The importance of heat flow direction for reproducible and homogeneous freezing of bulk protein solutions

Biotechnology Progress

Volumn 29, Issue 5, 2013, Pages 1212-1221

  Rodrigues, Miguel A ^a   Balzan, Gustavo ^a   Rosa, Mónica ^a   Gomes, Diana ^a   de Azevedo, Edmundo G ^a   Singh, Satish K ^b   Matos, Henrique A ^a   Geraldes, Vítor ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b PFIZER INC   (United States)

Author keywords

Biotherapeutics; Bulk frozen storage; Cryoconcentration; Freeze concentration; Hemoglobin; Natural convection; Proteins; Scalable; Stability; Unidirectional

Indexed keywords

BIOTHERAPEUTICS; CRYOCONCENTRATION; FREEZE-CONCENTRATION; FROZEN STORAGE; SCALABLE; UNIDIRECTIONAL;

COMPUTATIONAL FLUID DYNAMICS; CONVERGENCE OF NUMERICAL METHODS; GEOMETRY; HEMOGLOBIN; NATURAL CONVECTION; PROTEINS; TEMPERATURE CONTROL;

FREEZING;

CALLUNA VULGARIS;

PROTEIN; SOLUTION AND SOLUBILITY; WATER;

CHEMISTRY; CRYSTALLIZATION; FREEZING; HEAT; SOLUTION AND SOLUBILITY; THEORETICAL MODEL;

CRYSTALLIZATION; FREEZING; HOT TEMPERATURE; MODELS, THEORETICAL; PROTEINS; SOLUTIONS; WATER;

EID: 84886751537     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1771     Document Type: Article

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