Effect of freezing rate and dendritic ice formation on concentration profiles of proteins frozen in cylindrical vessels

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1316-1329

  Rodrigues, Miguel A ^a   Miller, Maria A ^a   Glass, Matt A ^a   Singh, Satish K ^b   Johnston, Keith P ^a  

^a The University of Texas at Austin   (United States)

^b PFIZER INC   (United States)

Author keywords

Biotechnology; Content uniformity; Protein formulation; Proteins; Unit operations

Indexed keywords

BOVINE SERUM ALBUMIN; ICE; IMMUNOGLOBULIN G2; PROTEIN; TREHALOSE; IMMUNOGLOBULIN G;

ARTICLE; CONCENTRATION (PARAMETERS); DENSITY GRADIENT; DIFFUSION; FREEZING; SOLUTE; STRUCTURE ANALYSIS; TEMPERATURE; THERMODYNAMICS; ANIMAL; BOVINAE; CHEMISTRY; DEVICES; DRUG PACKAGING; EQUIPMENT DESIGN;

ANIMALS; CATTLE; DRUG PACKAGING; EQUIPMENT DESIGN; FREEZING; ICE; IMMUNOGLOBULIN G; SERUM ALBUMIN, BOVINE; TREHALOSE;

EID: 79951929495     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22383     Document Type: Article

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