The development of statistical models to determine the relationship between aromatic-ring class profile and repeat-dose and developmental toxicities of high-boiling petroleum substances

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages

  Nicolich, Mark J ^a   Simpson, Barry J ^b   Jay Murray, F ^c   Roth, Randy N ^d   Gray, Thomas M ^e  

^a COGIMET ^*  (United States)

^b Simpson Toxicology Consulting   (United Kingdom)

^c Murray and Associates   (United States)

^d Roth Toxicology Consulting   (United States)

^e AMERICAN PETROLEUM INSTITUTE   (United States)

Author keywords

Biological models; Dermal; Developmental toxicity; High boiling petroleum substances; HPV Chemical Challenge Program; Mixtures toxicity; Polycyclic aromatic compounds; QCAR modeling; Rat; Repeat dose toxicity

Indexed keywords

HIGH BOILING PETROLEUM SUBSTANCE; PETROLEUM DERIVATIVE; POLYCYCLIC AROMATIC COMPOUND; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; DEVELOPMENTAL TOXICITY; FETUS OUTCOME; FETUS RESORPTION; FETUS WEIGHT; HEALTH PROGRAM; HEMOGLOBIN BLOOD LEVEL; HIGH PRODUCTION VOLUME PROGRAM; LINEAR REGRESSION ANALYSIS; LIVER WEIGHT; NONHUMAN; ORGAN WEIGHT; PETROCHEMICAL INDUSTRY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SKIN TOXICITY; STATISTICAL MODEL; THROMBOCYTE COUNT; THYMUS WEIGHT; TOXICITY TESTING;

HUMAN PAPILLOMAVIRUS; RATTUS;

BIOLOGICAL MODELS; DERMAL; DEVELOPMENTAL TOXICITY; HIGH-BOILING PETROLEUM SUBSTANCES; HPV CHEMICAL CHALLENGE PROGRAM; MIXTURES TOXICITY; POLYCYCLIC AROMATIC COMPOUNDS; QCAR MODELING; RAT; REPEAT-DOSE TOXICITY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEVELOPMENT; FETAL RESORPTION; HEMOGLOBINS; LITTER SIZE; LIVER; MICE; MODELS, STATISTICAL; ORGAN SIZE; PETROLEUM; PLATELET COUNT; POLYCYCLIC HYDROCARBONS, AROMATIC; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; THYMUS GLAND; TOXICITY TESTS; TRANSITION TEMPERATURE;

EID: 84886749207     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.11.015     Document Type: Article

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