Protective role of uncoupling protein-2 against dextran sodium sulfate-induced colitis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 27, Issue 3, 2012, Pages 603-608

  Zhang, Hongjie ^a   Kuai, Xiao yi ^a   Yu, Pengli ^a   Lin, Lin ^a   Shi, Ruihua ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Claudin 4; Dextran sodium sulfate colitis; Junctional adhesion molecule 1; Occludin; Reactive oxygen species; Uncoupling protein 2; Zonula 1

Indexed keywords

CLAUDIN 4; DEXTRAN SULFATE; DOCUSATE SODIUM; DRINKING WATER; JUNCTIONAL ADHESION MOLECULE A; OCCLUDIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; ZONULA 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

EID: 84863146923     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.06879.x     Document Type: Article

References (32)

1. Dijkstra G, Moshage H, van Dullemen HM etal. Expression of nitric oxide synthases, and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. J. Pathol. 1998; 186: 416-21.
2. Blackburn AC, Doe WF, Buffinton GD. Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis. Free Radic. Biol. Med. 1998; 25: 305-13.
3. Dykens JA, Baginski TJ. Urinary 8-hydroxydeoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease. Scand. J. Gastroenterol. 1998; 3: 628-36.
4. Cuzzocrea S, Mazzon E, Serraino I etal. Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J. Pineal Res. 2001; 30: 1-12.
5. Pentney PT, Bubenik GA. Melatonin reduces the severity of dextran-induced colitis in mice. J. Pineal Res. 1995; 19: 31-9.
6. Araki Y, Andoh A, Fujiyama Y. The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats. Int. J. Mol. Med. 2003; 12: 125-9.
7. Fleury C, Neverova M, Collins S etal. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 1997; 15: 269-72.
8. Gimeno RE, Dembski M, Weng X etal. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 1997; 46: 900-6.
9. Nedergaard J, Cannon B. The "novel" uncoupling proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions. Exp. Physiol. 2003; 88: 65-84.
10. Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 2001; 52: 159-64.
11. Papa S, Skulachev VP. Reactive oxygen species, mitochondria, apoptosis and aging. Mol. Cell. Biochem. 1997; 174: 305-19.
12. Yu X, Wieczorek S, Franke A etal. Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases. Genes Immun. 2009; 10: 601-5.
13. Cummins EP, Seeballuck F, Keely SJ etal. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 2008; 134: 346-8.
14. Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2007; 2: 541-6.
15. Gommeaux J, Cano C, Garcia S etal. Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol. Cell. Biol. 2007; 27: 2215-28.
16. Oda T. Role of mast cells in dextran sulfate sodium-induced experimental colitis in rats. J. Kyoto Pref. Univ. Med. 1995; 104: 1069-82.
17. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115: 182-205.
18. Su CG, Judge TA, Lichtenstein GR. The role of biological therapy in inflammatory bowel disease. Drugs Today (Barc). 2001; 37: 121-33.
19. Araki Y, Mukaisyo K, Sugihara H, Fujiyama Y, Hattori T. Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice. Oncol. Rep. 2010; 24: 869-74.
20. Mattiasson G, Sullivan PG. The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid. Redox Signal. 2006; 8: 1-38.
21. Mattiasson G, Shamloo M, Gido G etal. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat. Med. 2003; 9: 1062-8.
22. Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc. Natl. Acad. Sci. U.S.A. 2002; 99: 118-22.
23. Ceconi C, Boraso A, Cargnoni A, Ferraric R. Oxidative stress in cardiovascular disease: myth or fact? Arch. Biochem. Biophys. 2003; 420: 217-21.
24. Jones DP. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 2002; 348: 93-112.
25. Harris ML, Schiller HJ, Reilly PM, Donowitz M, Grisham MB, Bulkley GB. Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon? Pharmacol. Ther. 1992; 53: 375-408.
26. Williams JG, Hughes LE, Hallett MB. Toxic oxygen metabolite production by circulating phagocytic cells in inflammatory bowel disease. Gut 1990; 31: 187-93.
27. Grisham MB, Yamada T. Neutrophils, nitrogen oxides, and inflammatory bowel disease. Ann. N. Y. Acad. Sci. 1992; 664: 103-15.
28. McKenzie SJ, Baker MS, Buffinton GD, Doe WF. Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J. Clin. Invest. 1996; 98: 136-41.
29. Rao RK, Li L, Baker RD, Baker SS, Gupta A. Glutathione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer. Am. J. Physiol. 2000; 279: G332-40.
30. Thomas S, Balasubramanian KA. Role of intestine in postsurgical complications: involvement of free radicals. Free Radic. Biol. Med. 2004; 36: 745-56.
31. Vetrano S, Rescigno M, Cera MR etal. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 2008; 135: 173-84.
32. Oshima T, Miwa H, Joh T. Changes in the expression of claudins in active ulcerative colitis. J. Gastroenterol. Hepatol. 2008; 23 (Suppl. 2): S146-50.