Phase II Study of Temozolomide without Radiotherapy in Newly Diagnosed Glioblastoma Multiforme in an Elderly Populations

Cancer

Volumn 100, Issue 10, 2004, Pages 2208-2214

  Chinot, Olivier L ^a,b   Barrle, Maryline ^a,b   Frauger, Elisabeth ^a   Dufour, Henry ^a   Figarella Branger, Dominique ^a   Palmari, Jacky ^b   Braguer, D ^a   Hoang Xuan, Khe ^c   Moktari, Karima ^c   Peragut, Jean Claude C ^a   Martin, Pierre Marie M ^b   Grisoli, François ^a  

^a TIMONE HOSPITAL   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Elderly; First line chemotherapy; Glioblastoma multiforme; Temozolomide

Indexed keywords

TEMOZOLOMIDE;

AGED; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; ELDERLY CARE; FATIGUE; FEMALE; GLIOBLASTOMA; HUMAN; MALE; NAUSEA; NEUROTOXICITY; NEUTROPENIA; OPEN STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; SIDE EFFECT; THROMBOCYTOPENIA; VOMITING;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; DACARBAZINE; FEMALE; GLIOBLASTOMA; HUMANS; MALE; PROGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 1042297227     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.20224     Document Type: Article

References (23)

1. Werner MH, Phuphanich S, Lyman GH. The increasing incidence of malignant gliomas and primary central nervous system lymphoma in the elderly. Cancer. 1995;76:1634-1642.
2. Fleury A, Menegoz F, Grosclaude P, et al. Descriptive epidemiology of cerebral gliomas in France. Cancer. 1997;79:1195-1202.
3. Fernandez PM, Brem S. Malignant brain tumors in the elderly. Clin Geriatr Med. 1997;13:327-338.
4. Zampieri P, Faggin R, Rigon A, et al. Malignant cerebral gliomas in the elderly [abstract]. J Neurooncol. 1996;155.
5. Meckling S, Dold O, Forsyth PA, Brasher P, Hagen NA. Malignant supratentorial glioma in the elderly: is radiotherapy useful? Neurology. 1996;47:901-905.
6. Mohan DS, Suh JH, Phan J, Kupelian PA, Cohen BH, Barnett GH. Results of definitive surgery and radiation therapy for patients aged > 70 years with supratentorial glioblastoma multiforme: the Cleveland Clinic experience [abstract]. Neurology. 1998;50:A353.
7. Grant R, Liang BC, Page MA, Crane DL, Greenberg HS, Junck L. Age influences chemotherapy response in astrocytomas. Neurology. 1995;45:929-933.
8. Keny PJ, Hunt C. The limited value of cytoreductive surgery in elderly patients with malignant gliomas. Neurosurgery. 1994;34:62-66.
9. Villa S, Vinolas N, Verger E, et al. Efficacy of radiotherapy for malignant gliomas in elderly patients. Int J Radiat Oncol Biol Phys. 1998;42:977-980.
10. Yung WK, Prados MD, Yaya-Tur R, et al. Multicenter Phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. J Clin Oncol. 1999;17:2762-2771.
11. Yung WK, Albright RE, Olson J, et al. A Phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer. 2000;83:588-593.
12. Gilbert MR, Friedman HS, Kuttesch JF, et al. A Phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy. Neurooncol. 2002;4:261-267.
13. Macdonald DR, Cascino TL, Schold SC, Cairncross JG. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol. 1990;8:1277-1280.
14. Whittle IR, Basu N, Grant R, Walker M, Gregor A. Management of patients aged > 60 years with malignant glioma: good clinical status and radiotherapy determine outcome. Br J Neurosurg. 2002;16:343-347.
15. Vigliani MC, Delattre JY. Radiation-induced cognitive dysfunction in adults: a review. Handbook Clin Neurol. 1997;23:371-388.
16. Chang EL, Yi W, Allen PK, Levin VA, Sawaya RE, Maor MH. Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys. 2003;56:519-528.
17. Pierga JY, Hoang-Xuan K, Feuvret L, et al. Treatment of malignant gliomas in the elderly. J Neurooncol. 1999;43:187-193.
18. Gilbert MR, Bozik M, Armstrong TS, et al. Aggressive chemotherapy treatment of brain tumors in the elderly: results from a Phase II study [abstract]. Proc Am Soc Clin Oncol. 1996;15:152.
19. Gilbert M, O'Neill A, Grossman S, et al. A Phase II study of preradiation chemotherapy followed by external beam radiotherapy for the treatment of patients with newly diagnosed glioblastoma multiforme: an Eastern Cooperative Oncology Group study (E2393). J Neurooncol. 2000;47:145-152.
20. Brandes AA, Vastola F, Basso U, et al. A prospective study on glioblastoma in the elderly. Cancer. 2003;97:657-662.
21. Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD. Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer. 2003;97:2262-2266.
22. Harris MT, Rosenthal MA, Ashley DL, Cher L. An Australian experience with temozolomide for the treatment of recurrent high grade gliomas. J Clin Neurosci. 2001;8:325-357.
23. Caimcross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst. 1998;90:1473-1479.