Diagnostic potential of saliva: Current state and future applications

Clinical Chemistry

Volumn 57, Issue 5, 2011, Pages 675-687

  Pfaffe, Tina ^a   Cooper White, Justin ^b,c   Beyerlein, Peter ^a   Kostner, Karam ^c,d   Punyadeera, Chamindie ^b,c  

^a TECHNICAL UNIVERSITY OF APPLIED SCIENCES WILDAU   (Germany)

^b Australian Institute for Bioengineering and Nanotechnology   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d MATER HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ENOLASE; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; AMYLASE; ANTIGEN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CARDIAC TROPONIN; CATHEPSIN D; CD40 ANTIGEN; CELL ADHESION MOLECULE; CREATINE KINASE BB; CREATINE KINASE MM; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBRONECTIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; LYSOZYME; MUCIN; MYELOID CELL NUCLEAR DIFFERENTIATION ANTIGEN; PROLINE RICH PROTEIN; PROTEIN P53; PROTEIN S100B; SALIVA PROTEIN; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; SOLUBLE VASCULAR CELL ADHESION MOLECULE 1; TROPONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACTIVE TRANSPORT; ACUTE HEART INFARCTION; ATHEROSCLEROSIS; B LYMPHOCYTE; BIOCHEMISTRY; BLOOD; BREAST CANCER; CANCER DIAGNOSIS; CANCER SURVIVAL; CAPILLARY; CARDIOVASCULAR DISEASE; CHILD; CIRCADIAN RHYTHM; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); DENTAL CARIES; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DIET; DIFFUSION; DIGESTIVE SYSTEM; FLOW RATE; HUMAN; INFLAMMATION; LIQUID CHROMATOGRAPHY; LUBRICATION; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; MOUTH CANCER; MOUTH HYGIENE; MOUTH MUCOSA; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; ODOR; PH; PHYSIOLOGY; PRADER WILLI SYNDROME; PROGNOSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEOMICS; REVIEW; SALIVA; SALIVARY GLAND; SALIVATION; SAMPLING; SCREENING; SERUM; SJOEGREN SYNDROME; STRESS; TANDEM MASS SPECTROMETRY; TASTE; TWO DIMENSIONAL GEL ELECTROPHORESIS; ULTRAFILTRATION;

BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; DIFFUSION; FEMALE; HUMANS; MOUTH MUCOSA; MOUTH NEOPLASMS; PROTEOME; SALIVA; SPECIMEN HANDLING;

EID: 79956152524     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2010.153767     Document Type: Review

References (74)

1. Hofman LF. Human saliva as a diagnostic specimen. J Nutr 2001;131:1621S-5S.
2. Kaufman E, Lamster IB. The diagnostic applications of saliva: a review. Crit Rev Oral Biol Med 2002;13:197-212.
3. Christodoulides N, Mohanty S, Miller CS, Langub MC, Floriano PN, Dharshan P, et al. Application of microchip assay system for the measurement of C-reactive protein in human saliva. Lab Chip 2005;5:261-9. (Pubitemid 40460443)
4. Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis: a review. J Clin Periodontol 2000;27:453-65.
5. Miller CS, King CP Jr, Langub MC, Kryscio RJ, Thomas MV. Salivary biomarkers of existing periodontal disease: a cross-sectional study. J Am Dent Assoc 2006;137:322-9. (Pubitemid 43416225)
6. Veerman EC, Valentijn-Benz M, Nieuw Amerongen AV. Viscosity of human salivary mucins: effect of pH and ionic strength and role of sialic acid. J Biol Buccale 1989;17:297-306.
7. van der Reijden WA, Veerman EC, Amerongen AV. Shear rate dependent viscoelastic behavior of human glandular salivas. Biorheology 1993;30:141-52. (Pubitemid 23224252)
8. Chicharro JL, Lucia A, Perez M, Vaquero AF, Urena R. Saliva composition and exercise. Sports Med 1998;26:17-27. (Pubitemid 28416822)
9. Walsh NP, Laing SJ, Oliver SJ, Montague JC, Walters R, Bilzon JL. Saliva parameters as potential indices of hydration status during acute dehydration. Med Sci Sports Exerc 2004;36:1535-42. (Pubitemid 39202622)
10. Kalk WW, Vissink A, Stegenga B, Bootsma H, Nieuw Amerongen AV, Kallenberg CG. Sialometry and sialochemistry: a non-invasive approach for diagnosing Sjogren's syndrome. Ann Rheum Dis 2002;61:137-44. (Pubitemid 34098429)
11. Edgar WM. Saliva: its secretion, composition and functions. Br Dent J 1992;172:305-12.
12. Ericsson Y. Clinical Investigation of the Salivary Buffering Action. Acta Odontologica Scandinavica 1959;17:131-65.
13. Michelle A, Hopkins J, McLaughlin CW, Johnson S, Warner MQ, LaHart D, Wright JD. Human biology and health. Englewood Cliffs (NJ): Prentice Hall; 1993. 112 p.
14. Schipper RG, Silletti E, Vingerhoeds MH. Saliva as research material: biochemical, physicochemical and practical aspects. Arch Oral Biol 2007;52:1114-35. (Pubitemid 350018725)
15. Hu S, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, et al. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol 2004;25:1423-30.
16. Huq NL, Cross KJ, Ung M, Myroforidis H, Veith PD, Chen D, et al. A review of the salivary proteome and peptidome and saliva-derived peptide therapeutics. Int J Pept Res Ther 2007;13:547-64. (Pubitemid 350060783)
17. Horsfall AC, Rose LM, Maini RN. Autoantibody synthesis in salivary glands of Sjogren's syndrome patients. J Autoimmun 1989;2:559-68.
18. Ryu OH, Atkinson JC, Hoehn GT, Illei GG, Hart TC. Identification of parotid salivary biomarkers in Sjogren's syndrome by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. Rheumatology (Oxford) 2006;45:1077-86. (Pubitemid 44542092)
19. Hu S, Wang J, Meijer J, Leong S, Xie Y, Yu T. Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum 2007;56:3588-600. (Pubitemid 350100692)
20. Hu S, Gao K, Pollard R, Arellano-Garcia M, Zhou H, Zhang L, et al. Preclinical validation of salivary biomarkers for primary Sjogren's syndrome. Arthritis Care Res (Hoboken) 2010;62:1633-8.
21. Young J, Zarcone J, Holsen L, Anderson MC, Hall S, Richman D, et al. A measure of food seeking in individuals with Prader-Willi syndrome. J Intellect Disabil Res 2006;50:18-24.
22. Hu S, Loo JA, Wong DT. Human saliva proteome analysis. Ann NY Acad Sci 2007;1098:323-9. (Pubitemid 47092536)
23. Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics 2005;5:1714-28. (Pubitemid 40593277)
24. Hardt M, Thomas LR, Dixon SE, Newport G, Agabian N, Prakobphol A, et al. Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry 2005;44:2885-99. (Pubitemid 40293663)
25. Vitorino R, Lobo MJC, Ferrer-Correira AJ, Dubin JR, Tomer KB, Domingues PM, Amado FML. Identification of human whole saliva protein components using proteomics. Proteomics 2004;4:1109-15. (Pubitemid 38445969)
26. Scarano E, Fiorita A, Picciotti PM, Passali GC, Calo L, Cabras T, et al. Proteomics of saliva: personal experience. Acta Otorhinolaryngol Ital 2010;30:125-30.
27. Lamkin MS, Oppenheim FG. Structural features of salivary function. Crit Rev Oral Biol Med 1993;4:251-9. (Pubitemid 23207490)
28. Hu S, Loo JA, Wong DT. Human saliva proteome analysis and disease biomarker discovery. Expert Rev Proteomics 2007;4:531-8. (Pubitemid 47347600)
29. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, et al. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res 2008;7:1994-2006.
30. Miller CS, Foley JD, Bailey AL, Campell CL, Humphries RL, Christodoulides N, et al. Current developments in salivary diagnostics. Biomark Med 2010;4:171-89.
31. Marini A, Cabassi E. La saliva: approccio complementare nella diagnostica clinica e nella ricerca biologica. Ann Fac Med Vet Parma 2002;22:295-311.
32. Haeckel R, Hanecke P. Application of saliva for drug monitoring: an in vivo model for transmembrane transport. Eur J Clin Chem Clin Biochem 1996;34:171-91.
33. Vining RF, McGinley RA, Symons RG. Hormones in saliva: mode of entry and consequent implications for clinical interpretation. Clin Chem 1983;29:1752-6. (Pubitemid 13017234)
34. Mostov KE. Transepithelial transport of immunoglobulins. Annu Rev Immunol 1994;12:63-84. (Pubitemid 24140409)
35. Proctor GB, Carpenter GH, Anderson LC, Garrett JR. Nerve-evoked secretion of immunoglobulin A in relation to other proteins by parotid glands in anaesthetized rat. Exp Physiol 2000;85:511-8.
36. Kugler J, Hess M, Haake D. Secretion of salivary immunoglobulin A in relation to age, saliva flow, mood states, secretion of albumin, cortisol, and catecholamines in saliva. J Clin Immunol 1992;12:45-9.
37. Navazesh M. Methods for collecting saliva. Ann NY Acad Sci 1993;694:72-7. (Pubitemid 23298232)
38. Floriano PN, Christodoulides N, Miller CS, Ebersole JL, Spertus J, Rose BG, et al. Use of saliva-based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study. Clin Chem 2009;55:1530-8.
39. Kidwell DA, Holland JC, Athanaselis S. Testing for drugs of abuse in saliva and sweat. J Chromatogr B Biomed Sci Appl 1998;713:111-35. (Pubitemid 28346482)
40. Schramm W, Smith RH, Craig PA, Kidwell DA. Drugs of abuse in saliva: a review. J Anal Toxicol 1992;16:1-9.
41. Groschl M. Current status of salivary hormone analysis. Clin Chem 2008;54:1759-69.
42. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease: reply. N Engl J Med 2005;353:429-30. (Pubitemid 41132355)
43. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43. (Pubitemid 34212626)
44. Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR. C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation 2008;118:2243-51, 4p following 51.
45. Ridker PM. C-reactive protein, inflammation, and cardiovascular disease: clinical update. Tex Heart Inst J 2005;32:384-6. (Pubitemid 41306801)
46. Dillon MC, Opris DC, Kopanczyk R, Lickliter J, Cornwell HN, Bridges EG, et al. Detection of homocysteine and C-reactive protein in the saliva of healthy adults: comparison with blood levels. Biomark Insights 2010;5:57-61.
47. Bowman J, Miller C, Campbell C, Bailey A, Floriano PN, Christodoulides N, et al. Translational research: next generation salivary biomarker cardiovascular devices at point of care. From: International Association of Dental Research/American Association of Dental Research/Canadian Association of Dental Research 87th General Session and Exhibition; 2009 April 1-4, Miami Beach, FL. Available at: http://iadr.confex.com/iadr/2009miami/webprogram/ Paper120255.html.
48. Apple FS, Ler R, Chung AY, Berger MJ, Murakami MM. Point-of-care i-STAT cardiac troponin I for assessment of patients with symptoms suggestive of acute coronary syndrome. Clin Chem 2006;52:322-5. (Pubitemid 43185500)
49. Wilper AP, Woolhandler S, Lasser KE, McCormick D, Cutrona SL, Bor DH, Himmelstein DU. Waits to see an emergency department physician: U.S. trends and predictors, 1997-2004. Health Aff (Millwood) 2008;27:w84-95.
50. Hu S, Wong DTW, inventors. Salivary protein biomarkers for human oral cancer. WIPO patent publication no. WO/2009/055820. 2009 Apr 30 [publication date].
51. Hu S, Arellanno M, Bootheung P, Wang J, Zhou H, Jiang J. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res 2008;14:6246-52.
52. Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen JT. The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. Clin Cancer Res 2000;6:2363-70. (Pubitemid 30399204)
53. Zhang L, Xiao H, Karlan S, Zhou H, Gross J, Elashoff D, et al. Salivary transcriptomic and proteomic biomarkers for breast cancer detection. PLoS ONE 2010;5:e15573.
54. Mandel ID, Kutscher A, Denning CR, Thompson RH Jr, Zegarelli EV. Salivary studies in cystic fibrosis. Am J Dis Child 1967;113:431-8.
55. Kefalides PT. Saliva research leads to new diagnostic tools and therapeutic options. Ann Intern Med 1999;131:991-2. (Pubitemid 30005046)
56. Pepe MS, Feng Z, Janes H, Bossuyt PM, Potter JD. Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. J Natl Cancer Inst 2008;100:1432-8.
57. Levine MJ. Salivary macromolecules: a structure/function synopsis. Ann NY Acad Sci 1993;694:11-6. (Pubitemid 23298226)
58. Bennick A. Salivary proline-rich proteins. Mol Cell Biochem 1982;45:83-99.
59. Walz A, Stuhler K, Wattenberg A, Hawranke E, Meyer HE, Schmalz G, et al. Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics 2006;6:1631-9.
60. Korsrud FR, Brandtzaeg P. Characterization of epithelial elements in human major salivary glands by functional markers: localization of amylase, lactoferrin, lysozyme, secretory component, and secretory immunoglobulins by paired immunofluorescence staining. J Histochem Cytochem 1982;30:657-66. (Pubitemid 13224408)
61. Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem 2003;278:5300-8. (Pubitemid 36801045)
62. Conway Morris A, Kefala K, Wilkinson TS, Moncayo-Nieto OL, Dhaliwal K, Farrell L, et al. Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia. Thorax 2010;65:201-7.
63. Caggiari L, Guidoboni M, Vaccher E, Barzan L, Franchin G, Gloghini A, et al. High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance. Infect Agent Cancer 2007;2:5.
64. Diagnostic Automation/Cortez-Diagnostics. http://diagnosticautomation. com/. (Accessed April 2010).
65. Stone MJ, Waterman MR, Harimoto D, Murray G, Willson N, Platt MR, et al. Serum myoglobin level as diagnostic test in patients with acute myocardial infarction. Br Heart J 1977;39:375-80. (Pubitemid 8080111)
66. Mallat Z, Henry P, Fressonnet R, Alouani S, Scoazec A, Beaufils P, et al. Increased plasma concentrations of interleukin-18 in acute coronary syndromes. Heart 2002;88:467-9. (Pubitemid 35221955)
67. Milani RV, Mehra MR, Endres S, Eigler A, Cooper ES, Lavie CJ Jr, Ventura HO. The clinical relevance of circulating tumor necrosis factor-alpha in acute decompensated chronic heart failure without cachexia. Chest 1996;110:992-5. (Pubitemid 26347615)
68. Aydin M, Tekin IO, Dogan SM, Yildirim N, Arasli M, Sayin MR, Aktop Z. The levels of tumor necrosis factor-alpha and interleukin-6 in patients with isolated coronary artery ectasia. Mediators Inflamm 2009;2009:106145.
69. Straub RH, Zeuner M, Lock G, Scholmerich J, Lang B. High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis. Br J Rheumatol 1997;36:426-32.
70. Conway Morris A, Kefala K, Wilkinson TS, Moncayo-Nieto OL, Dhaliwal K, Farrell L, et al. Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia. Thorax 2010;65:201-7.
71. Caggiari L, Guidoboni M, Vaccher E, Barzan L, Franchin G, Gloghini A, et al. High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance. Infect Agent Cancer 2007;2:5.
72. Castellanos M, Leira R, Serena J, Blanco M, Pedraza S, Castillo J, Davalos A. Plasma cellularfibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke. Stroke 2004;35:1671-6. (Pubitemid 38823645)
73. Nicholson S, Sainsbury JR, Needham GK, Chambers P, Farndon JR, Harris AL. Quantitative assays of epidermal growth factor receptor in human breast cancer: cut-off points of clinical relevance. Int J Cancer 1988;42:36-41.
74. Foekens JA, Look MP, Bolt-de Vries J, Meijer-van Gelder ME, van Putten WL, Klijn JG. Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients. Br J Cancer 1999;79:300-7. (Pubitemid 29002300)