A substrate-assisted mechanism of nucleophile activation in a ser-his-asp containing C-C bond hydrolase

Biochemistry

Volumn 52, Issue 42, 2013, Pages 7428-7438

  Ruzzini, Antonio C ^a   Bhowmik, Shiva ^b,c   Ghosh, Subhangi ^b   Yam, Katherine C ^a   Bolin, Jeffrey T ^b   Eltis, Lindsay D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Purdue University   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; AMINO ACIDS; CARBON; CATALYSIS; COVALENT BONDS; HYDROLYSIS; NUCLEOPHILES; PROTON TRANSFER; QUANTUM CHEMISTRY;

C-C BOND HYDROLASE; CATALYTIC MECHANISMS; NUCLEOPHILIC CATALYSIS; NUCLEOPHILIC MECHANISMS; PROTON TRANSFER REACTIONS; SOLVENT KINETIC ISOTOPE EFFECTS; STRUCTURAL CHARACTERIZATION; SUBSTRATE BINDING;

HYDROLASES;

2 HYDROXY 2,4 PENTADIENOIC ACID; 2 HYDROXY 6 OXO 6 PHENYLHEXA 2,4 DIENOIC ACID; ASPARTIC ACID; BACTERIAL PROTEIN; BENZOIC ACID; HISTIDINE; HYDROLASE; HYDROXYL GROUP; META CLEAVAGE PRODUCT HYDROLASE; NUCLEOPHILE; PROTEIN DXNB2; SERINE; SERINE DEHYDRATASE; SOLVENT; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; KETONIZATION; LIQUID CHROMATOGRAPHY; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; SPHINGOMONAS; SPHINGOMONAS WITTICHII; TAUTOMERIZATION;

SPHINGOMONAS WITTICHII;

EID: 84886788495     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401156a     Document Type: Article

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