Binding of bovine T194A PrPC by PrPSc-specific antibodies: Potential implications for immunotherapy of familial prion diseases

Prion

Volumn 7, Issue 4, 2013, Pages 301-311

  Madampage, Claudia A ^a,b   Maattanen, Pekka ^a   Marciniuk, Kristen ^a,b   Brownlie, Robert ^a   Andrievskaia, Olga ^d   Potter, Andrew ^a   Cashman, Neil ^c   Lee, Jeremy S ^b   Napper, Scott ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d CANADIAN FOOD INSPECTION AGENCY   (Canada)

Author keywords

Antibodies; Conformation specific immunotherapy; Nanopore; Neurodegenerative diseases; Prion diseases; Protein conformation; Protein denaturation; Protein misfolding

Indexed keywords

POLYCLONAL ANTIBODY; PRION PROTEIN; RECOMBINANT PROTEIN;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IMMUNOTHERAPY; IN VITRO STUDY; NANOPORE; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN FOLDING;

ANTIBODIES; CONFORMATION-SPECIFIC IMMUNOTHERAPY; NANOPORE; NEURODEGENERATIVE DISEASES; PRION DISEASES; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MISFOLDING;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CATTLE; DEMENTIA; HEK293 CELLS; HUMANS; IMMUNOTHERAPY; MUTATION, MISSENSE; PROTEIN FOLDING; PRPC PROTEINS; PRPSC PROTEINS; VACCINES;

EID: 84886939677     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.25148     Document Type: Article

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