Circulating ghrelin was negatively correlated with pulmonary arterial pressure in atrial septal defect patients

Chinese Medical Journal

Volumn 126, Issue 20, 2013, Pages 3936-3939

  Li, Zhao Feng ^a,b   Zhou, Da Xin ^a   Pan, Wen Zhi ^a   Zhang, Lei ^a   Ge, Jun Bo ^a  

^a FUDAN UNIVERSITY   (China)

^b No 88 Hospital of People's Liberation Army   (China)

Author keywords

Atrial septal defect; Ghrelin; Obestatin; Pulmonary arterial hypertension

Indexed keywords

GHRELIN; INSULIN; OBESTATIN;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART ATRIUM SEPTUM DEFECT; HEART CATHETERIZATION; HEART EJECTION FRACTION; HEART LEFT VENTRICLE CONTRACTILITY; HUMAN; INSULIN RESISTANCE; LUNG ARTERY PRESSURE; M MODE ECHOCARDIOGRAPHY; PULMONARY HYPERTENSION; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ADOLESCENT; ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASTING; FEMALE; GHRELIN; HEART SEPTAL DEFECTS, ATRIAL; HUMANS; HYPERTENSION, PULMONARY; INSULIN; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84886885385     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20123353     Document Type: Article

References (17)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptides from stomach. Nature 1999; 402: 656-660.
2. Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008; 29: 1255-1270.
3. Kishimoto I, Tokudome T, Hosoda H, Miyazato M, Kangawa K. Ghrelin and cardiovascular diseases. J Cardiol 2012; 59: 8-13.
4. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, et al. Hemodynamic and hormonal effects of human ghrelin in healthy voluntees. Am J Physiol Regul Integr Comp Physiol 2001; 280: R1483-R1487.
5. Matsumura K, Tsuchihashi T, Fujii K, Abe I, Iida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 2002; 40: 694-699.
6. Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, et al. Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology 2008; 149: 237-244.
7. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-999.
8. Anderwald-Stadler M, Krebs M, Promintzer M, Mandl M, Bischof MG, Nowotny P, et al. Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans. Am J Physiol Endocrinol Metab 2007; 293: E1393-E1398.
9. Li ZF, Guo ZF, Cao J, Hu JQ, Zhao XX, Xu RL, et al. Plasma ghrelin and obestatin levels are increased in spontaneously hypertensive rats. Peptides 2010; 31: 297-300.
10. Li ZF, Guo ZF, Yang SG, Zheng X, Cao J, Qin YW. Circulating ghrelin and ghrelin to obestatin ratio are low in patients with untreated mild-to-moderate hypertension. Regul Pept 2010; 165: 206-209.
11. Diller GP, Baumgartner H. Pulmonary arterial hypertension in adults with congenital heart disease. Int J Clin Pract Suppl 2010; 165: 13-24
12. Zamanian RT, Hansmann G, Snook S, Lilienfeld D, Rappaport KM, Reaven GM, et al. Insulin resistance in pulmonary arterial hypertension. Eur Respir J 2009; 33: 318-324.
13. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol 2009; 53: 1573-1619.
14. Masure J, Gavora P, Formanek A, Hijazi ZM. Transcatheter closure of secundum atrial septal defects using the new selfcentering amplatzer septal occluder: initial human experience. Catheter Cardiovasc Diagn 1997; 42: 388-393.
15. Chen C, Lu FC. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci 2004; 17: 1-36.
16. Cheitlin MD, Armstrong WF, Aurigemma GP, Beller GA, Bierman FZ, Davis JL, et al. ACC/AHA/ ASE 2003 guideline update for the clinical application of echocardiography-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). J Am Coll Cardiol 2003; 42: 954-970.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.