The relationship between developmental toxicity and aromatic-ring class profile of high-boiling petroleum substances

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages

  Murray, F Jay ^a   Roth, Randy N ^b   Nicolich, Mark J ^c   Gray, Thomas M ^d   Simpson, Barry J ^e  

^a Murray and Associates   (United States)

^b Roth Toxicology Consulting   (United States)

^c COGIMET ^*  (United States)

^d AMERICAN PETROLEUM INSTITUTE   (United States)

^e Simpson Toxicology Consulting   (United Kingdom)

Author keywords

Biological models; Dermal; Developmental toxicity; High boiling petroleum substances; HPV Challenge Program; Mixtures toxicity; Polycyclic aromatic compounds; QCAR modeling; Rat; UVCB

Indexed keywords

HIGH BOILING PETROLEUM SUBSTANCE; PETROLEUM DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AROMATIC RING CLASS MODEL; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; DISEASE ASSOCIATION; FEMALE; FETAL WELL BEING; FETUS GROWTH; FETUS MALFORMATION; FETUS RESORPTION; FETUS WASTAGE; FETUS WEIGHT; MATHEMATICAL MODEL; NONHUMAN; OSSIFICATION; PREDICTION; PRIORITY JOURNAL; RAT; TERATOGENICITY; TOXICITY TESTING;

HUMAN PAPILLOMAVIRUS; RATTUS;

BIOLOGICAL MODELS; DERMAL; DEVELOPMENTAL TOXICITY; HIGH-BOILING PETROLEUM SUBSTANCES; HPV CHALLENGE PROGRAM; MIXTURES TOXICITY; POLYCYCLIC AROMATIC COMPOUNDS; QCAR MODELING; RAT; UVCB;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FETAL DEVELOPMENT; MODELS, STATISTICAL; PETROLEUM; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; TRANSITION TEMPERATURE;

EID: 84886747972     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.05.003     Document Type: Article

References (32)

1. Altgelt K.H., Boduszynski M.M. Composition and Analysis of Heavy Fractions 1994, Marcel Dekker, Inc.
2. Archibong A.E., Inyang F., Ramesh A., Greenwood M., Nayyar T., Kopsombut P., Hood D.B., Nyanda A.M. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod. Toxicol. 2002, 16:801-808.
3. Blackburn G.R., Roy T.A., Bleicher W.T., Reddy M.V., Mackerer C.R. Comparison of biological and chemical predictors of dermal carcinogenicity of petroleum oils. Poly Arom. Comp. 1996, 11:201-210.
4. Bui Q.Q., Tran M.B., West W.L. A comparative study of the reproductive effects of methadone and benzo(a)pyrene in the pregnant and pseudopregnant rat. Toxicology 1986, 42(2-3):195-204.
5. Choi H., Jedrychowski W., Spengler J., Camann D.E., Whyatt R.M., Rauh V., Tsai W.Y., Perera F.P. International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth. Environ. Health Perspect. 2006, 114(11):1744-1750.
6. Choi H., Rauh V., Garfinkel R., Tu Y., Perera F.P. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction. Environ. Health Perspect. 2008, 116(5):658-665.
7. Crump K. A new method for determining allowable daily intakes. Fund. Appl. Toxicol. 1984, 4:854-871.
8. Davis J.A., Gift J.S., Zhao J. Introduction to benchmark dose methods and U.S. EPA's benchmark dose software (BMDS) version 2.1.1. Toxicol. Appl. Pharmacol. 2011, 254:181-191.
9. Draper N.R., Smith H. Applied Regression Analysis 1998, Wiley and Sons, New York, NY. third ed.
10. Felter S., Dourson M. The inexact science of risk assessment (and implications for risk management). Hum. Ecol. Risk Assess. 1998, 4(2):245-251.
11. Feuston M.H., Mackerer C.R. Developmental toxicity of clarified slurry oil, syntower bottoms, and distillate aromatic extract administered as a single oral dose to pregnant rats. J. Toxicol. Environ. Health 1996, 49:45-66.
12. Feuston M.H., Mackerer C.R. Developmental toxicity study in rats exposed dermally to clarified slurry oil for a limited period of gestation. J. Toxicol. Environ. Health 1996, 49(2):207-220.
13. Feuston M.H., Kerstetter S.L., Singer E.J., Mehlman M.A. Developmental toxicity of clarified slurry oil applied dermally to rats. Toxicol. Ind. Health 1989, 3:587-599.
14. Feuston M.H., Low L.K., Hamilton C.E., Mackerer C.R. Correlation of systemic and developmental toxicities with chemical component classes of refinery streams. Fund. Appl. Toxicol. 1994, 22:622-630.
15. Feuston M.H., Hamilton C.E., Schreiner C.A., Mackerer C.R. Developmental toxicity of dermally applied crude oils in rats. J. Toxicol. Environ. Health 1997, 52:79-93.
16. Feuston M.H., Hamilton C.E., Mackerer C.R. Systemic and developmental toxicity of dermally applied syntower bottoms in rats. Fund. Appl. Toxicol. 1997, 35(2):166-176.
17. Gray T.M., Simpson B.J., Nicolich M.J., Murray F.J., Verstuyft A.W., Roth R.N., McKee R.H. Assessing the mammalian toxicity of high-boiling petroleum substances under the rubric of the HPV program. Regul. Toxicol. Pharmacol. 2013, 67(2S):S4-S9.
18. Jedrychowski W., Perera F.P., Tang D., Stigter L., Mroz E., Flak E., Spengler J., Budzyn-Mrozek D., Kaim I., Jacek R. Impact of barbequed meat consumed in pregnancy on birth outcomes accounting for personal prenatal exposure to airborne polycyclic aromatic hydrocarbons: birth cohort study in Poland. Nutrition 2012, 28(4):372-377.
19. Klimisch H.J., Andreae M., Tillman U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul. Toxicol. Pharmacol. 1997, 25:1-5.
20. McKee R.H., Schreiner C.A., Nicolich M.J., Gray T.M. Genetic toxicity of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 2013, 67(2S):S75-S85.
21. Murray F.J., Gray T.M., Roberts L.G., Roth R.N., Nicolich M.J., Simpson B.J. Evaluating the male and female reproductive toxicity of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 2013, 67(2S):S60-S74.
22. Nicolich M.J., Simpson B.J., Murray F.J., Roth R.N, Gray T.M. The development of statistical models to determine the relationship between aromatic-ring class profile and repeat-dose and developmental toxicities of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 2013, 67(2S):S10-S29.
23. Oreskes N.M., Shrader-Frechette K., Belitz K. Verification, validation and confirmation of numerical models in the earth sciences. Science 1994, 263:641-646.
24. Patterson J., Maier A., Kohrman-Vincent M., Dourson M.L. Peer consultation on relationship between PAC profile and toxicity of petroleum substances. Regul. Toxicol. Pharmacol. 2013, 67(2S):S86-S93.
25. Potter T.L., Simmons K.E. Composition of Petroleum Mixtures Total Petroleum Hydrocarbon Criteria Working Group Series 1998, vol. 2. Amherst Scientific Publishers, Amherst.
26. Roth R.N., Simpson B.J., Nicolich M.J., Murray F.J., Gray T.M. The relationship between repeat-dose toxicity and aromatic-ring class profile of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 2013, 67(2S):S30-S45.
27. Roy T.A., Johnson S.W., Blackburn G.R., Mackerer C.R. Correlation of mutagenic and dermal carcinogenic activities of mineral oils with polycyclic aromatic compound content. Fund. Appl. Toxicol. 1988, 10:466-476.
28. Roy T.A., Blackburn G.R., Mackerer C.R. Evaluation of analytical endpoints to predict carcinogenic potency of mineral oils. Poly Arom. Comp. 1994, 5(1):279-287.
29. Speight J. The Chemistry and Technology of Petroleum 2007, CRC Press, Taylor & Francis Group, Boca Raton. fourth ed.
30. US EPA (U.S. Environmental Protection Agency), 2000. Data Collection and Development on High Production Volume (HPV) Chemicals. Federal Register 65(248). Tuesday, December 26, 81686-81698.
31. US EPA (U.S. Environmental Protection Agency), 2009. Guidance on the development, evaluation, and application of environmental models, EPA/100/K-09/003. <>(accessed 21.04.12). http://www.epa.gov/crem/library/cred_guidance_0309.pdf.
32. US EPA (U.S. Environmental Protection Agency), 2012. Glossary of terms. (> (last updated 02.08.12; accessed 29.01.13). http://www.epa.gov/radon/glossary.html.