T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases

Annals of Surgical Oncology

Volumn 16, Issue 9, 2009, Pages 2524-2530

  Katz, Steven C ^a   Pillarisetty, Venu ^a   Bamboat, Zubin M ^a   Shia, Jinru ^a   Hedvat, Cyrus ^a   Gonen, Mithat ^a   Jarnagin, William ^a   Fong, Yuman ^a   Blumgart, Leslie ^a   D'Angelica, Michael ^a   DeMatteo, Ronald P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; RISK ASSESSMENT; SURVIVAL TIME; TISSUE MICROARRAY; TREATMENT OUTCOME; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; AGED, 80 AND OVER; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE; TIME FACTORS;

EID: 68949204170     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0585-3     Document Type: Article

References (33)

1. MA Choti JV Sitzmann MF Tiburi et al 2002 Trends in long-term survival following liver resection for hepatic colorectal metastases Ann Surg 235 6 759 766
2. Y Fong J Fortner RL Sun et al 1999 Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases Ann Surg 230 3 309 318 discussion 318-21.
3. JS Tomlinson WR Jarnagin RP DeMatteo et al 2007 Actual 10-year survival after resection of colorectal liver metastases defines cure J Clin Oncol 25 29 4575 4580
4. A Falcone S Ricci I Brunetti et al 2007 Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest J Clin Oncol 25 13 1670 1676
5. H Hurwitz L Fehrenbacher W Novotny et al 2004 Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N Engl J Med 350 23 2335 2342
6. CG Clemente MC Mihm Jr R Bufalino et al 1996 Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma Cancer 77 7 1303 1310
7. J Fu D Xu Z Liu et al 2007 Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients Gastroenterology 132 7 2328 2339
8. J Galon A Costes F Sanchez-Cabo et al 2006 Type, density, and location of immune cells within human colorectal tumors predict clinical outcome Science 313 5795 1960 1964
9. F Pages A Berger M Camus et al 2005 Effector memory T cells, early metastasis, and survival in colorectal cancer N Engl J Med 353 25 2654 2666
10. L Zhang JR Conejo-Garcia D Katsaros et al 2003 Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer N Engl J Med 348 3 203 213
11. NN Hunder H Wallen J Cao et al 2008 Treatment of metastatic melanoma with autologous CD4 + T cells against NY-ESO-1 N Engl J Med 358 25 2698 2703
12. Wagner P, Koch M, Nummer D, et al. Detection and functional analysis of tumor infiltrating T-lymphocytes (TIL) in liver metastases from colorectal cancer. Ann Surg Oncol. 2008.
13. A Sasaki F Tanaka K Mimori et al 2008 Prognostic value of tumor-infiltrating FOXP3 + regulatory T cells in patients with hepatocellular carcinoma Eur J Surg Oncol 34 2 173 179
14. SC Katz VG Pillarisetty JI Bleier et al 2005 Conventional liver CD4 T cells are functionally distinct and suppressed by environmental factors Hepatology 42 2 293 300
15. SC Katz VG Pillarisetty JI Bleier et al 2004 Liver sinusoidal endothelial cells are insufficient to activate T cells J Immunol 173 1 230 235
16. TP Kingham UI Chaudhry G Plitas et al 2007 Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion Hepatology 45 2 445 454
17. VG Pillarisetty AB Shah G Miller et al 2004 Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition J Immunol 172 2 1009 1017
18. ZM Bamboat JA Stableford G Plitas et al 2009 Human liver dendritic cells promote T cell hyporesponsiveness J Immunol 182 4 1901 1911
19. A Goubier B Dubois H Gheit et al 2008 Plasmacytoid dendritic cells mediate oral tolerance Immunity 29 3 464 475
20. T Cohen D Prus J Shia et al 2008 Expression of P53, P27 and KI-67 in colorectal cancer patients of various ethnic origins: clinical and tissue microarray based analysis J Surg Oncol 97 5 416 422
21. A Hoos C Cordon-Cardo 2001 Tissue microarray profiling of cancer specimens and cell lines: opportunities and limitations Lab Invest 81 10 1331 1338
22. R Miller D Siegmund 1982 Maximaly selected chi square statistics Biometrics. 38 1011 1016
23. PA Antony CA Piccirillo A Akpinarli et al 2005 CD8 + T cell immunity against a tumor/self-antigen is augmented by CD4 + T helper cells and hindered by naturally occurring T regulatory cells J Immunol 174 5 2591 2601
24. N Hiraoka K Onozato T Kosuge et al 2006 Prevalence of FOXP3 + regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions Clin Cancer Res 12 18 5423 5434
25. J Galon WH Fridman F Pages 2007 The adaptive immunologic microenvironment in colorectal cancer: a novel perspective Cancer Res 67 5 1883 1886
26. B Ostenstad T Lea E Schlichting et al 1994 Human colorectal tumour infiltrating lymphocytes express activation markers and the CD45RO molecule, showing a primed population of lymphocytes in the tumour area Gut 35 3 382 387
27. C Yu HS Yu KH Sun et al 2002 Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase Clin Exp Immunol 129 1 78 85
28. E Takayama Y Koike T Ohkawa et al 2003 Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers, CD56 + CD57- T cells, CD56 + CD57 + T cells and CD56- CD57 + T cells Immunology 108 2 211 219
29. R Cubas M Li C Chen et al 2007 Colorectal cancer: new advances in immunotherapy Cancer Biol Ther 6 1 11 17
30. JB Vermorken AM Claessen H van Tinteren et al 1999 Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial Lancet 353 9150 345 350
31. N Rains RJ Cannan W Chen et al 2001 Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer Hepatogastroenterology 48 38 347 351
32. G Chong A Bhatnagar D Cunningham et al 2006 Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer Ann Oncol 17 3 437 442
33. MC Posner D Niedzwiecki AP Venook et al 2008 A phase II prospective multi-institutional trial of adjuvant active specific immunotherapy following curative resection of colorectal cancer hepatic metastases: cancer and leukemia group B study 89903 Ann Surg Oncol 15 1 158 164