A new scaleable freeze-thaw technology for bulk protein solutions

Biotechnology and Applied Biochemistry

Volumn 46, Issue 1, 2007, Pages 13-26

  Shamlou, Parviz A ^a   Breen, Lawrence H ^a   Bell, Willis V ^a   Pollo, Mark ^a   Thomas, Beth Ann ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Bulk protein solution; Freeze thaw; Monoclonal antibody; Protein stability; Recombinant human growth hormone (rhGH); Scaleable technique

Indexed keywords

COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; FREEZING; HORMONES; REFRIGERATION; THAWING;

BULK PROTEIN SOLUTION; FREEZE-THAW; PROTEIN STABILITY; RECOMBINANT HUMAN GROWTH HORMONE (RHGH); SCALEABLE TECHNIQUE;

PROTEINS;

HUMAN GROWTH HORMONE; NITROGEN;

ARTICLE; CIRCULAR DICHROISM; COMPUTATIONAL FLUID DYNAMICS; CONTAINER; CRYOPRESERVATION; FREEZE THAWING; FREEZING; LIGHT SCATTERING; PROTEIN FUNCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIMULATION; TEMPERATURE;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; EQUIPMENT AND SUPPLIES; FREEZING; GROWTH HORMONE; RECOMBINANT PROTEINS;

EID: 33846221423     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20060075     Document Type: Article

References (17)

1. Eckhardt, B. M., Qeswein, J. Q. and Bewley, T. A. (1991) Pharm. Res. 8, 1360-1364
2. Webb, S. D., Webb, J. N., Hughes, T. G., Sesin, D. F. and Kincaid, A. C. (2002) BioPharm. (Duloth, Minn.) 15, 22-34
3. Williams-Smith, D. L., Bray, R. C., Barber, M. J., Tsopankis, A. D. and Vinvent, S. P. (1977) Biochem. J. 167, 593-600
4. Wisniewski, R. (1998) BioPharm. 11, 50-56
5. Maa, Y.-F., Nguyen, P.-A. T. and Hsu, S. W. (1998) J. Pharm. Sci. 87, 152-159
6. Patapoff, T. W. and Overcashier, D. E. (2002) BioPharm. (Duloth, Minn.) 3, 16-21
7. Costantino, H. R., Carrasquillo, K. G., Cordero, R. A., Mumenthaler, M., Hsu, C. C. and Griebenow, K. (1998) J. Pharam. Sci. 87, 1412-1419
8. Bam, N. B., Cleland, J. L., Yang, J., Manning, M. C., Carpenter, J. F., Kelley, R. F. and Randolph, T. W. (1998) J. Pharm. Sci. 87, 1554-1559
9. Pikal, M. J., Dellerman, K. M., Roy, M. L. and Riggin, R. M. (1991) Pharm. Res. 8, 427-436
10. Sarciaux, J.-M., Mansour, S., Hageman, M. J. and Nail, S. L. (1999) J. Pharm. Sci. 88, 1354-1361
11. Pikal-Cleland, K. A., Cleland, J. L., Anchordoquy, T. J. and Carpeneter, F. F. (2002) J. Pharm. Sci. 91, 1969-1979
12. Cao, E., Chen, Y., Cui, Z. and Foster, P. R. (2003) Biotech. Bioeng. 82, 864-690
13. Bennan, J., Bing, F., Boone, M., Fernandez, J., Seely, B., Van Denise, H. and Miller, D. (2002) BioPharm. Int. 22-34
14. Voller, V. R. and Swaminathan, C. R. (1991) Numer. Heat Transfer B 19, 175-189
15. Fluent Inc. (2003) Fluent User's guide, Fluent Inc, Lebanon, NH
16. Ferziger, J. H. and Perić, M. (2002) Computational Methods for Fluid Dynamics, 3rd edn, Springer-Verlag, Heidelberg, London and New York
17. Anderson, J. D. (1995) Computational Fluid Dynamics - The Basics with Applications, McGraw-Hill, New York