Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone

Environmental Toxicology and Chemistry

Volumn 32, Issue 11, 2013, Pages 2528-2541

  Lalone, Carlie A ^a   Villeneuve, Daniel L ^a   Cavallin, Jenna E ^a   Kahl, Michael D ^a   Durhan, Elizabeth J ^a   Makynen, Elizabeth A ^a   Jensen, Kathleen M ^a   Stevens, Kyle E ^a   Severson, Megan N ^a   Blanksma, Chad A ^a   Flynn, Kevin M ^a   Hartig, Philip C ^b   Woodard, Jonne S ^b   Berninger, Jason P ^c   Norberg King, Teresa J ^a   Johnson, Rodney D ^a   Ankley, Gerald T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL RESEARCH COUNCIL   (United States)

Author keywords

Adverse outcome pathway; Endocrine disruption; Pharmaceutical; Reproductive toxicity; Spironolactone

Indexed keywords

ADVERSE OUTCOMES; CHEMICALS OF CONCERN; ENDOCRINE DISRUPTION; ENVIRONMENTAL CONCERNS; INVERTEBRATE DAPHNIA MAGNA; PHARMACEUTICAL MANUFACTURERS; REPRODUCTIVE TOXICITIES; SPIRONOLACTONE;

ANIMALS; CONSERVATION; DRUG PRODUCTS; TOXICITY;

FISH;

ANDROGEN RECEPTOR; CANRENONE; SPIRONOLACTONE; VITELLOGENIN;

ANDROGEN; ANTAGONISM; BIOMONITORING; DRUG; ENDOCRINE DISRUPTOR; FECUNDITY; FISH; HOMOLOGY; INVERTEBRATE; MOLECULAR ANALYSIS; MONITORING; POLLUTION EXPOSURE; REPRODUCTION; SENSITIVITY ANALYSIS; TOXICITY;

ADVERSE OUTCOME; AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION (PARAMETERS); DAPHNIA MAGNA; DAPHNIA PULEX; DRUG EXPOSURE; DRUG SENSITIVITY; ENVIRONMENTAL IMPACT; FERTILITY; FISH; LIMIT OF DETECTION; MOSQUITO; NONHUMAN; ORYZIAS; PIMEPHALES PROMELAS; PRIORITY JOURNAL; PROTEIN INDUCTION; REPRODUCTION; REPRODUCTIVE TOXICITY; SPECIES; SPECIES COMPARISON; TRANSCRIPTION INITIATION; VITELLINE MEMBRANE; VITELLOGENESIS;

ADVERSE OUTCOME PATHWAY; ENDOCRINE DISRUPTION; PHARMACEUTICAL; REPRODUCTIVE TOXICITY; SPIRONOLACTONE;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; CYPRINIDAE; DAPHNIA; FEMALE; MALE; ORYZIAS; RECEPTORS, ANDROGEN; REPRODUCTION; SPECIES SPECIFICITY; SPIRONOLACTONE; VITELLOGENINS; WATER POLLUTANTS, CHEMICAL;

DAPHNIA; DAPHNIA MAGNA; GAMBUSIA AFFINIS; INVERTEBRATA; ORYZIAS LATIPES; ORYZIINAE; PIMEPHALES PROMELAS; VERTEBRATA;

EID: 84885841869     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.2330     Document Type: Article

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