The relationship between repeat-dose toxicity and aromatic-ring class profile of high-boiling petroleum substances

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages

  Roth, Randy N ^a   Simpson, Barry J ^b   Nicolich, Mark J ^c   Murray, F Jay ^d   Gray, Thomas M ^e  

^a Roth Toxicology Consulting   (United States)

^b Simpson Toxicology Consulting   (United Kingdom)

^c COGIMET ^*  (United States)

^d Murray and Associates   (United States)

^e AMERICAN PETROLEUM INSTITUTE   (United States)

Author keywords

Biological models; Dermal; High boiling petroleum substances; HPV chemical challenge program; Mixtures toxicity; Polycyclic aromatic compounds; QCAR modeling; Rat; Repeat dose toxicity

Indexed keywords

HIGH BOILING PETROLEUM SUBSTANCE; PETROLEUM DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIC RING CLASS MODEL; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEMOGLOBIN DETERMINATION; LIVER WEIGHT; MALE; MATHEMATICAL MODEL; NONHUMAN; ORGAN WEIGHT; PREDICTIVE VALUE; PRIORITY JOURNAL; RAT; REPEAT DOSE TOXICITY; SENSITIVITY AND SPECIFICITY; SKIN TOXICITY; THROMBOCYTE COUNT; THYMUS WEIGHT; TOXICITY; TOXICITY TESTING;

HUMAN PAPILLOMAVIRUS; RATTUS;

BIOLOGICAL MODELS; DERMAL; HIGH-BOILING PETROLEUM SUBSTANCES; HPV CHEMICAL CHALLENGE PROGRAM; MIXTURES TOXICITY; POLYCYCLIC AROMATIC COMPOUNDS; QCAR MODELING; RAT; REPEAT-DOSE TOXICITY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, STATISTICAL; PETROLEUM; POLYCYCLIC HYDROCARBONS, AROMATIC; TOXICITY TESTS, CHRONIC; TOXICITY TESTS, SUBACUTE; TRANSITION TEMPERATURE;

EID: 84886751542     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.05.010     Document Type: Article

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