Cross-species conservation of endocrine pathways: A critical analysis of tier 1 fish and rat screening assays with 12 model chemicals

Environmental Toxicology and Chemistry

Volumn 32, Issue 5, 2013, Pages 1084-1087

  Ankley, Gerald T ^a   Gray, L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Endocrine pathways; Fish; Mammals; Risk assessment; Toxicity testing

Indexed keywords

ANDROGEN RECEPTOR ANTAGONISTS; ANDROGEN RECEPTORS; ENDOCRINE DISRUPTING CHEMICALS; ENDOCRINE DISRUPTOR; ENDOCRINE PATHWAYS; FUNCTIONAL ASPECTS; METHYL-TESTOSTERONE; TOXICITY TESTING;

CHEMICALS; ENDOCRINOLOGY; FISH; MAMMALS; RATS; RISK ASSESSMENT; SOFTWARE TESTING;

ASSAYS;

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 4,4' ISOPROPYLIDENEDIPHENOL; ENDOCRINE DISRUPTOR; ETHINYLESTRADIOL; FADROZOLE; FENARIMOL; FLUTAMIDE; KETOCONAZOLE; METHOXYCHLOR; METHYLTESTOSTERONE; PROCHLORAZ; TRENBOLONE; UNCLASSIFIED DRUG; VINCOLOZOLIN;

BIOASSAY; CRITICAL ANALYSIS; ENZYME ACTIVITY; ESTROGENIC COMPOUND; FISH; MAMMAL; OPTIMIZATION; REPRODUCTION; SPECIES CONSERVATION; TOXICOLOGY; VERTEBRATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOCRINE FUNCTION; FEMALE; FISH; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PUBERTY; RAT; REPRODUCTION; RISK ASSESSMENT; STEROIDOGENESIS; TOXICITY TESTING;

ANDROGENS; ANIMALS; BIOLOGICAL ASSAY; ENDOCRINE DISRUPTORS; ENDOCRINE SYSTEM; ENVIRONMENTAL POLLUTANTS; FEMALE; FISHES; MALE; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY;

MAMMALIA; RATTUS; VERTEBRATA;

EID: 84876415176     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.2151     Document Type: Article

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