Evaluating the male and female reproductive toxicity of high-boiling petroleum substances

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 2, 2013, Pages

  Jay Murray, F ^a   Gray, Thomas M ^b   Roberts, Linda G ^c   Roth, Randy N ^d   Nicolich, Mark J ^e   Simpson, Barry J ^f  

^a Murray and Associates   (United States)

^b AMERICAN PETROLEUM INSTITUTE   (United States)

^c CHEVRON ENERGY TECHNOLOGY COMPANY   (United States)

^d Roth Toxicology Consulting   (United States)

^e COGIMET ^*  (United States)

^f Simpson Toxicology Consulting   (United Kingdom)

Author keywords

Fertility; High boiling petroleum substances; HPV Chemical Challenge Program; Petroleum; Rat; Reproductive toxicity; Sperm; UVCB

Indexed keywords

HIGH BOILING PETROLEUM SUBSTANCE; PETROLEUM; POLYCYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DEVELOPMENTAL TOXICITY; FEMALE; FEMALE GENITAL SYSTEM; HIGH TEMPERATURE; HISTOPATHOLOGY; INDUSTRIAL WASTE; MALE; MALE GENITAL SYSTEM; MALE GENITAL TRACT PARAMETERS; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SKIN TOXICITY; TOXICITY TESTING;

HUMAN PAPILLOMAVIRUS; RATTUS;

FERTILITY; HIGH-BOILING PETROLEUM SUBSTANCES; HPV CHEMICAL CHALLENGE PROGRAM; PETROLEUM; RAT; REPRODUCTIVE TOXICITY; SPERM; UVCB;

ANIMALS; FEMALE; MALE; PETROLEUM; POLYCYCLIC HYDROCARBONS, AROMATIC; REPRODUCTION; TRANSITION TEMPERATURE;

EID: 84886746242     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.04.004     Document Type: Article

References (49)

1. Aman R.P. Use of animal models for detecting specific alterations in reproduction. Fund. Appl. Toxicol. 1982, 2:13-26.
2. Arcaro K.F., Gierthy J.F., Mackerer C.R. Antiestrogenicity of clarified slurry oil and two crude oils in a human breast-cancer cell assay. J. Toxicol. Environ. Health 2001, 62:505-521.
3. Archibong A.E., Inyang F., Ramesh A., Greenwood M., Nayyar T., Kopsombut P., Hood D.B., Nyanda A.M. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo[a]pyrene. Reprod. Toxicol. 2002, 16:801-808.
4. Arikpo G.E., Eja M.E., Enene E.U., Okon S.G., Enyi-Idoh K.H., Etim S.E. Petroleum distillates use in folk medicine in south eastern Nigeria. Internet J. Health 2010, 11(1).
5. Arikpo G.E., Eja M.E., Enyi-Idoh K.H. Self medication in rural Africa: the Nigerian experience. Internet J. Health 2010, 11(1).
6. Blackburn G.R., Deitch R.A., Schreiner C.A., Mackerer C.R. Predicting carcinogenicity of petroleum distillation fractions using a modified Salmonella mutagenicity assay. Cell Biol. Toxicol. 1986, 2:63-84.
7. Borman S.M., Christian P.H., Sipes I.G., Hoyer P.B. Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol. Appl. Pharm. 2000, 167:191-198.
8. Bui Q.Q., Tran M.B., West W.L. A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat. Toxicology 1986, 42:195-204.
9. Chapin R.E., Ross M.D., Lamb J.C. Immersion fixation methods for glycol methacrylate-embedded testes. Toxicol. Pathol. 1984, 12:221-227.
10. Creasy D.M. Evaluation of testicular toxicity in safety evaluation studies: The appropriate use of spermatogenic staging. Toxicol. Pathol. 1997, 25:119-131.
11. Creasy D.M. Evaluation of testicular toxicology: synopsis and discussion of the recommendations proposed by the society of toxicologic pathology. Birth Defects Res. B 2003, 68:408-415.
12. Dent M.P. Strengths and limitations of using repeat-dose toxicity studies to predict effects on fertility. Regul. Toxicol. Pharmacol. 2007, 48:241-258.
13. Dutson S.M., Booth G.M., Schaalje G.B., Castle R.N., Seegmiller R.E. Comparative developmental dermal toxicity and mutagenicity of carbazole and benzo[a]carbazole. Environ. Toxicol. Chem. 1997, 16:2113-2117.
14. Feuston M.H., Hamilton C.E., Mackerer C.R. Oral and dermal administration of clarified slurry oil to male C3H mice. Int. J. Toxicol. 1997, 16:561-570.
15. Feuston M.H., Mackerer C.R., Schreiner C.A., Hamilton C.E. Systemic toxicity of dermally applied crude oils in rats. J. Toxicol. Environ. Health 1997, 51:387-399.
16. Gray, T.M., Simpson B.J., Nicolich M.J., Murray F.J., Verstuyft A.W., Roth R.N., 2013. Assessing the mammalian toxicity of high-boiling petroleum substances under the rubric of the HPV program. Regul. Toxicol. Pharmacol. 67 (2S), S4-S9.
17. Hoberman A.M., Christian M.S., Lovre S., Roth R., Koschier F. Developmental toxicity study of clarified slurry oil (CSO) in the rat. Fund. Appl. Toxicol. 1995, 28:34-40.
18. Igwebuike U., Obidike R., Njoku N., Shoyinka S. Testicular morphology and epididymal sperm reserves of male rats following the withdrawal of Nigerian Qua Iboe Brent crude oil. Vet. Arhiv. 2010, 80:121-128.
19. Inyang F., Ramesh A., Kopsombut P., Niaz M.S., Hood D.B., Nyanda A.M., Archibong A.E. Disruption of testicular steroidogenesis and epididymal function by inhaled benzo[a]pyrene. Reprod. Toxicol. 2003, 17:527-537.
20. Khan S., Martin M., Payne J.F., Rahimtula A.D. Embryotoxic evaluation of Prudhoe Bay crude oil in rats. Toxicol. Lett. 1987, 38:109-114.
21. Klimisch H.J., Andreae M., Tillmann U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul. Toxicol. Pharm. 1997, 25:1-5.
22. Kristensen P., Eilertsen E., Einarsdóttir E., Haugen A., Skaug V., Ovrebø S. Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead. Environ. Health Persp. 1995, 103:588-590.
23. Lanning L.L., et al. Recommended approaches for the evaluation of testicular and epididymal toxicity. Toxicol. Pathol. 2002, 30:507-520.
24. Latendresse J.R., et al. Fixation of testes and eyes using a modified Davidson's fluid: comparison with Bouin' fluid and conventional Davidson's Fluid. Toxicol. Pathol. 2002, 30:524-533.
25. Lockard J.M., Creasy D.M., Chapin R.E., Mann P.C., Barlow N.L., Goodman D.G. Comparative study of the genotoxic properties of Eastern and Western US shale oils, crude petroleum, and coal-derived oil. Mutat. Res. 1982, 102:221-235.
26. Mackenzie K., Angevine D. Infertility in mice exposed in utero to benzo[a]pyrene. Biol. Reprod. 1981, 24:183-191.
27. Martin M.T., Mendez E., Corum D.G., Judson R.S., Kavlock R.J., Rotroff D.M., Dix D.J. Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database. Toxicol. Sci. 2009, 110:181-190.
28. Marty M.S., Allen B., Chapin R.E., Cooper R., Daston G.P., Flaws J.A., Foster P.M.D., Makris S.L., Mylchreest E., Sandler D., Tyl R.W. Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test. Birth Defects Res. B 2009, 86:470-489.
29. Mattison D.R. Difference in sensitivity of rat and mouse primordial oocytes to destruction by polycyclic aromatic hydrocarbons. Chem-Biol. Interact. 1979, 28:133-137.
30. Mazet J.A.K., Gardner I.A., Jessup D.A., Lowenstine L.J. Effects of petroleum on mink applied as a model for reproductive success in sea otters. J. Wildlife Dis. 2001, 37:686-692.
31. Mitchell B.F., Taggart M.H. Are animal models relevant to key aspects of human parturition?. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 297:R525-R545.
32. Mohamed el-S.A., Song W.H., Oh S.A., Park Y.J., You Y.A., Lee S., Choi J.Y., Kim Y.J., Jo I., Pang M.G. The transgenerational impact of benzo[a]pyrene on murine male fertility. Hum. Reprod. 2010, 25:2427-2433.
33. Murray, F.J., Roth R.N., Nicolich M.J., Gray T.M., Simpson B.J., 2013. The relationship between developmental toxicity and aromatic-ring class profile of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 67 (2S), S46-S59.
34. Nicolich, M.J., Simpson B.J., Murray F.J., Roth R.N., Gray T.M., 2013. The development of statistical models to determine the relationship between aromatic-ring class profile and repeat-dose and developmental toxicities of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 67 (2S), S10-S29.
35. Obidike I., Maduabuchi I., Olumuyiwa S. Testicular morphology and cauda epididymal sperm reserves of male rats exposed to Nigerian Qua Iboe crude oil. J. Vet. Sci. 2007, 8:1-5.
36. OECD (Organisation for Economic Co-operation and Development), 2012. OECD Guidelines for the Testing of Chemicals, Section 4, Health Effects. <> (accessed 18.05.12.). http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788.
37. Orisakwe O., Akumka D., Njan A., Afonne O. Testicular toxicity of Nigerian bonny light crude oil in male albino rats. Reprod. Toxicol. 2004, 18:439-442.
38. Ramesh A., Inyang F., Lunstrac D.D., Niaz M.S., Kopsombut P., Jones K.M., Hoode D.B., Hills E.R., Archibong A.E. Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene. Exp. Toxicol. Pathol. 2008, 60:269-280.
39. Rigdon R., Rennels E. Effect of feeding benzpyrene on reproduction in the rat. Experientia 1964, 20:224-226.
40. Roth, R.N., Simpson, B.J., Nicolich, M.J., Murray, F.J., Gray, T.M., 2013. The relationship between repeat-dose toxicity and aromatic-ring class profile of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. 67 (2S), S30-S45.
41. Russell L.D., Ettlin R., Sinha Hikim A.P., Clegg E.D. Histological and histopathological evaluation of the testis 1990, Cache River Press, Clearwater, FL.
42. Sakai T., Takahashi M., Mitsumori K., Yasuhara K., Kawashima K., Mayahara H., Ohno Y. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats - overview of the studies. J. Toxicol. Sci. 2000, 25:1-21.
43. Sanbuissho A., Yoshida M., Hisada S., Sagami F., Kudo S., Kumazawa T., Ube M., Komatsu S., Ohno Y. Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats. J. Toxicol. Sci. 2009, 34:SP1-SP22.
44. Simpson, B., Murray, F.J., Roth, R.N., Nicolich, M.J., Gray, T.M., 2013. Application of statistical models to characterize the repeat-dose and developmental toxicity of high-boiling petroleum substances. Regul. Toxicol. Pharmacol. This issue.
45. Swartz W.J., Mattison D.R. Benzo[a]pyrene inhibits ovulation in C57BL/6N mice. Anat. Rec. 1985, 212:268-276.
46. Takayama S., Akaike M., Kawashima K., Takahashi M., Kurokawa Y. A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats. J. Am. Coll. Toxicol. 1995, 14:266-292.
47. Ulbrich G., Palmer A.K. Detection of effects on male reproduction - a literature survey. J. Am. Coll. Toxicol. 1995, 14:293-327.
48. US Environmental Protection Agency, 2011. Code of Federal Regulations Title 40 - Protection of Environment vol. 32. Title: PART 792 - Good Laboratory Practice Standards, July 7, 2011.
49. US Environmental Protection Agency, 2013. High Production Volume (HPV) Challenge, OECD SIDS Manual Section 3.4, Guidance for Meeting the SIDS Requirements. <> (accessed 22.02.13. http://www.epa.gov/HPV/pubs/general/sidsappb.htm.