Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3222-3228

  Tavassoly, Omid ^a   Lee, Jeremy S ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Synuclein; Induced folding; Intrinsically disordered protein; Nanopore analysis; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; METHAMPHETAMINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DISEASE ASSOCIATION; DRUG PROTEIN BINDING; INCIDENCE; METHAMPHETAMINE DEPENDENCE; NANOPORE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ALPHA-SYNUCLEIN; BINDING SITES; CIRCULAR DICHROISM; DOPAMINERGIC NEURONS; HUMANS; LEWY BODIES; LEWY BODY DISEASE; METHAMPHETAMINE; MODELS, MOLECULAR; NANOPORES; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 84866620299     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.06.040     Document Type: Article

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