CD8+ tumorinfiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability. Hum Pathol 2004; 35:808-16 http://dx.doi.org/10.1016/j.humpath.2004.01.022.
9. Diederichsen ACP. Hjelmborg JvB, Christensen PB, Zeuthen J, Fenger C. Prognostic value of the CD4+/ CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells. Cancer Immunol Immunother 2003; 52:423-8 http://dx.doi.org/10.1007/s00262-003-0388-5.
10. Zitvogel L, Kepp O, Kroemer G. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol 2011; 8:151-60 http://dx.doi.org/10.1038/nrclinonc.2010.223.
11. Pagès F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010; 29:1093-102 http://dx.doi.org/10.1038/onc.2009.416.
12. Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 2005; 353:2654-66 http://dx.doi.org/10.1056/NEJMoa051424.
13. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006; 313: 1960-4 http://dx.doi.org/10.1126/science.1129139.
14. Pagès F, Kirilovsky A, Mlecnik B, Asslaber M, Tosolini M, Bindea G, et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol 2009; 27:5944-51 http://dx.doi.org/10.1200/JCO.2008.19.6147.
15. Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27:168-9.
16. Sinicrope FA, Rego RL, Ansell SM, Knutson KL, Foster NR, Sargent DJ. Intraepithelial effector (CD3+)/ regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009; 137:1270-9 http://dx.doi.org/10.1053/j.gastro.2009.06.053.
17. Fuchs TJ, Wild PJ, Moch H, Buhmann JM. Computational Pathology Analysis of Tissue Microarrays Predicts Survival of Renal Clear Cell Carcinoma Patients. Med Image Comput Comput Assist Interv 2008; 11:1-8.
18. Halama N, Zoernig I, Spille A, Westphal K, Schirmacher P, Jaeger D, et al. Estimation of Immune Cell Densities in Immune Cell Conglomerates: An Approach for High-Throughput Quantification. PLoS ONE 2009; 4:e7847 http://dx.doi.org/10.1371/journal.pone.0007847.
19. Halama N, Zoernig I, Spille A, Michel S, Kloor M, Grauling-Halama S, et al. Quantification of prognostic immune cell markers in colorectal cancer using whole slide imaging tumor maps. Anal Quant Cytol Histol 2010; 32:333-40.
20. Halama N, Michel S, Kloor M, Zoernig I, Pommerencke T, von Knebel Doeberitz M, et al. The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. Cancer Immun 2009; 9:1.
21. Katz SC, Pillarisetty V, Bamboat ZM, Shia J, Hedvat C, Gonen M, et al. T Cell Infiltrate Predicts Long-Term Survival Following Resection of Colorectal Cancer Liver Metastases. Ann Surg Oncol 2009; 16:2524-30 http://dx.doi.org/10.1245/s10434-009-0585-3.
22. Okano K, Maeba T, Moroguchi A, Ishimura K, Karasawa Y, Izuishi K, et al. Lymphocytic infiltration surrounding liver metastases from colorectal cancer. J Surg Oncol 2003; 82:28-33 http://dx.doi.org/10.1002/jso.10188.
23. Halama N, Michel S, Kloor M, Zoernig I, Benner A, Spille A, et al. Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy. Cancer Res 2011; 71:5670-7 http://dx.doi.org/10.1158/0008-5472.CAN-11-0268.
24. Morris M, Platell C, Iacopetta B. Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy. Clin Cancer Res 2008; 14:1413-7 http://dx.doi.org/10.1158/1078-0432.CCR-07-1994.
25. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3:991-8 http://dx.doi.org/10.1038/ni1102-991.
26. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 2006; 6:715-27 http://dx.doi.org/10.1038/nri1936.
27. Zitvogel L, Apetoh L, Ghiringhelli F, Andre F, Tesniere A, Kroemer G. The anticancer immune response: indispensable for therapeutic success? J Clin Invest 2008; 118:1991-2001 http://dx.doi.org/10.1172/JCI35180.
28. Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, et al. Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer. Gastroenterology 2010; 138:1429-40 http://dx.doi.org/10.1053/j.gastro.2009.10.057.
29. Bindea G, Mlecnik B, Fridman WH, Pages F, Galon J. Natural immunity to cancer in humans. Curr Opin Immunol 2010; 22:215-22 http://dx.doi.org/10.1016/j.coi.2010.02.006.
30. Halama N, Braun M, Kahlert C, Spille A, Quack C, Rahbari N, et al. Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines. Clin Cancer Res 2011; 17:678-89 http://dx.doi.org/10.1158/1078-0432.CCR-10-2173