Outcomes in newly diagnosed elderly glioblastoma patients after concomitant temozolomide administration and hypofractionated radiotherapy

Cancers

Volumn 5, Issue 3, 2013, Pages 1177-1198

  Nguyen, Ludovic T ^a   Touch, Socheat ^b,c   Nehme Schuster, Hélène ^b   Antoni, Delphine ^b   Eav, Sokha ^c   Clavier, Jean Baptiste ^b   Bauer, Nicolas ^b   Vigneron, Céline ^b   Schott, Roland ^b   Kehrli, Pierre ^a   Noël, Georges ^b,d  

^a HÔPITAL DE HAUTEPIERRE   (France)

^b Paul Strauss Centre   (France)

^c Radiation Oncology Department   (Cambodia)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Chemotherapy; Elderly; Hypofractionated radiotherapy

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CARMUSTINE; CILENGITIDE; ETOPOSIDE; IRINOTECAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE;

AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CHARLSON COMORBIDITY INDEX; CHEMORADIOTHERAPY; CLINICAL ARTICLE; DNA METHYLATION; FEMALE; GLIOBLASTOMA; HUMAN; HYPOFRACTIONATED RADIOTHERAPY; KARNOFSKY PERFORMANCE STATUS; MALE; MORTALITY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PATIENT COMPLIANCE; PROGRESSION FREE SURVIVAL; SKIN TOXICITY; THROMBOCYTOPENIA; TUMOR GROWTH;

EID: 84886940120     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers5031177     Document Type: Article

References (41)

1. Keime-Guibert, F.; Chinot, O.; Taillandier, L.; Cartalat-Carel, S.; Frenay, M.; Kantor, G.; Guillamo, J.S.; Jadaud, E.; Colin, P.; Bondiau, P.Y. et al. Radiotherapy for glioblastoma in the elderly. N. Engl. J. Med. 2007, 356, 1527-1535.
2. Roa, W.; Brasher, P.M.; Bauman, G.; Anthes, M.; Bruera, E.; Chan, A.; Fisher, B.; Fulton, D.; Gulavita, S.; Hao, C. et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial. J. Clin. Oncol. 2004, 22, 1583-1588.
3. Malmström, A.; Grønberg, B.H.; Marosi, C.; Stupp, R.; Frappaz, D.; Schultz, H.; Abacioglu, U.; Tavelin, B.; Lhermitte, B.; Hegi, M.E. et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The nordic randomised, phase 3 trial. Lancet Oncol. 2012, 13, 916-926.
4. Chinot, O.L.; Barrie, M.; Frauger, E. Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer 2004, 100, 2208-2214.
5. Laigle-Donadey, F.; Figarella-Branger, D.; Chinot, O.; Taillandier, L.; Cartalat-Carel, S.; Honnorat, J.; Kaloshi, G.; Delattre, J.Y.; Sanson, M. Up-front temozolomide in elderly patients with glioblastoma. J. Neurooncol. 2010, 99, 89-94.
6. Fiorica, F.; Berretta, M.; Colosimo, C.; Stefanelli, A.; Ursino, S.; Zanet, E.; Palmucci, T.; Maugeri, D.; Malaguarnera, M.; Palmucci, S. et al. Glioblastoma in elderly patients: Safety and efficacy of adjuvant radiotherapy with concomitant temozolomide. Arch. Gerontol. Geriatr. 2010, 51, 31-35.
7. Sijben, A.E.; McIntyre, J.B.; Roldan, G.B.; Easaw, J.C.; Yan, E.; Forsyth, P.A.; Parney, I.F.; Magliocco, A.M.; Bernsen, H.; Cairncross, J.G. Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J. Neurooncol. 2008, 89, 97-103.
8. Cao, J.Q.; Fisher, B.J.; Bauman, G.S.; Megyesi, J.F.; Watling, C.J.; Macdonald, D.R. Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: A review of ten-year single institutional experience. J. Neurooncol. 2012, 107, 395-405.
9. Chargari, C.; Feuvret, L.; Bauduceau, O.; Ricard, D.; Cuenca, X.; Delattre, J.Y.; Mazeron, J.J. Treatment of elderly patients with glioblastoma: From clinical evidence to molecular highlights. Cancer Treat. Rev. 2012, 38, 988-995.
10. Minniti, G.; Salvati, M.; Arcella, A.; Buttarelli, F.; D'Elia, A.; Lanzetta, G.; Esposito, V.; Scarpino, S.; Maurizi, E.R.; Giangaspero, F. Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide. J. Neurooncol. 2011, 102, 311-316.
11. Macdonald, D.R.; Cascino, T.L.; Schold, S.C., Jr.; Cairncross, J.G. Response criteria for phase ii studies of supratentorial malignant glioma. J. Clin. Oncol. 1990, 8, 1277-1280.
12. Scott, J.G.; Bauchet, L.; Fraum, T.J.; Nayak, L.; Cooper, A.R.; Chao, S.T.; Suh, J.H.; Vogelbaum, M.A.; Peereboom, D.M.; Zouaoui, S. et al. Recursive partitioning analysis of prognostic factors for glioblastoma patients aged 70 years or older. Cancer 2012, 118, 5595-5600.
13. Scott, J.G.; Suh, J.H.; Elson, P.; Barnett, G.H.; Vogelbaum, M.A.; Peereboom, D.M.; Stevens, G.H.; Elinzano, H.; Chao, S.T. Aggressive treatment is appropriate for glioblastoma multiforme patients 70 years old or older: A retrospective review of 206 cases. Neuro-oncology 2011, 13, 428-436.
14. Barker, C.A.; Chang, M.; Chou, J.F.; Zhang, Z.; Beal, K.; Gutin, P.H.; Iwamoto, F.M. Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma. J. Neurooncol. 2012, 109, 391-397.
15. Iwamoto, F.M.; Cooper, A.R.; Reiner, A.S.; Nayak, L.; Abrey, L.E. Glioblastoma in the elderly: The memorial sloan-kettering cancer center experience (1997-2007). Cancer 2009, 115, 3758-3766.
16. Bauchet, L.; Mathieu-Daude, H.; Fabbro-Peray, P.; Rigau, V.; Fabbro, M.; Chinot, O.; Pallusseau, L.; Carnin, C.; Laine, K.; Schlama, A. et al. Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004. Neuro-oncology 2010, 12, 725-735.
17. Shikama, N.; Sasaki, S.; Shinoda, A.; Koiwai, K. Treatment outcome of elderly patients with glioblastoma who received combination therapy. Am. J. Clin. Oncol. 2012, 35, 486-489.
18. Brandes, A.A.; Vastola, F.; Basso, U.; Berti, F.; Pinna, G.; Rotilio, A.; Gardiman, M.; Scienza, R.; Monfardini, S.; Ermani, M. A prospective study on glioblastoma in the elderly. Cancer 2003, 97, 657-662.
19. Combs, S.E.; Wagner, J.; Bischof, M.; Welzel, T.; Edler, L.; Rausch, R.; Wagner, F.; Zabel-du, B.A.; Debus, J.; Schulz-Ertner, D. Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens. Int. J. Radiat. Oncol. Biol. Phys. 2008, 71, 999-1005.
20. Combs, S.E.; Wagner, J.; Bischof, M.; Welzel, T.; Wagner, F.; Debus, J.; Schulz-Ertner, D. Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int. J. Radiat. Oncol. Biol. Phys. 2008, 70, 987-992.
21. Minniti, G.; Lanzetta, G.; Scaringi, C.; Caporello, P.; Salvati, M.; Arcella, A.; de Sanctis, V.; Giangaspero, F.; Enrici, R.M. Phase ii study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 2012, 83, 93-99.
22. Reyngold, M.; Lassman, A.B.; Chan, T.A.; Yamada, Y.; Gutin, P.H.; Beal, K. Abbreviated course of radiation therapy with concurrent temozolomide for high-grade glioma in patients of advanced age or poor functional status. J. Neurooncol. 2012, 110, 369-374.
23. Holdhoff, H.; Rosner, G.I.; Alcorn, S.; Grossman, S.A. "Elderly" patients with newly diagnosed glioblastoma deserve optimal care. J. Neurooncol. 2013, 113, 343-344.
24. Stupp, R.; Mason, W.P.; van den Bent, M.J.; Weller, M.; Fisher, B.; Taphoorn, M.J.; Belanger, K.; Brandes, A.A.; Marosi, C.; Bogdahn, U. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 2005, 352, 987-996.
25. Wick, W.; Platten, M.; Meisner, C.; Felsberg, J.; Tabatabai, G.; Simon, M.; Nikkhah, G.; Papsdorf, K.; Steinbach, J.P.; Sabel, M. et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The noa-08 randomised, phase 3 trial. Lancet Oncol. 2012, 13, 707-715.
26. Chamberlain, M.C.; Chalmers, L. A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma. J. Neurooncol. 2007, 82, 207-209.
27. Gerstner, E.R.; Yip, S.; Wang, D.L.; Louis, D.N.; Iafrate, A.J.; Batchelor, T.T. Mgmt methylation is a prognostic biomarker in elderly patients with newly diagnosed glioblastoma. Neurology 2009, 73, 1509-1510.
28. Fiorentino, A.; Caivano, R.; Chiumento, C.; Cozzolino, M.; Clemente, S.; Pedicini, P.; Fusco, V. Comorbidity assessment and adjuvant radiochemotherapy in elderly affected by glioblastoma. Med. Oncol. 2012, 29, 3467-3471.
29. Gallego, P.J.; Ducray, F.; Chinot, O.; Catry-Thomas, I.; Taillandier, L.; Guillamo, J.S.; Campello, C.; Monjour, A.; Cartalat-Carel, S.; Barrie, M. et al. Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: An anocef phase II trial. J. Clin. Oncol. 2011, 29, 3050-3055.
30. Glantz, M.; Chamberlain, M.; Liu, Q.; Litofsky, N.S.; Recht, L.D. Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 2003, 97, 2262-2266.
31. McAleese, J.J.; Stenning, S.P.; Ashley, S.; Traish, D.; Hines, F.; Sardell, S.; Guerrero, D.; Brada, M. Hypofractionated radiotherapy for poor prognosis malignant glioma: Matched pair survival analysis with mrc controls. Radiother. Oncol. 2003, 67, 177-182.
32. Bauman, G.S.; Gaspar, L.E.; Fisher, B.J.; Halperin, E.C.; Macdonald, D.R.; Cairncross, J.G. A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme. Int. J. Radiat. Oncol. Biol. Phys. 1994, 29, 835-839.
33. Villa, S.; Vinolas, N.; Verger, E.; Yaya, R.; Martinez, A.; Gil, M.; Moreno, V.; Caral, L.; Graus, F. Efficacy of radiotherapy for malignant gliomas in elderly patients. Int. J. Radiat. Oncol. Biol. Phys. 1998, 42, 977-980.
34. Mohan, D.S.; Suh, J.H.; Phan, J.L.; Kupelian, P.A.; Cohen, B.H.; Barnett, G.H. Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution. Int. J. Radiat. Oncol. Biol. Phys. 1998, 42, 981-987.
35. Patwardhan, R.V.; Shorter, C.; Willis, B.K.; Reddy, P.; Smith, D.; Caldito, G.C.; Nanda, A. Survival trends in elderly patients with glioblastoma multiforme: Resective surgery, radiation, and chemotherapy. Surg. Neurol. 2004, 62, 207-215.
36. Pierga, J.Y.; Hoang-Xuan, K.; Feuvret, L.; Simon, J.M.; Cornu, P.; Baillet, F.; Mazeron, J.J.; Delattre, J.Y. Treatment of malignant gliomas in the elderly. J. Neurooncol. 1999, 43, 187-193.
37. Hoegler, D.B.; Davey, P. A prospective study of short course radiotherapy in elderly patients with malignant glioma. J. Neurooncol. 1997, 33, 201-204.
38. Blumenthal, D.T.; Won, M.; Mehta, M.P.; Curran, W.J.; Souhami, L.; Michalski, J.M.; Rogers, C.L.; Corn, B.W. Short delay in initiation of radiotherapy may not affect outcome of patients with glioblastoma: A secondary analysis from the radiation therapy oncology group database. J. Clin. Oncol. 2009, 27, 733-739.
39. Do, V.; Gebski, V.; Barton, M.B. The effect of waiting for radiotherapy for grade III/IV gliomas. Radiother. Oncol. 2000, 57, 131-136.
40. Noel, G.; Huchet, A.; Feuvret, L.; Maire, J.P.; Verrelle, P.; Le Rhun, E.; Aumont, M.; Thillays, F.; Sunyach, M.P.; Henzen, C. et al. Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: A french retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy. J. Neurooncol. 2012, 109, 167-175.
41. Balducci, M.; Fiorentino, A.; de Bonis, P.; Chiesa, S.; Manfrida, S.; D'Agostino, G.R.; Mantini, G.; Frascino, V.; Mattiucci, G.C.; de Bari, B. et al. Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: A pooled data analysis of three prospective mono-institutional phase ii studies. Med. Oncol. 2012, 29, 3478-3483.