Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 12, 2013, Pages 3921-3928

  Hsu, Ya Ching ^a   Chen, Bud Gen ^a   Yang, Shu Ching ^b   Wang, Yu Shan ^c   Huang, Shiao Ping ^a   Huang, Mei Han ^a   Chen, Tai Jui ^d   Liu, Hsu Chun ^c   Lin, Dong Liang ^c   Liu, Ray H ^a   Jones, A Wayne ^e  

^a FOOYIN UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c Institute of Forensic Medicine   (Taiwan)

^d E DA HOSPITAL   (Taiwan)

^e DEPARTMENT OF FORENSIC GENETICS AND FORENSIC TOXICOLOGY   (Sweden)

Author keywords

Blood; EDDP; GC MS; Methadone; Oral fluid; Plasma

Indexed keywords

CELLS; DETOXIFICATION; FORENSIC SCIENCE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMAS;

EDDP; GAS CHROMATOGRAPHY-MASS SPECTROMETRIES (GC-MS); GC-MS; LABELED INTERNAL STANDARDS; LIMITS OF QUANTITATIONS; METHADONE; ORAL FLUIDS; PHOSPHATE-BUFFERED SALINES;

BLOOD;

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE; METHADONE; NARCOTIC ANALGESIC AGENT; PYRROLIDINE DERIVATIVE;

ARTICLE; BLOOD; CHEMISTRY; EVALUATION; HUMAN; LIMIT OF DETECTION; MASS FRAGMENTOGRAPHY; METHODOLOGY; SALIVA;

ANALGESICS, OPIOID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIMIT OF DETECTION; METHADONE; PYRROLIDINES; SALIVA;

EID: 84886843376     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6460-2     Document Type: Article

References (42)

1. Kreek MJ, Vocci FJ (2002) History and current status of opioid maintenance treatments: blending conference session. J Subst Abuse Treat 23:93-105
2. Dole VP, Nyswander M (1965) A medical treatment for diacetylmorphine (heroin) addiction-a clinical trial with methadone hydrochloride. JAMA 193:646-650
3. Drummer OH, Opeskin K, Syrjanen M, Cordner SM (1992) Methadone toxicity causing death in ten subjects starting on a methadone maintenance program. Am J Forensic Med Pathol 13:346-350
4. Milroy CM, Forrest AR (2000) Methadone deaths: a toxicological analysis. J Clin Pathol 53:277-281
5. Seymour A, Black M, Jay J, Cooper G, Weir C, Oliver J (2003) The role of methadone in drug-related deaths in the west of Scotland. Addiction 98:995-1002
6. Shields LB, Hunsaker JC III, Corey TS, Ward MK, Stewart D (2007) Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area. J Forensic Sci 52:1389-1395
7. Laberke PJ, Bartsch C (2010) Trends in methadone-related deaths in Zurich. Int J Legal Med 124:381-385
8. Okie S (2010) A flood of opioids, a rising tide of deaths. N Engl J Med 363:1981-1985
9. Albion C, Shkrum M, Cairns J (2010) Contributing factors to methadone-related deaths in Ontario. Am J Forensic Med Pathol 31:313-319
10. Madden ME, Shapiro SL (2011) The methadone epidemic: methadone-related deaths on the rise in Vermont. Am J Forensic Med Pathol 32:131-135
11. Jones AW, Larsson H (2004) Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit. Ther Drug Monit 26:380-385
12. Rowland M, Tozer TN (1995) Clinical pharmacokinetics-concepts and applications. Williams & Wilkins, Baltimore
13. Toennes SW, Steinmeyer S, Maurer H-J, Moeller MR, Hauert GF (2005) Screening for drugs of abuse in oral fluid-correlation of analysis results with serum in forensic cases. J Anal Toxicol 29:22-27
14. Vindenes V, Lund HME, Andresen W, Gjerde H, Ikdahl SE, Christophersen AS, Ølestad EL (2012) Detection of drugs of abuse in simultaneously collected oral fluid and blood from Norwegian drug drivers. Forensic Sci Int 219:165-171
15. Wiese Simonsen K, Steentoft A, Hels T, Bernhoft IM, Rasmussen BS, Linnet K (2012) Presence of psychoactive substances in oral fluid from randomly selected drivers in Denmark. Forensic Sci Int 221:33-38
16. Yang S-C, Huang S-P, Yang M-Y, Liu RH, Wang S-J, Wu H-C, Huang Y-J, Li J-H (2011) Can pharmacogenetic studies improve the effectiveness of methadone maintenance programs? 2011 Annual Meeting of American Academy of Forensic Sciences; Chicago, IL, US
17. Liu RH, Wang S-M, Canfield DV (2010) Quantitation and mass spectrometric data of drugs and isotopically labeled analogs. CRC Press, Boca Raton
18. Crouch DJ (2005) Oral fluid collection: the neglected variable in oral fluid testing. Forensic Sci Int 150:165-173
19. Wang CT, Lin H-C, Liao LF, Liu RH (2011) Taiwan Patent No. M412772
20. Baugh LD, Liu RH, Walia AS (1991) Simultaneous gas chromatography/mass spectrometry assay of methadone and 2-ethyl-1,5-dimethyl-3,3-diphenyl- pyrrolidine (EDDP) in urine. J Forensic Sci 36:548-555
21. Bosker WM, Huestis MA (2009) Oral fluid testing for drugs of abuse. Clin Chem 55:1910-1931
22. Gallardo E, Barroso M, Queiroz JA (2009) Current technologies and considerations for drug bioanalysis in oral fluids. Bioanalysis 1:637-667
23. Jones AW, Holmgren A, Kugelberg FC (2007) Concentrations of scheduled prescription drugs in blood of impaired drivers. Considerations for interpreting the results. Ther Drug Monit 29:248-260
24. Levine B (ed) (2006) Principles of forensic toxicology, 2nd edn. CRC Press, Boca Raton
25. Drummer OH (2006) Drug testing in oral fluid. Clin Biochem Rev 27:147-159
26. Schwilke EW, Karschner EL, Lowe RH, Gordon AM et al (2009) Intra-and inter-subject whole blood/plasma cannabinoid ratios determined by 2-dimensional electron impact GC-MS with cryofocusing. Clin Chem 55:1188-1195
27. Iffland R, West A, Bilzer N, Schuff A (1999) Zur Zuverlässigkeit der Blutalkohol-bestimmung. Das verkeilungsverhältnis des Wassers zwischen Serum und Vollblut. Rechtsmedizin 9:123-130
28. Charlebois RC, Corbett MR, Wigmore JG (1996) Comparison of ethanol concentrations in blood, serum, and blood cells for forensic applications. J Anal Toxicol 20:171-178
29. Hinderling PH (1997) Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics. Pharmacol Rev 49:279-295
30. Inturrisi CE, Colburn WA, Kaiko RF, Houde RW, Foley KM (1987) Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther 41:392-401
31. Brunton LL, Lazo JS, Parker KL (eds) (2006) Goodman & Gilman's the pharmacological basis of therapeutics, 11th edn. McGraw-Hill, New York
32. Malarkey LM, McMorrow ME (eds) (2000) Nurse's manual of laboratory test and diagnostic procedure, 2nd edn. W.B. Saunder Co., Philadelphia
33. Rowland M, Emmons GT (2010) Use of dried blood spots in drug development: pharmacokinetic considerations. AAPS J 12:290-293
34. Aps JKM, Martens LC (2005) The physiology of saliva and transfer of drugs into saliva. Forensic Sci Int 150:119-131
35. Kintz P, Samyn N (2002) Use of alternative specimens: drugs of abuse in saliva and doping agents in hair. Ther Drug Monit 24:239-246
36. Schramm W, Smith RH, Craig PA, Kidwell DA (1992) Drugs of abuse in saliva: a review. J Anal Toxicol 16:1-9
37. Bermejo AM, Lucas ACS, Tabernero MJ (2000) Saliva/plasma ratio of methadone and EDDP. J Anal Toxicol 24:70-72
38. Wolff K, Hay A (1991)Methadone in saliva. Clin Chem 37:1297-1298
39. Shiran MR, Hassanzadeh-Khayyat M, Iqbal MZ, Lagundoye O, Seivewright N, Lennrd MS, Tucker GT, Tostami-Hodjegan A (2005) Can saliva replace plasma for the monitoring of methadone. Ther Drug Monit 27:580-586
40. Wille SMR, Raes E, Lillsunde P, Gunnar T, Laloup M, Samyn N, Christophersen AS, Moeller MR, Hammer KP, Verstraete AG (2009) Relationship between oral fluid and blood concentrations of drugs of abuse in drivers suspected of driving under the influence of drugs. Ther Drug Monit 31:511-519
41. Engblom C, Gunnar T, Rantanen A, Lillsunde P (2007) Driving under the influence of drugs-amphetamine concentrations in oral fluid and whole blood samples. J Anal Toxicol 11:176-280
42. Pfaffe T, Cooper-White J, Beyerlein P, Kostner K, Punyadeera C (2011) Diagnostic potential of saliva: current state and future applications. Clin Chem 57:675-687