Assessing the mammalian toxicity of high-boiling petroleum substances under the rubric of the HPV program

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages

  Gray, Thomas M ^a   Simpson, Barry J ^b   Nicolich, Mark J ^c   Murray, F Jay ^d   Verstuyft, Allen W ^e   Roth, Randy N ^f   McKee, Richard H ^g  

^a AMERICAN PETROLEUM INSTITUTE   (United States)

^b Simpson Toxicology Consulting   (United Kingdom)

^c COGIMET ^*  (United States)

^d Murray and Associates   (United States)

^e Al Verstuyft Consulting LLC   (United States)

^f Roth Toxicology Consulting   (United States)

^g EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

Complex substances; Hazard assessment; High boiling; Petroleum; Polycyclic aromatic hydrocarbons; Quantitative composition activity relationship (QCAR); UVCB

Indexed keywords

ASPHALT; FUEL OIL; HIGH BOILING PETROLEUM SUBSTANCE; LUBRICATING AGENT; PETROLEUM DERIVATIVE; POLYCYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG; WAX;

ACUTE TOXICITY; ARTICLE; BIOREMEDIATION; CARCINOGENICITY; CHEMICAL COMPOSITION; CHROMATOGRAPHY; DEVELOPMENTAL TOXICITY; DRUG REEXPOSURE; ECOTOXICITY; HEALTH PROGRAM; HIGH PRODUCTION VOLUME CHALLENGE PROGRAM; HUMAN; HYDROLYSIS; MAMMALIAN TOXICITY; MUTAGENIC ACTIVITY; MUTAGENICITY; PHOTOLYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE COMPOSITION ACTIVITY RELATIONSHIP MODEL; REPEATED DRUG DOSE; REPRODUCTIVE TOXICITY; SKIN CANCER; STATISTICAL MODEL; TOXICITY; TOXICITY TESTING;

ANIMALIA; BACTERIA (MICROORGANISMS); HUMAN PAPILLOMAVIRUS; MAMMALIA;

COMPLEX SUBSTANCES; HAZARD ASSESSMENT; HIGH-BOILING; PETROLEUM; POLYCYCLIC AROMATIC HYDROCARBONS; QUANTITATIVE COMPOSITION-ACTIVITY RELATIONSHIP (QCAR); UVCB;

ANIMALS; CHEMICAL INDUSTRY; HUMANS; MODELS, STATISTICAL; PETROLEUM; POLYCYCLIC COMPOUNDS; RISK ASSESSMENT; TOXICITY TESTS; TRANSITION TEMPERATURE; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 84886753255     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.11.014     Document Type: Article

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