Innate Immunity: Pattern Recognition in Plants

Effectors in Plant-Microbe Interactions

Volumn , Issue , 2011, Pages 1-32

  Chinchilla, Delphine ^a   Boller, Thomas ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

"elicitors"; "pattern triggered immunity" (PTI); BAK1, flg22 signaling; Chimeric receptor; EF Tu, elf 18, Brassicaceae family; MAMPs; Pathogen growth arrest; Pattern recognition receptors (PRRs); Plant immune response pathways; PRR MAMP interactions

Indexed keywords

EID: 84886840661     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119949138.ch1     Document Type: Chapter

References (155)

1. Agorio, A. & Vera, P. (2007) ARGONAUTE4 is required for resistance to Pseudomonas syringae in Arabidopsis. Plant Cell 19, 3778-3790.
2. Albert, M., Jehle, A.K., Lipschis, M., et al. (2010a) Regulation of cell behaviour by plant receptor kinases: pattern recognition receptors as prototypical models. European Journal of Cell Biology 89, 200-207.
3. Albert, M., Jehle, A.K., Mueller, K., et al. (2010b) Arabidopsis thaliana pattern recognition receptors for bacterial elongation factor Tu and flagellin can be combined to form functional chimeric receptors. Journal of Biological Chemistry 285, 19035-19042.
4. Apel, K. & Hirt, H. (2004) Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annual Review of Plant Biology 55, 373-399.
5. Asai, T., Tena, G., Plotnikova, J., et al. (2002) MAP kinase signalling cascade in Arabidopsis innate immunity. Nature 415, 977-983.
6. Aslam, S.N., Newman, M.A., Erbs, G., et al. (2008) Bacterial polysaccharides suppress induced innate immunity by calcium chelation. Current Biology 18, 1078-1083.
7. Aslam, S.N., Erbs, G., Morrissey, K.L., et al. (2009) Microbe-associated molecular pattern (MAMP) signatures, synergy, size and charge: influences on perception or mobility and host defence responses. Molecular Plant Pathology 10, 375-387.
8. Ausubel, F.M. (2005) Are innate immune signaling pathways in plants and animals conserved? Nature Immunology 6, 973-979.
9. Bar, M., Sharfman, M., Ron, M., et al. (2010) BAK1 is required for the attenuation of ethyleneinducing xylanase (Eix)-induced defense responses by the decoy receptor LeEix1. Plant Journal 63, 791-800.
10. Bari, R.&Jones, J. (2009) Role of plant hormones in plant defence responses. Plant Molecular Biology 69, 473-488.
11. Bauer, Z., Gómez-Gómez, L., Boller, T., et al. (2001) Sensitivity of different ecotypes and mutants of Arabidopsis thaliana toward the bacterial elicitor flagellin correlates with the presence of receptor-binding sites. Journal of Biological Chemistry 276, 45669-45676.
12. Baureithel, K., Felix, G., & Boller, T. (1994) Specific, high-affinity binding of chitin fragments to tomato cells and membranes-competitive inhibition of binding by derivatives of chitooligosaccharides and a Nod factor of Rhizobium. Journal of Biological Chemistry 269, 17931- 17938.
13. Bednarek, P., Kwon, C., & Schulze-Lefert, P. (2010) Not a peripheral issue: secretion in plant-microbe interactions. Current Opinion in Plant Biology 13, 378-387.
14. Benschop, J.J., Mohammed, S., O'Flaherty, M., et al. (2007) Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis. Molecular & Cellular Proteomics 6, 1198-1214.
15. Boller, T. (1995) Chemoperception of microbial signals in plant cells. Annual Review of Plant Physiology and Plant Molecular Biology 46, 189-214.
16. Boller, T. & Felix, G. (2009) A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors. Annual Review of Plant Biology 60, 379-406.
17. Boller, T. & He, S.Y. (2009) Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens. Science 324, 742-744.
18. 2(sensor protein kinases. Nature 464, 418-422.
19. Boutrot, F., Segonzac, C., Chang, K.N., et al. (2010) Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1. Proceedings of the National Academy of Sciences of the United States of America 107, 14502-14507.
20. Brutus, A., Sicilia, F., Macone, A., et al. (2010) A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides. Proceedings of the National Academy of Sciences of the United States of America 107, 9452-9457.
21. Chen, H.M., Xue, L., Chintamanani, S., et al. (2009) Ethylene insensitive3 and ethylene insensitive3-like1 repress salicylic acid induction deficient2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell 21, 2527-2540.
22. Chen, X.W., Chern, M.S., Canlas, P.E., et al. (2010) An ATPase promotes autophosphorylation of the pattern recognition receptor XA21 and inhibits XA21-mediated immunity. Proceedings of the National Academy of Sciences of the United States of America 107, 8029-8034.
23. Chinchilla, D., Bauer, Z., Regenass, M., et al. (2006) The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. Plant Cell 18, 465-476.
24. Chinchilla, D., Zipfel, C., Robatzek, S., et al. (2007) A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature 448, 497-500.
25. Chinchilla, D., Shan, L., He, P., et al. (2009) One for all: the receptor-associated kinase BAK1. Trends in Plant Science 14, 535-541.
26. Clay, N.K., Adio, A.M., Denoux, C., et al. (2009) Glucosinolate metabolites required for an Arabidopsis innate immune response. Science 323, 95-101.
27. Colcombet, J. & Hirt, H. (2008) Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes. Biochemical Journal 413, 217-226.
28. Collins, N.C., Thordal-Christensen, H., Lipka, V., et al. (2003) SNARE-protein-mediated disease resistance at the plant cell wall. Nature 425, 973-977.
29. da Silva, F.G., Shen, Y.W., Dardick, C., et al. (2004) Bacterial genes involved in type I secretion and sulfation are required to elicit the rice Xa21-mediated innate immune response. Molecular Plant-Microbe Interactions 17, 593-601.
30. Darvill, A.G. & Albersheim, P. (1984) Phytoalexins and their elicitors-a defense against microbial infection in plants. Annual Review of Plant Physiology and Plant Molecular Biology 35, 243-275.
31. Dodds, P.N. & Rathjen, J.P. (2010) Plant immunity: towards an integrated view of plant-pathogen interactions. Nature Reviews Genetics 11, 539-548.
32. Dunning, F.M., Sun, W., Jansen, K.L., et al. (2007) Identification and mutational analysis of Arabidopsis FLS2 leucine-rich repeat domain residues that contribute to flagellin perception. Plant Cell 19, 3297-3313.
33. Fath, A. & Boller, T. (1996) Solubilization, partial purification, and characterization of a binding site for a glycopeptide elicitor from microsomal membranes of tomato cells. Plant Physiology 112, 1659-1668.
34. Felix, G., Regenass, M., & Boller, T. (1993) Specific perception of subnanomolar concentrations of chitin fragments by tomato cells-induction of extracellular alkalinization, changes in protein phosphorylation, and establishment of a refractory state. Plant Journal 4, 307-316.
35. Felix, G., Duran, J.D., Volko, S., et al. (1999) Plants have a sensitive perception system for the most conserved domain of bacterial flagellin. Plant Journal 18, 265-276.
36. Felix, G. & Boller, T. (2003) Molecular sensing of bacteria in plants-the highly conserved RNAbinding motif RNP-1 of bacterial cold shock proteins is recognized as an elicitor signal in tobacco. Journal of Biological Chemistry 278, 6201-6208.
37. Fliegmann, J., Mithöfer, A., Wanner, G., et al. (2004) An ancient enzyme domain hidden in the putative b-glucan elicitor receptor of soybean may play an active part in the perception of pathogen-associated molecular patterns during broad host resistance. Journal of BiologicalChemistry 279, 1132-1140.
38. Frei dit Frey, N. & Robatzek, S. (2009) Trafficking vesicles: pro or contra pathogens? Current Opinion in Plant Biology 12, 437-443.
39. Garcia-Brugger, A., Lamotte, O., Vandelle, E., et al. (2006) Early signaling events induced by elicitors of plant defenses. Molecular Plant-Microbe Interactions 19, 711-724.
40. Gimenez-Ibanez, S., Hann, D.R., Ntoukakls, V., et al. (2009) AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants. Current Biology 19, 423-429.
41. Gómez-Gómez, L., Felix, G., & Boller, T. (1999) A single locus determines sensitivity to bacterial flagellin in Arabidopsis thaliana. Plant Journal 18, 277-284.
42. Gómez-Gómez, L. & Boller, T. (2000) FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis. Molecular Cell 5, 1003-1011.
43. Gómez-Gómez, L., Bauer, Z. & Boller, T. (2001) Both the extracellular leucine-rich repeat domain and the kinase activity of FLS2 are required for flagellin binding and signaling in Arabidopsis. Plant Cell 13, 1155-1163.
44. Granado, J., Felix, G., & Boller, T. (1995) Perception of fungal sterols in plants-subnanomolar concentrations of ergosterol elicit extracellular alkalinization in tomato cells. Plant Physiology 107, 485-490.
45. Gust, A.A., Biswas, R., Lenz, H.D., et al. (2007) Bacteria-derived peptidoglycans constitute pathogenassociated molecular patterns triggering innate immunity in Arabidopsis. Journal of Biological Chemistry 282, 32338-32348.
46. Han, L., Li, G.J., Yang, K.Y., et al. (2010) Mitogen-activated protein kinase 3 and 6 regulate Botrytis cinerea-induced ethylene production in Arabidopsis. Plant Journal 64, 114-127.
47. Hann, D.R. & Rathjen, J.P. (2007) Early events in the pathogenicity of Pseudomonas syringae on Nicotiana benthamiana. Plant Journal 49, 607-618.
48. Haweker, H., Rips, S., Koiwa, H., et al. (2010) Pattern recognition receptors require N-glycosylation to mediate plant immunity. Journal of Biological Chemistry 285, 4629-4636.
49. Hayashi, F., Smith, K.D., Ozinsky, A., et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099-1103.
50. He, K., Gou, X.P., Yuan, T., et al. (2007) BAK1 and BKK1 regulate Brassinosteroid-dependent growth and Brassinosteroid-independent cell-death pathways. Current Biology 17, 1109-1115.
51. He, Z.H., Wang, Z.Y., Li, J.M., et al. (2000) Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science 288, 2360-2363.
52. Heese, A., Hann, D.R., Gimenez-Ibanez, S., et al. (2007) The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proceedings of the National Academy of Sciences of the United States of America 104, 12217-12222.
53. Huffaker, A., Pearce, G., & Ryan, C.A. (2006) An endogenous peptide signal in Arabidopsis activates components of the innate immune response. Proceedings of the National Academy of Sciences of the United States of America 103, 10098-10103.
54. Husebye, H., Halaas, O., Stenmark, H., et al. (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO Journal 25, 683-692.
55. Ichimura, K., Casais, C., Peck, S.C., et al. (2006) MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis. Journal of Biological Chemistry 281, 36969-36976.
56. Iizasa, E., Mitsutomi, M., & Nagano, Y. (2010) Direct binding of a plant LysM receptor-like kinase, LysM RLK1/CERK1, to chitin in vitro. Journal of Biological Chemistry 285, 2996-3004.
57. Janeway, C.A. & Medzhitov, R. (2002) Innate immune recognition. Annual Review of Immunology 20, 197-216.
58. 2(-associated opening of plasma membrane anion channels. Plant Journal 62, 367-378.
59. Jones, J.D.G. & Dangl, J.L. (2006) The plant immune system. Nature 444, 323-329.
60. Kaku, H., Nishizawa, Y., Ishii-Minami, N., et al. (2006) Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor. Proceedings of the National Academy of Sciences of the United States of America 103, 11086-11091.
61. Kalde, M., Nühse, T.S., Findlay, K., et al. (2007) The syntaxin SYP132 contributes to plant resistance against bacteria and secretion of pathogenesis-related protein 1. Proceedings of the National Academy of Sciences of the United States of America 104, 11850-11855.
62. Kanzaki, H., Saitoh, H., Takahashi, Y., et al. (2008) NbLRK1, a lectin-like receptor kinase protein of Nicotiana benthamiana, interacts with Phytophthora infestans INF1 elicitin and mediates INF1-induced cell death. Planta 228, 977-987.
63. Kemmerling, B., Schwedt, A., Rodriguez, P., et al. (2007) The BRI1-associated kinase 1, BAK1, has a Brassinolide-independent role in plant cell-death control. Current Biology 17, 1116-1122.
64. Knogge, W. & Scheel, D. (2006) LysM receptors recognize friend and foe. Proceedings of the National Academy of Sciences of the United States of America 103, 10829-10830.
65. Kobayashi, M., Ohura, I., Kawakita, K., et al. (2007) Calcium-dependent protein kinases regulate the production of reactive oxygen species by potato NADPH oxidase. Plant Cell 19, 1065-1080.
66. Krol, E., Mentzel, T., Chinchilla, D., et al. (2010) Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2. Journal of Biological Chemistry 285, 13471-13479.
67. Kunze, G., Zipfel, C., Robatzek, S., et al. (2004) The N terminus of bacterial elongation factor Tu elicits innate immunity in Arabidopsis plants. Plant Cell 16, 3496-3507.
68. Kwon, C., Neu, C., Pajonk, S., et al. (2008) Co-option of a default secretory pathway for plant immune responses. Nature 451, 835-840.
69. Lacombe, S., Rougon-Cardoso, A., Sherwood, E., et al. (2010) Interfamily transfer of a plant patternrecognition receptor confers broad-spectrum bacterial resistance. Nature Biotechnology 28, 365-369.
70. Lecourieux, D., Lamotte, O., Bourque, S., et al. (2005) Proteinaceous and oligosaccharidic elicitors induce different calcium signatures in the nucleus of tobacco cells. Cell Calcium 38, 527-538.
71. Lee, S.W., Han, S.W., Bartley, L.E., et al. (2006) Unique characteristics of Xanthomonas oryzae pv. oryzae AvrXa21 and implications for plant innate immunity. Proceedings of the National Academy of Sciences of the United States of America 103, 18395-18400.
72. Lee, S.W., Han, S.W., Sririyanum, M., et al. (2009) A type I-secreted, sulfated peptide triggers Xa21-mediated innate immunity. Science 326, 850-853.
73. Lehti-Shiu, M.D., Zou, C., Hanada, K., et al. (2009) Evolutionary history and stress regulation of plant receptor-like kinase/Pelle genes. Plant Physiology 150, 12-26.
74. Lemmon, M.A. & Schlessinger, J. (2010) Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134.
75. Leulier, F.&Lemaitre, B. (2008) Toll-like receptors - taking an evolutionary approach. Nature Reviews Genetics 9, 165-178.
76. Li, D., Wang, L., Wang, M., et al. (2009a) Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnology Journal 7, 791-806.
77. Li, J., Wen, J.Q., Lease, K.A., et al. (2002) BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell 110, 213-222.
78. Li, J., Zhao-Hui, C., Batoux, M., et al. (2009b) Specific ER quality control components required for biogenesis of the plant innate immune receptor EFR. Proceedings of the National Academy of Sciences of the United States of America 106, 15973-15978.
79. Li, J.M. & Chory, J. (1997) A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90, 929-938.
80. Li, Y., Zhang, Q.Q., Zhang, J.G., et al. (2010) Identification of microRNAs involved in pathogenassociated molecular pattern-triggered plant innate immunity. Plant Physiology 152, 2222-2231.
81. Limpens, E., Franken, C., Smit, P., et al. (2003) LysM domain receptor kinases regulating rhizobial Nod factor-induced infection. Science 302, 630-633.
82. Liu, G.Z., Pit, L.Y., Walker, J.C., et al. (2002) Biochemical characterization of the kinase domain of the rice disease resistance receptor-like kinase XA21. Journal of Biological Chemistry 277, 20264-20269.
83. Liu, Y.D. & Zhang, S.Q. (2004) Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. Plant Cell 16, 3386-3399.
84. Lu, D.P., Wu, S.J., Gao, X.Q., et al. (2010) A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity. Proceedings of the National Academy of Sciences of the United States of America 107, 496-501.
85. Lu, X., Tintor, N., Mentzel, T., et al. (2009) Uncoupling of sustained MAMP receptor signaling from early outputs in an Arabidopsis endoplasmic reticulum glucosidase II allele. Proceedings of the National Academy of Sciences of the United States of America 106, 22522-22527.
86. Mackey, D.&McFall, A.J. (2006) MAMPs and MIMPs: proposed classifications for inducers of innate immunity. Molecular Microbiology 61, 1365-1371.
87. Madsen, E.B., Madsen, L.H., Radutoiu, S., et al. (2003) A receptor kinase gene of the LysM type is involved in legume perception of rhizobial signals. Nature 425, 637-640.
88. Medzhitov, R. & Janeway, C. (2000) Innate immune recognition: mechanisms and pathways. Immunological Reviews 173, 89-97.
89. Meindl, T., Boller, T.,&Felix, G. (1998) The plantwound hormone systemin binds with the N-terminal part to its receptor but needs the C-terminal part to activate it. Plant Cell 10, 1561-1570.
90. Meindl, T., Boller, T., & Felix, G. (2000) The bacterial elicitor flagellin activates its receptor in tomato cells according to the address-message concept. Plant Cell 12, 1783-1794.
91. Melotto, M., Underwood, W., Koczan, J., et al. (2006) Plant stomata function in innate immunity against bacterial invasion. Cell 126, 969-980.
92. Mersmann, S., Bourdais, G., Rietz, S., et al. (2010) Ethylene signaling regulates accumulation of the FLS2 receptor and is required for the oxidative burst contributing to plant immunity. Plant Physiology 154, 391-400.
93. Meyer, D., Pajonk, S., Micali, C., et al. (2009) Extracellular transport and integration of plant secretory proteins into pathogen-induced cell wall compartments. Plant Journal 57, 986-999.
94. Mithöfer, A., Ebel, J., & Felle, H.H. (2005) Cation fluxes cause plasma membrane depolarization involved in b-glucan elicitor-signaling in soybean roots. Molecular Plant-Microbe Interactions 18, 983-990.
95. Miya, A., Albert, P., Shinya, T., et al. (2007) CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 104, 19613-19618.
96. Naito, K., Taguchi, F., Suzuki, T., et al. (2008) Amino acid sequence of bacterial microbe-associated molecular pattern flg22 Is required for virulence. Molecular Plant-Microbe Interactions 21, 1165-1174.
97. Nam, K.H. & Li, J.M. (2002) BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell 110, 203-212.
98. Navarro, L., Zipfel, C., Rowland, O., et al. (2004) The transcriptional innate immune response to flg22.Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis. Plant Physiology 135, 1113-1128.
99. Navarro, L., Dunoyer, P., Jay, F., et al. (2006) A plant miRNA contributes to antibacterial resistance by repressing auxin signaling. Science 312, 436-439.
100. Navarro, L., Jay, F., Nomura, K., et al. (2008) Suppression of the microRNA pathway by bacterial effector proteins. Science 321, 964-967.
101. Nekrasov, V., Li, J., Batoux, M., et al. (2009) Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO Journal 28, 3428-3438.
102. Nishimura, M.T., Stein, M., Hou, B.H., et al. (2003) Loss of a callose synthase results in salicylic acid-dependent disease resistance. Science 301, 969-972.
103. Nühse, T.S., Peck, S.C., Hirt, H., et al. (2000) Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6. Journal of Biological Chemistry 275, 7521- 7526.
104. Nühse, T.S., Boller, T.&Peck, S.C. (2003)Aplasma membrane syntaxin is phosphorylated in response to the bacterial elicitor flagellin. Journal of Biological Chemistry 278, 45248-45254.
105. Nühse, T.S., Bottrill, A.R., Jones, A.M.E., et al. (2007) Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses. Plant Journal 51, 931-940.
106. Nürnberger, T., Nennstiel, D., Jabs, T., et al. (1994) High affinity binding of a fungal oligopeptide elicitor to parsley plasma membranes triggers multiple defense responses. Cell 78, 449-460.
107. 2(and phosphorylation. Journal of BiologicalChemistry 283, 8885-8892.
108. Park, C.J., Han, S.W., Chen, X.W., et al. (2010) Elucidation of Xa21-mediated innate immunity. Cellular Microbiology 12, 1017-1025.
109. Petutschnig, E.K., Jones, A.M.E., Serazetdinova, L., et al. (2010) The lysin motif receptor-like kinase (LysM-RLK) CERK1 Is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation. Journal of Biological Chemistry 285, 28902-28911.
110. Pfund, C., Tans-Kersten, J., Dunning, F.M., et al. (2004) Flagellin is not a major defense elicitor in Ralstonia solanacearum cells or extracts applied to Arabidopsis thaliana. Molecular Plant-Microbe Interactions 17, 696-706.
111. Pitzschke, A., Schikora, A. & Hirt, H. (2009) MAPK cascade signalling networks in plant defence. Current Opinion in Plant Biology 12, 421-426.
112. Postel, S., Küfner, I., Beuter, C., et al. (2010) The multifunctional leucine-rich repeat receptor kinase BAK1 is implicated in Arabidopsis development and immunity. European Journal of Cell Biology 89, 169-174.
113. Preisig, C.L. & Kuc, J.A. (1985) Arachidonic acid-related elicitors of the hypersensitive response in potato and enhancement of their activities by glucans from Phytophthora infestans (Mont) De Bary. Archives of Biochemistry and Biophysics 236, 379-389.
114. Radutoiu, S., Madsen, L.H., Madsen, E.B., et al. (2003) Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases. Nature 425, 585-592.
115. Radutoiu, S., Madsen, L.H., Madsen, E.B., et al. (2007) LysM domains mediate lipochitinoligosaccharide recognition and Nfr genes extend the symbiotic host range. EMBO Journal 26, 3923-3935.
116. Reddy, V.S. & Reddy, A.S.N. (2004) Proteomics of calcium-signaling components in plants. Phytochemistry 65, 1745-1776.
117. Robatzek, S., Chinchilla, D.,&Boller, T. (2006) Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. Genes & Development 20, 537-542.
118. Robatzek, S., Bittel, P., Chinchilla, D., et al. (2007) Molecular identification and characterization of the tomato flagellin receptor LeFLS2, an orthologue of Arabidopsis FLS2 exhibiting characteristically different perception specificities. Plant Molecular Biology 64, 539-547.
119. Ron, M. & Avni, A. (2004) The receptor for the fungal elicitor ethylene-inducing xylanase is a member of a resistance-like gene family in tomato. Plant Cell 16, 1604-1615.
120. Ronald, P.C. & Beutler, B. (2010) Plant and animal sensors of conserved microbial signatures. Science 330, 1061-1064.
121. Ruiz-Ferrer, V. & Voinnet, O. (2009) Roles of plant small RNAs in biotic stress responses. Annual Review of Plant Biology 60, 485-510.
122. Saijo, Y., Tintor, N., Lu, X.L., et al. (2009) Receptor quality control in the endoplasmic reticulum for plant innate immunity. EMBO Journal 28, 3439-3449.
123. Scheer, J.M. & Ryan, C.A. (2002) The systemin receptor SR160 from Lycopersicon peruvianum is a member of the LRR receptor kinase family. Proceedings of the National Academy of Sciences of the United States of America 99, 9585-9590.
124. Schulze, B., Mentzel, T., Jehle, A.K., et al. (2010) Rapid Heteromerization and Phosphorylation of Ligand-activated Plant Transmembrane Receptors and Their Associated Kinase BAK1. Journal of Biological Chemistry 285, 9444-9451.
125. Shan, L., He, P., Li, J., et al. (2008) Bacterial effectors target BAK1 to disrupt MAMP receptor signaling complexes and impede plant innate immunity. Cell Host & Microbe 4, 17-27.
126. Shibuya, N., Kaku, H., Kuchitsu, K., et al. (1993) Identification of a novel high-affinity binding site for N-acetylchitooligosaccharide elicitor in the membrane fraction from suspension-cultured rice cells. FEBS Letters 329, 75-78.
127. Shibuya, N. & Minami, E. (2001) Oligosaccharide signalling for defence responses in plant. Physiological and Molecular Plant Pathology 59, 223-233.
128. Shimizu, T., Nakano, T., Takamizawa, D., et al. (2010) Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice. Plant Journal 64, 204- 214.
129. Shinya, T., Osada, T., Desaki, Y., et al. (2010) Characterization of receptor proteins using affinity cross-linking with biotinylated ligands. Plant and Cell Physiology 51, 262-270.
130. Shiu, S.H. & Bleecker, A.B. (2001) Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. Proceedings of the National Academy of Sciences of the United States of America 98, 10763-10768.
131. Shiu, S.H., Karlowski, W.M., Pan, R.S., et al. (2004) Comparative analysis of the receptor-like kinase family in Arabidopsis and rice. Plant Cell 16, 1220-1234.
132. Song, W.Y., Wang, G.L., Chen, L.L., et al. (1995) A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21. Science 270, 1804-1806.
133. Suarez-Rodriguez, M.C., Adams-Phillips, L., Liu, Y.D., et al. (2007) MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants. Plant Physiology 143, 661-669.
134. Sun, W.X., Dunning, F.M., Pfund, C., et al. (2006) Within-species flagellin polymorphism in Xanthomonas campestris pv. campestris and its impact on elicitation of Arabidopsis FLAGELLIN SENSING2-dependent defenses. Plant Cell 18, 764-779.
135. Takai, R., Isogai, A., Takayama, S., et al. (2008) Analysis of flagellin perception mediated by flg22 receptor OsFLS2 in rice. Molecular Plant-Microbe Interactions 21, 1635-1642.
136. Takemoto, D., Hardham, A.R., & Jones, D.A. (2005) Differences in cell death induction by Phytophthora elicitins are determined by signal components downstream of MAP kinase kinase in different species of Nicotiana and cultivars of Brassica rapa and Raphanus sativus. Plant Physiology 138, 1491-1504.
137. Takeuchi, O. & Akira, S. (2010) Pattern recognition receptors and inflammation. Cell 140, 805- 820.
138. Torres, M.A. (2010) ROS in biotic interactions. Physiologia Plantarum 138, 414-429.
139. Umemoto, N., Kakitani, M., Iwamatsu, A., et al. (1997) The structure and function of a soybean betaglucan-elicitor-binding protein. Proceedings of the National Academy of Sciences of the United States of America 94, 1029-1034.
140. van Loon, L.C., Rep, M., & Pieterse, C.M.J. (2006) Significance of inducible defense-related proteins in infected plants. Annual Review of Phytopathology 44, 135-162.
141. Veronese, P., Nakagami, H., Bluhm, B., et al. (2006) The membrane-anchored BOTRYTIS-INDUCED KINASE1 plays distinct roles in Arabidopsis resistance to necrotrophic and biotrophic pathogens. Plant Cell 18, 257-273.
142. Wan, J.R., Zhang, X.C., Neece, D., et al. (2008) A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis. Plant Cell 20, 471-481.
143. Wang, G.D., Ellendorff, U., Kemp, B., et al. (2008a) A genome-wide functional investigation into the roles of receptor-like proteins in Arabidopsis. Plant Physiology 147, 503-517.
144. Wang, X., Kota, U., He, K., et al. (2008b) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase complex impacts early events in brassinosteroid signaling. Developmental Cell 15, 220-235.
145. Wendehenne, D., Lamotte, O., Frachisse, J.M., et al. (2002) Nitrate efflux is an essential component of the cryptogein signaling pathway leading to defense responses and hypersensitive cell death in tobacco. Plant Cell 14, 1937-1951.
146. Yamaguchi, Y., Pearce, G., & Ryan, C.A. (2006) The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells. Proceedings of the National Academy of Sciences of the United States of America 103, 10104-10109.
147. Yamaguchi, Y., Huffaker, A., Bryan, A.C., et al. (2010) PEPR2 is a second receptor for the Pep1 and Pep2 peptides and contributes to defense responses in Arabidopsis. Plant Cell 22, 508- 522.
148. Yoo, S.D., Cho, Y.H., Tena, G., et al. (2008) Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature 451, 789-795.
149. Zeng, W.Q. & He, S.Y. (2010) A prominent role of the flagellin receptor FLAGELLIN-SENSING2 in mediating stomatal response to Pseudomonas syringae pv tomato DC3000 in Arabidopsis. Plant Physiology 153, 1188-1198.
150. Zeng, W.Q., Melotto, M.,&He, S.Y. (2010) Plant stomata: a checkpoint of host immunity and pathogen virulence. Current Opinion in Biotechnology 21, 599-603.
151. Zhang, J., Li, W., Xiang, T.T., et al. (2010) Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host & Microbe 7, 290-301.
152. Zipfel, C., Robatzek, S., Navarro, L., et al. (2004) Bacterial disease resistance in Arabidopsis through flagellin perception. Nature 428, 764-767.
153. Zipfel, C., Kunze, G., Chinchilla, D., et al. (2006) Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell 125, 749-760.
154. Zipfel, C. (2008) Pattern-recognition receptors in plant innate immunity. Current Opinion in Immunology 20, 10-16.
155. Zipfel, C. & Robatzek, S. (2010) Pathogen-associated molecular pattern-triggered immunity: Veni, vidi. .. ? Plant Physiology 154, 551-554.