Simvastatin nanoemulsion for improved oral delivery: Design, characterisation, in vitro and in vivo studies

Journal of Microencapsulation

Volumn 30, Issue 8, 2013, Pages 771-779

  Chavhan, Sandip S ^a   Petkar, Kailash C ^a   Sawant, Krutika K ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Bioavailability; Factorial design; Hypolipidemic activity; in vitro release; in vivo pharmacokinetics; Nanoemulsion

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OIL; PHOSPHATIDYLCHOLINE; POLOXAMER; SIMVASTATIN; SURFACTANT; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; MALE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; RAT; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; VISCOSITY; ZETA POTENTIAL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BIOLOGICAL AVAILABILITY; CHOLESTEROL; EMULSIONS; MALE; PHARMACEUTICAL VEHICLES; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SOLUBILITY;

EID: 84886741065     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2013.788085     Document Type: Article

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