Modeling folate, one-carbon metabolism, and DNA methylation

Nutrition Reviews

Volumn 66, Issue SUPPL.1, 2008, Pages

  Ulrich, Cornelia M ^a   Reed, Michael C ^b   Nijhout, H Frederik ^b  

^a USA   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; PURINE; S ADENOSYLMETHIONINE; THYMIDINE;

CARBON METABOLISM; CONFERENCE PAPER; DNA METHYLATION; DNA POLYMORPHISM; GENE MUTATION; GENE SILENCING; GENOTYPE; NONHUMAN; RISK FACTOR;

DIET; DNA DAMAGE; DNA METHYLATION; EPIGENESIS, GENETIC; FOLIC ACID; GENE SILENCING; HUMANS; NEOPLASMS; NUTRITIONAL STATUS; PROMOTER REGIONS, GENETIC;

EID: 48349135395     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2008.00062.x     Document Type: Conference Paper

References (35)

1. Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr. 2002 132 (Suppl S2413 S2418.
2. Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer. 2005 113 : 825 828.
3. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr. 2002 132 (Suppl S2350 S2355.
4. Ulrich CM. Nutrigenetics in cancer research - folate metabolism and colorectal cancer. J Nutr. 2005 135 : 2698 2702.
5. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006 15 : 189 193.
6. Ulrich CM, Potter JD. Folate and cancer - timing is everything. JAMA. 2007 297 : 2408 2409.
7. Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G. Impact of folate deficiency on DNA stability. J Nutr. 2002 132 (Suppl S2444 S2449.
8. Laird PW. Cancer epigenetics. Hum Mol Genet. 2005 14 : R65-76.
9. Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science. 2003 300 : 455.
10. Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999 21 : 163 167.
11. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994 54 : 4855 4878.
12. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase [letter Nat Genet. 1995 10 : 111 113.
13. Stern LL, Mason JB, Selhub J, Choi SW. Genomic DNA hypomethylation, a Characteristic of most cancers, Is present in peripheral leukocytes Of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev. 2000 9 : 849 853.
14. Friso S, Choi SW, Girelli D, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA. 2002 99 : 5606 5611.
15. Castro R, Rivera I, Ravasco P, et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C->T and 1298A->C mutations are associated with DNA hypomethylation. J Med Genet. 2004 41 : 454 458.
16. Shelnutt KP, Kauwell GP, Gregory JF rd, et al. Methylenetetrahydrofolate reductase 677C->T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem. 2004 15 : 554 560.
17. Ulrich CM, Curtin K, Samowitz W, et al. MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. J Nutr. 2005 135 : 2462 2467.
18. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr. 2000 72 : 998 1003.
19. Pufulete M, Al-Ghnaniem R, Khushal A, et al. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut. 2005 54 : 648 653.
20. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutr. 2004 20 : 63 68.
21. Oyama K, Kawakami K, Maeda K, Ishiguro K, Watanabe G. The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. Anticancer Res. 2004 24 : 649 654.
22. Kang S, Kim JW, Kang GH, et al. Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. Gynecol Oncol. 2005 96 : 173 180.
23. van den Donk M, Van Engeland M, Pellis L, et al. Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2007 16 : 327 333.
24. Slattery ML, Curtin K, Sweeney C, et al. Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int J Cancer. 2007 120 : 656 663.
25. Curtin K, Slattery ML, Ulrich CM, et al. Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis. 2007 28 : 1672 1679.
26. Jung A, Poole EM, Bigler J, Whitton J, Potter JD, Ulrich CM. DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2008 17 : 330 338.
27. Reed MC, Nijhout HF, Neuhouser ML, et al. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr. 2006 136 : 2653 2661.
28. Ulrich CM, Nijhout HF, Reed MC. Mathematical modeling: epidemiology meets systems biology. Cancer Epidemiol Biomarkers Prev. 2006 15 : 827 829.
29. Ulrich CM. Folate and cancer prevention: a closer look at a complex picture. Am J Clin Nutr. 2007 86 : 271 273.
30. Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007 297 : 2351 2359.
31. Nijhout HF, Reed MC, Budu P, Ulrich CM. A mathematical model of the folate cycle: new insights into folate homeostasis. J Biol Chem. 2004 279 : 55008 55016.
32. Nijhout HF, Reed M, Anderson D, Mattingly J, James SJ, Ulrich CM. Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation rate. Epigenetics. 2006 1 : 81 87.
33. Nijhout HF, Reed MC, Lam SL, Shane B, Gregory JF, 3rd., Ulrich CM. In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model. 2006 3 : 40.
34. Nijhout HF, Reed MC, Ulrich CM. A day in the life of cell metabolism. J Biolog Theory. 2007 2 : 124 127.
35. Ulrich CM, Robien K, McLeod HL. Cancer pharmacogenetics: polymorphisms, pathways and beyond. Nat Rev Cancer. 2003 3 : 912 920.