The human adenovirus 5 l4 promoter is activated by cellular stress response protein p53

Journal of Virology

Volumn 87, Issue 21, 2013, Pages 11616-11625

  Wright, Jordan ^a   Leppard, Keith N ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; PROTEIN P53; PROTEIN BINDING;

ADENOVIRUS INFECTION; ARTICLE; CELLULAR STRESS RESPONSE; CHROMATIN IMMUNOPRECIPITATION; DNA REPLICATION; FEEDBACK SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN ADENOVIRUS 5; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN PROCESSING; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN ADENOVIRUS; METABOLISM; TRANSCRIPTION INITIATION;

ADENOVIRUSES, HUMAN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION, VIRAL; HOST-PATHOGEN INTERACTIONS; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84886888907     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01924-13     Document Type: Article

References (44)

1. Russell WC. 2000. Update on adenovirus and its vectors. J. Gen. Virol. 81:2573-2604
2. Huang W, Kiefer J, Whalen D, Flint SJ. 2003. DNA synthesis-dependent relief of repression of transcription from the adenovirus type 2 IVa2 promoter by a cellular protein. Virology 314:394-402
3. Iftode C, Flint SJ. 2004. Viral DNA synthesis-dependent titration of a cellular repressor activates transcription of the human adenovirus type 2 IVa2 gene. Proc. Natl. Acad. Sci. U. S. A. 101:17831-17836
4. Binger MH, Flint SJ. 1984. Accumulation of early and intermediate mRNA species during subgroup C adenovirus productive infections. Virology 136:387-403
5. Nevins JR, Wilson MC. 1981. Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing. Nature 290:113-118
6. Shaw AR, ZiffEB. 1980. Transcripts from the adenovirus-2 major late promoter yield a single early family of 32 coterminal mRNAs and five late families. Cell 22:905-916
7. Ostapchuk P, Anderson ME, Chandrasekhar S, Hearing P. 2006. The L4 22-kilodalton protein plays a role in packaging of the adenovirus genome. J. Virol. 80:6973-6981
8. Ali H, LeRoy G, Bridge G, Flint SJ. 2007. The adenovirus L4 33-kilodalton protein binds to intragenic sequences of the major late promoter required for late phase-specific stimulation of transcription. J. Virol. 81:1327-1338
9. Backström E, Kaufmann KB, Lan X, Akusjärvi G. 2010. Adenovirus L4-22K stimulates major late transcription by a mechanism requiring the intragenic late-specific transcription factor-binding site. Virus Res. 151: 220-228
10. Tormanen H, Backstrom E, Carlsson A, Akusjarvi G. 2006. L4-33K, an adenovirus-encoded alternative RNA splicing factor. J. Biol. Chem. 281: 36510-36517
11. Farley DC, Brown JL, Leppard KN. 2004. Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products. J. Virol. 78:1782-1791
12. Morris SJ, Leppard KN. 2009. Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression. J. Virol. 83:3049-3058
13. Guimet D, Hearing P. 2013. The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome. J. Virol. 87:7688-7699
14. Wu K, Orozco D, Hearing P. 2012. The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection. J. Virol. 86:10474-10483
15. Wu K, Guimet D, Hearing P. 2013. The adenovirus L4-33K protein regulates both late gene expression patterns and viral DNA packaging. J. Virol. 87:6739-6747
16. Morris SJ, Scott GE, Leppard KN. 2010. Adenovirus late phase infection is controlled by a novel L4 promoter. J. Virol. 84:7096-7104
17. Vousden KH, Lane DP. 2007. p53 in health and disease. Nat. Rev. Mol. Cell Biol. 8:275-283
18. Braithwaite A, Nelson C, Skulimowski A, McGovern J, Pigott D, Jenkins J. 1990. Transactivation of the p53 oncogene by E1a gene products. Virology 177:595-605
19. Lowe SW, Ruley HE. 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:535-545
20. Sarnow P, Ho YS, Williams J, Levine AJ. 1982. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28:387-394
21. Zantema A, Fransen JAM, Davis-Olivier A, Ramaekers FCS, Vooijs GP, Deleys B, Van Der Eb AJ. 1985. Localization of the E1 B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. Virology 142:44-58
22. Yew PR, Berk AJ. 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82-85
23. Miller DL, Rickards B, Mashiba M, Huang W, Flint SJ. 2009. The adenoviral E1b 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription. J. Virol. 83:3591-3603
24. Hobom U, Dobbelstein M. 2004. E1b-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection. J. Virol. 78:7685-7697
25. Soria C, Estermann FE, Espantman KC, O'Shea CC. 2010. Heterochromatin silencing of p53 target genes by a small viral protein. Nature 466: 1076-1081
26. Dallaire F, Blanchette P, Branton PE. 2009. A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1b55K and other viral cullin-based E3 ubiquitin ligases. J. Virol. 83:12172-12184
27. Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE. 2001. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a cullin-containing complex. Genes Dev. 15:3104-3117
28. Schreiner S, Wimmer P, Groitl P, Chen S-Y, Blanchette P, Branton PE, Dobner T. 2011. Adenovirus type 5 early region 1b 55K oncoproteindependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. J. Virol. 85:8752-8765
29. Hall AR, Dix BR, O'Carroll SJ, Braithwaite AW. 1998. p53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nat. Med. 4:1068-1072
30. Royds JA, Hibma M, Dix BR, Hananeia L, Russell IA, Wiles A, Wynford-Thomas D, Braithwaite AW. 2006. p53 promotes adenoviral replication and increases late viral gene expression. Oncogene 25:1509-1520
31. Dix BR, O'Carroll SJ, Myers CJ, Edwards SJ, Braithwaite AW. 2000. Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53. Cancer Res. 60:2666-2672
32. Chahal JS, Flint SJ. 2013. The p53 protein does not facilitate adenovirus type 5 replication in normal human cells. J. Virol. 87:6044-6046
33. König C, Roth J, Dobbelstein M. 1999. Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein. J. Virol. 73:2253-2262
34. Jones N, Shenk T. 1978. Isolation of deletion and substitution mutants of adenovirus type 5. Cell 13:181-188
35. Chartier C, Degryse E, Gantzer M, Dieterle A, Pavirani A, Mehtali M. 1996. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol. 70:4805-4810
36. Brey S. 1999. Construction of IVa2-deficient adenovirus using complementing cell lines. PhD Thesis, University of Warwick, Coventry, United Kingdom
37. Hoppe A, Beech SJ, Dimmock J, Leppard KN. 2006. Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption. J. Virol. 80:3042-3049
38. Rodriguez MS, Desterro JMP, Lain S, Midgley CA, Lane DP, Hay RT. 1999. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 18:6455-6461
39. Harlow E, Franza BR, Schley C. 1985. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55:533-546
40. Wood DJ, Minor PD. 1990. Use of human diploid cells in vaccine production. Biologicals 18:143-146
41. Lethbridge KJ, Scott GE, Leppard KN. 2003. Nuclear matrix localization and SUMO-1 modification of adenovirus type 5 E1b 55K protein are controlled by E4 Orf6 protein. J. Gen. Virol. 84:259-268
42. Ewing SG, Byrd SA, Christensen JB, Tyler RE, Imperiale MJ. 2007. Ternary complex formation on the adenovirus packaging sequence by the IVa2 and L4 22-kilodalton proteins. J. Virol. 81:12450-12457
43. Harada JN, Berk AJ. 1999. p53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol. 73:5333-5344
44. Grand RJA, Grant ML, Gallimore PH. 1994. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology 203:229-240.