Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide

Journal of Neuro-Oncology

Volumn 102, Issue 2, 2011, Pages 311-316

  Minniti, Giuseppe ^a,b   Salvati, M ^b   Arcella, A ^b   Buttarelli, F ^c   D'Elia, A ^c   Lanzetta, G ^b   Esposito, V ^b   Scarpino, S ^a   Maurizi Enrici, R ^a   Giangaspero, F ^b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Elderly; Glioblastoma; MGMT; Radiotherapy; Temozolomide

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; ALKYLATING AGENT; DACARBAZINE; DNA; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; MGMT PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN;

AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DNA METHYLATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FATIGUE; FEMALE; GLIOBLASTOMA; HUMAN; LEUKOENCEPHALOPATHY; LUNG EMBOLISM; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUROTOXICITY; NEUTROPENIA; OVERALL SURVIVAL; PNEUMONIA; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROMOTER REGION; RADIATION DOSE; THROMBOCYTOPENIA; BRAIN TUMOR; EPIGENETICS; GENETICS; MORTALITY; MULTIMODALITY CANCER THERAPY; POLYMERASE CHAIN REACTION; SURVIVAL RATE; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; DACARBAZINE; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; DNA, NEOPLASM; EPIGENOMICS; FEMALE; GLIOBLASTOMA; HUMANS; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RADIOTHERAPY DOSAGE; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEINS;

EID: 79953722816     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0324-4     Document Type: Article

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