Mitochondrial gene polymorphisms that protect mice from colitis

Gastroenterology

Volumn 145, Issue 5, 2013, Pages

  Bär, Florian ^a,d   Bochmann, Wiebke ^a   Widok, Andrea ^a   Von Medem, Kilian ^a   Pagel, Rene ^a   Hirose, Misa ^a   Yu, Xinhua ^b,c   Kalies, Kathrin ^d   König, Peter ^d   Böhm, Ruwen ^e   Herdegen, Thomas ^e   Reinicke, Anna T ^a   Büning, Jürgen ^a   Lehnert, Hendrik ^a   Fellermann, Klaus ^a   Ibrahim, Saleh ^a   Sina, Christian ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

^c XIAMEN UNIVERSITY   (China)

^d UNIVERSITY OF LÜBECK   (Germany)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Conplastic Inbred Mice; Energy Metabolism; IBD Model; Mitochondrial Dysfunction

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA ACTIN; CYTOCHROME C OXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; ENERGY BALANCE; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENETIC POLYMORPHISM; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; MALE; MITOCHONDRIAL GENE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 84886774010     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.07.015     Document Type: Article

References (42)

1. W.E. Roediger The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet 2 1980 712 715
2. S. Waller, M. Tremelling, and F. Bredin Evidence for association of OCTN genes and IBD5 with ulcerative colitis Gut 55 2006 809 814
3. X. Yu, S. Wieczorek, and A. Franke Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases Genes Immun 10 2009 601 605
4. P.S. Shekhawat, S.R. Srinivas, and D. Matern Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice Mol Genet Metab 92 2007 315 324
5. H. Zhang, X.Y. Kuai, and P. Yu Protective role of uncoupling protein-2 against dextran sodium sulfate-induced colitis J Gastroenterol Hepatol 27 2012 603 608
6. S.Y. Hsieh, T.C. Shih, and C.Y. Yeh Comparative proteomic studies on the pathogenesis of human ulcerative colitis Proteomics 6 2006 5322 5331
7. A. Shkoda, T. Werner, and H. Daniel Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease J Proteome Res 6 2007 1114 1125
8. K.G. Sifroni, C.R. Damiani, and C. Stoffel Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis Mol Cell Biochem 342 2010 111 115
9. S. Santhanam, S. Rajamanickam, and A. Motamarry Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis Inflamm Bowel Dis 18 2012 2158 2168
10. K. Lewis, J. Caldwell, and V. Phan Decreased epithelial barrier function evoked by exposure to metabolic stress and nonpathogenic E. coli is enhanced by TNF-alpha Am J Physiol Gastrointest Liver Physiol 294 2008 G669 G678
11. X. Yu, U. Gimsa, and L. Wester-Rosenlof Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains Genome Res 19 2009 159 165
12. K. Scheffler, M. Krohn, and T. Dunkelmann Mitochondrial DNA polymorphisms specifically modify cerebral beta-amyloid proteostasis Acta Neuropathol 124 2012 199 208
13. C. Sina, A. Arlt, and O. Gavrilova Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB Inflamm Bowel Dis 16 2010 320 331
14. T. Dohi, K. Fujihashi, and H. Kiyono Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis Gastroenterology 119 2000 724 733
15. C. Becker, M.C. Fantini, and M.F. Neurath High resolution colonoscopy in live mice Nat Protoc 1 2006 2900 2904
16. X. Yu, L. Wester-Rosenlof, and U. Gimsa The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse Hum Mol Genet 18 2009 4689 4698
17. K. Scheffler, M. Krohn, and T. Dunkelmann Mitochondrial DNA polymorphisms specifically modify cerebral beta-amyloid proteostasis Acta Neuropathol 124 2012 199 208
18. Y. Chen, and I. Suzuki Effect of uncouplers on endogenous respiration and ferrous iron oxidation in a chemolithoautotrophic bacterium Acidithiobacillus (Thiobacillus) ferrooxidans FEMS Microbiol Lett 237 2004 139 145
19. R. Moreno-Loshuertos, R. Acin-Perez, and P. Fernandez-Silva Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants Nat Genet 38 2006 1261 1268
20. E. Nisoli, S. Falcone, and C. Tonello Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals Proc Natl Acad Sci U S A 101 2004 16507 16512
21. C.O. Elson, R.B. Sartor, and G.S. Tennyson Experimental models of inflammatory bowel disease Gastroenterology 109 1995 1344 1367
22. J. Zhao, J. de Vera, and S. Narushima R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice Gastroenterology 132 2007 1331 1343
23. R. Okamoto, K. Tsuchiya, and Y. Nemoto Requirement of Notch activation during regeneration of the intestinal epithelia Am J Physiol Gastrointest Liver Physiol 296 2009 G23 G35
24. W. Scheppach Effects of short chain fatty acids on gut morphology and function Gut 35 1994 S35 S38
25. C. Gunther, H. Neumann, and M.F. Neurath Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium Gut 62 2013 1062 1071
26. M. Pasparakis Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases Nat Rev Immunol 9 2009 778 788
27. A. Nenci, C. Becker, and A. Wullaert Epithelial NEMO links innate immunity to chronic intestinal inflammation Nature 446 2007 557 561
28. C. Mauro, S.C. Leow, and E. Anso NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration Nat Cell Biol 13 2011 1272 1279
29. K.A. Moore, and I.R. Lemischka Stem cells and their niches Science 311 2006 1880 1885
30. D.K. Podolsky Healing the epithelium: solving the problem from two sides J Gastroenterol 32 1997 122 126
31. L. Eckmann, and A.S. Neish NF-kappaB and mucosal homeostasis Curr Top Microbiol Immunol 349 2011 145 158
32. A. Salminen, J.M. Hyttinen, and K. Kaarniranta AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan J Mol Med (Berl) 89 2011 667 676
33. P.L. Roubertoux, F. Sluyter, and M. Carlier Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice Nat Genet 35 2003 65 69
34. M.S. Sharpley, C. Marciniak, and K. Eckel-Mahan Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition Cell 151 2012 333 343
35. H.M. Hamer, D. Jonkers, and K. Venema Review article: the role of butyrate on colonic function Aliment Pharmacol Ther 27 2008 104 119
36. S. Sanchez-Fidalgo, A. Cardeno, and I. Villegas Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice Eur J Pharmacol 633 2010 78 84
37. A.R. Martin, I. Villegas, and M. Sanchez-Hidalgo The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model Br J Pharmacol 147 2006 873 885
38. J. Bassaganya-Riera, K. Reynolds, and S. Martino-Catt Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease Gastroenterology 127 2004 777 791
39. R. Moreno-Loshuertos, R. Acin-Perez, and P. Fernandez-Silva Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants Nat Genet 38 2006 1261 1268
40. H. Roberts, W.M. Choo, and M. Murphy mit- Mutations in the oli2 region of mitochondrial DNA affecting the 20 000 dalton subunit of the mitochondrial ATPase in Saccharomyces cerevisiae FEBS Lett 108 1979 501 504
41. B. Siegmund, H.A. Lehr, and G. Fantuzzi IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation Proc Natl Acad Sci U S A 98 2001 13249 13254
42. S.E. Nikoulina, N.L. Andon, and K.M. McCowen A primary colonic crypt model enriched in enteroendocrine cells facilitates a peptidomic survey of regulated hormone secretion Mol Cell Proteomics 9 2010 728 741