메뉴 건너뛰기




Volumn 78, Issue 5, 2013, Pages 419-425

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro-Inflammatory Cytokines and Repeats

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; CURCUMIN; CYTOKINE; DNA METHYLTRANSFERASE 1; FOLIC ACID; HISTONE H3; HOLOCARBOXYLASE SYNTHETASE; INTERLEUKIN 6; LIGASE; METHYL CPG BINDING PROTEIN 2; PROTEIN EHMT1; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84886735901     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12108     Document Type: Article
Times cited : (9)

References (54)
  • 1
    • 0018748386 scopus 로고
    • Multiple biotin-dependent carboxylase deficiencies associated with defects in T-cell and B-cell immunity
    • Cowan MJ, Wara DW, Packman S, Yoshino M, Sweetman L, Nyhan W. Multiple biotin-dependent carboxylase deficiencies associated with defects in T-cell and B-cell immunity. Lancet 1979;2:115-8.
    • (1979) Lancet , vol.2 , pp. 115-118
    • Cowan, M.J.1    Wara, D.W.2    Packman, S.3    Yoshino, M.4    Sweetman, L.5    Nyhan, W.6
  • 2
    • 0017862891 scopus 로고
    • Cellular antibody synthesis in thiamin, riboflavin, biotin and folic acid-deficient rats
    • Kumar M, Axelrod AE. Cellular antibody synthesis in thiamin, riboflavin, biotin and folic acid-deficient rats. Proc Soc Exp Biol Med 1978;157:421-3.
    • (1978) Proc Soc Exp Biol Med , vol.157 , pp. 421-423
    • Kumar, M.1    Axelrod, A.E.2
  • 3
    • 2642674445 scopus 로고    scopus 로고
    • Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice
    • Baez-Saldana A, Díaz G, Espinoza B, Ortega E. Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice. Am J Clin Nutr 1998;67:431-7.
    • (1998) Am J Clin Nutr , vol.67 , pp. 431-437
    • Baez-Saldana, A.1    Díaz, G.2    Espinoza, B.3    Ortega, E.4
  • 4
    • 3543089240 scopus 로고    scopus 로고
    • Biotin deficiency blocks thymocyte maturation, accelerates thymus involution, and decreases nose-rump length in mice
    • Baez-Saldana A, Ortega E. Biotin deficiency blocks thymocyte maturation, accelerates thymus involution, and decreases nose-rump length in mice. J Nutr 2004;134:1970-7.
    • (2004) J Nutr , vol.134 , pp. 1970-1977
    • Baez-Saldana, A.1    Ortega, E.2
  • 5
    • 65349144833 scopus 로고    scopus 로고
    • Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice
    • Kuroishi T, Kinbara M, Sato N et al. Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice. J Nutr 2009;139:1031-6.
    • (2009) J Nutr , vol.139 , pp. 1031-1036
    • Kuroishi, T.1    Kinbara, M.2    Sato, N.3
  • 6
    • 4344621459 scopus 로고    scopus 로고
    • Folate deficiency inhibits the proliferation of primary human CD8 + T lymphocytes in vitro
    • Courtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN. Folate deficiency inhibits the proliferation of primary human CD8 + T lymphocytes in vitro. J Immunol 2004;173:3186-92.
    • (2004) J Immunol , vol.173 , pp. 3186-3192
    • Courtemanche, C.1    Elson-Schwab, I.2    Mashiyama, S.T.3    Kerry, N.4    Ames, B.N.5
  • 7
    • 33749644549 scopus 로고    scopus 로고
    • The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?
    • Husemoen LL, Toft U, Fenger M, Jorgensen T, Johansen N, Linneberg A. The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy? Int J Epidemiol 2006;35:954-61.
    • (2006) Int J Epidemiol , vol.35 , pp. 954-961
    • Husemoen, L.L.1    Toft, U.2    Fenger, M.3    Jorgensen, T.4    Johansen, N.5    Linneberg, A.6
  • 8
    • 0036270773 scopus 로고    scopus 로고
    • Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats
    • Kim YI, Hayek M, Mason JB, Meydani SN. Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats. J Nutr 2002;132:1361-7.
    • (2002) J Nutr , vol.132 , pp. 1361-1367
    • Kim, Y.I.1    Hayek, M.2    Mason, J.B.3    Meydani, S.N.4
  • 9
    • 31544483014 scopus 로고    scopus 로고
    • Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women
    • Troen AM, Mitchell B, Sorensen B et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136:189-94.
    • (2006) J Nutr , vol.136 , pp. 189-194
    • Troen, A.M.1    Mitchell, B.2    Sorensen, B.3
  • 11
    • 57349181687 scopus 로고    scopus 로고
    • Biotinylation of histones represses transposable elements in human and mouse cells and cell lines, and in Drosophila melanogaster
    • Chew YC, West JT, Kratzer SJ et al. Biotinylation of histones represses transposable elements in human and mouse cells and cell lines, and in Drosophila melanogaster. J Nutr 2008;138:2316-22.
    • (2008) J Nutr , vol.138 , pp. 2316-2322
    • Chew, Y.C.1    West, J.T.2    Kratzer, S.J.3
  • 12
    • 84877350648 scopus 로고    scopus 로고
    • Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats
    • Xue J, Wijeratne S, Zempleni J. Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats. Epigenetics 2013;8:504-11.
    • (2013) Epigenetics , vol.8 , pp. 504-511
    • Xue, J.1    Wijeratne, S.2    Zempleni, J.3
  • 13
    • 43249125904 scopus 로고    scopus 로고
    • Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus
    • Gralla M, Camporeale G, Zempleni J. Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. J Nutr Biochem 2008;19:400-8.
    • (2008) J Nutr Biochem , vol.19 , pp. 400-408
    • Gralla, M.1    Camporeale, G.2    Zempleni, J.3
  • 15
    • 84892441755 scopus 로고    scopus 로고
    • Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events
    • Li Y, Hassan YI, Moriyama H, Zempleni J. Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events. J Nutr Biochem 2013;24:1446-52.
    • (2013) J Nutr Biochem , vol.24 , pp. 1446-1452
    • Li, Y.1    Hassan, Y.I.2    Moriyama, H.3    Zempleni, J.4
  • 16
    • 39549083972 scopus 로고    scopus 로고
    • Chromatin modifications and their mechanism of action
    • Allis CD, Jenuwein T, Reinberg D, eds. Cold Spring Harbor, NY: Cold Spring Harbor Press, ISBN: 978-0-87969-724-2
    • Kouzarides T, Berger SL. Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D, eds. Epigenetics. Cold Spring Harbor, NY: Cold Spring Harbor Press, 2007:191-209. ISBN: 978-0-87969-724-2.
    • (2007) Epigenetics , pp. 191-209
    • Kouzarides, T.1    Berger, S.L.2
  • 17
    • 84869083957 scopus 로고    scopus 로고
    • K16-biotinylated histone H4 is overrepresented in repeat regions and participates in the repression of transcriptionally competent genes in human Jurkat lymphoid cells
    • Rios-Avila L, Pestinger V, Zempleni J. K16-biotinylated histone H4 is overrepresented in repeat regions and participates in the repression of transcriptionally competent genes in human Jurkat lymphoid cells. J Nutr Biochem 2012;23:1559-64.
    • (2012) J Nutr Biochem , vol.23 , pp. 1559-1564
    • Rios-Avila, L.1    Pestinger, V.2    Zempleni, J.3
  • 18
    • 15444372817 scopus 로고    scopus 로고
    • The profile of repeat-associated histone lysine methylation states in the mouse epigenome
    • Martens JH, O'Sullivan RJ, Braunschweig U et al. The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J 2005;24:800-12.
    • (2005) EMBO J , vol.24 , pp. 800-812
    • Martens, J.H.1    O'Sullivan, R.J.2    Braunschweig, U.3
  • 19
    • 1542513556 scopus 로고    scopus 로고
    • Mobile elements: drivers of genome evolution
    • Kazazian HH Jr. Mobile elements: drivers of genome evolution. Science 2004;303:1626-32.
    • (2004) Science , vol.303 , pp. 1626-1632
    • Kazazian Jr., H.H.1
  • 20
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Waterston RH, Lindblad-Toh K, Birney E et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002;420:520-62.
    • (2002) Nature , vol.420 , pp. 520-562
    • Waterston, R.H.1    Lindblad-Toh, K.2    Birney, E.3
  • 21
    • 80052076294 scopus 로고    scopus 로고
    • Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-kappaB activation
    • Feng D, Zhou Y, Xia M, Ma J. Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-kappaB activation. Inflamm Res 2011;60:817-22.
    • (2011) Inflamm Res , vol.60 , pp. 817-822
    • Feng, D.1    Zhou, Y.2    Xia, M.3    Ma, J.4
  • 22
    • 84871829504 scopus 로고    scopus 로고
    • Folate deficiency enhances the inflammatory response of macrophages
    • Kolb AF, Petrie L. Folate deficiency enhances the inflammatory response of macrophages. Mol Immunol 2013;54:164-72.
    • (2013) Mol Immunol , vol.54 , pp. 164-172
    • Kolb, A.F.1    Petrie, L.2
  • 23
    • 84862318128 scopus 로고    scopus 로고
    • The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models
    • Oshima H, Oshima M. The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol 2012;47:97-106.
    • (2012) J Gastroenterol , vol.47 , pp. 97-106
    • Oshima, H.1    Oshima, M.2
  • 24
    • 84890566212 scopus 로고    scopus 로고
    • The analysis of inflammatory signals in Japanese children with Crohn's disease
    • doi: 10.1111/ped.12159
    • Fujitake Y, Ohstuka Y, Ikuse T et al. The analysis of inflammatory signals in Japanese children with Crohn's disease. Pediatr Int 2013. doi: 10.1111/ped.12159.
    • (2013) Pediatr Int
    • Fujitake, Y.1    Ohstuka, Y.2    Ikuse, T.3
  • 25
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010;140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 26
    • 0036246474 scopus 로고    scopus 로고
    • Biotin supply affects expression of biotin transporters, biotinylation of carboxylases, and metabolism of interleukin-2 in Jurkat cells
    • Manthey KC, Griffin JB, Zempleni J. Biotin supply affects expression of biotin transporters, biotinylation of carboxylases, and metabolism of interleukin-2 in Jurkat cells. J Nutr 2002;132:887-92.
    • (2002) J Nutr , vol.132 , pp. 887-892
    • Manthey, K.C.1    Griffin, J.B.2    Zempleni, J.3
  • 27
    • 0035879908 scopus 로고    scopus 로고
    • Simultaneous determination of methionine and total homocysteine in human plasma by gas chromatography-mass spectrometry
    • Shinohara Y, Hasegawa H, Tagoku K, Hashimoto T. Simultaneous determination of methionine and total homocysteine in human plasma by gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 2001;758:283-8.
    • (2001) J Chromatogr B Biomed Sci Appl , vol.758 , pp. 283-288
    • Shinohara, Y.1    Hasegawa, H.2    Tagoku, K.3    Hashimoto, T.4
  • 28
    • 0028946447 scopus 로고
    • Biotin accounts for only half of the total avidin-binding substances in human serum
    • Mock DM, Lankford GL, Mock NI. Biotin accounts for only half of the total avidin-binding substances in human serum. J Nutr 1995;125:941-6.
    • (1995) J Nutr , vol.125 , pp. 941-946
    • Mock, D.M.1    Lankford, G.L.2    Mock, N.I.3
  • 29
    • 0035013946 scopus 로고    scopus 로고
    • In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release
    • Zempleni J, Helm RM, Mock DM. In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release. J Nutr 2001;131:1479-84.
    • (2001) J Nutr , vol.131 , pp. 1479-1484
    • Zempleni, J.1    Helm, R.M.2    Mock, D.M.3
  • 30
    • 0037120820 scopus 로고    scopus 로고
    • Plasma folate levels and risk of spontaneous abortion
    • George L, Mills JL, Johansson AL et al. Plasma folate levels and risk of spontaneous abortion. JAMA 2002;288:1867-73.
    • (2002) JAMA , vol.288 , pp. 1867-1873
    • George, L.1    Mills, J.L.2    Johansson, A.L.3
  • 31
    • 84881244309 scopus 로고    scopus 로고
    • Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways
    • doi: 10.1038/aps.2013.24
    • Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways. Acta Pharmacol Sin 2013. doi: 10.1038/aps.2013.24.
    • (2013) Acta Pharmacol Sin
    • Meng, Z.1    Yan, C.2    Deng, Q.3    Gao, D.F.4    Niu, X.L.5
  • 32
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem 1995;270:24995-5000.
    • (1995) J Biol Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 33
    • 30044446136 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation
    • Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006;69:195-206.
    • (2006) Mol Pharmacol , vol.69 , pp. 195-206
    • Aggarwal, S.1    Ichikawa, H.2    Takada, Y.3    Sandur, S.K.4    Shishodia, S.5    Aggarwal, B.B.6
  • 34
    • 84886972208 scopus 로고    scopus 로고
    • Biotin
    • Erdman JW Jr, Macdonald I, Zeisel SH, eds. Washington, DC: International Life Sciences Institute, ISBN: 978-0-4709-5917-6
    • Zempleni J, Wijeratne SSK, Kuroishi T. Biotin. In: Erdman JW Jr, Macdonald I, Zeisel SH, eds. Present Knowledge in Nutrition. Washington, DC: International Life Sciences Institute, 2012:587-609. ISBN: 978-0-4709-5917-6.
    • (2012) Present Knowledge in Nutrition , pp. 587-609
    • Zempleni, J.1    Wijeratne, S.S.K.2    Kuroishi, T.3
  • 35
    • 79952533709 scopus 로고    scopus 로고
    • Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes
    • Pestinger V, Wijeratne SSK, Rodriguez-Melendez R, Zempleni J. Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes. J Nutr Biochem 2011;22:328-33.
    • (2011) J Nutr Biochem , vol.22 , pp. 328-333
    • Pestinger, V.1    Wijeratne, S.S.K.2    Rodriguez-Melendez, R.3    Zempleni, J.4
  • 36
    • 77952650770 scopus 로고    scopus 로고
    • Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells
    • Kaur MG, Chew YC, Zempleni J. Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells. J Nutr 2010;140:1086-92.
    • (2010) J Nutr , vol.140 , pp. 1086-1092
    • Kaur, M.G.1    Chew, Y.C.2    Zempleni, J.3
  • 37
    • 0742269630 scopus 로고    scopus 로고
    • Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    • Stabler SP, Allen RH. Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin Chem 2004;50:365-72.
    • (2004) Clin Chem , vol.50 , pp. 365-372
    • Stabler, S.P.1    Allen, R.H.2
  • 38
    • 33646934132 scopus 로고    scopus 로고
    • GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats
    • Buzdin A, Kovalskaya-Alexandrova E, Gogvadze E, Sverdlov E. GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats. Nucleic Acids Res 2006;34:e67.
    • (2006) Nucleic Acids Res , vol.34
    • Buzdin, A.1    Kovalskaya-Alexandrova, E.2    Gogvadze, E.3    Sverdlov, E.4
  • 39
    • 33644828413 scopus 로고    scopus 로고
    • Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions
    • Kovalskaya E, Buzdin A, Gogvadze E, Vinogradova T, Sverdlov E. Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions. Virology 2006;346:373-8.
    • (2006) Virology , vol.346 , pp. 373-378
    • Kovalskaya, E.1    Buzdin, A.2    Gogvadze, E.3    Vinogradova, T.4    Sverdlov, E.5
  • 40
    • 1842748823 scopus 로고    scopus 로고
    • Basel, Switzerland: Marcel Dekker, ISBN: 0-8247-9613-6
    • Thode HC. Testing for Normality. Basel, Switzerland: Marcel Dekker, 2002. ISBN: 0-8247-9613-6.
    • (2002) Testing for Normality
    • Thode, H.C.1
  • 41
    • 0003707560 scopus 로고    scopus 로고
    • 3rd Edn. Hoboken, NJ: John Wiley & Sons, ISBN: 0-471-38926-9
    • Hand HA, Nagaraja HN. Order Statistics. 3rd Edn. Hoboken, NJ: John Wiley & Sons, 2003. ISBN: 0-471-38926-9.
    • (2003) Order Statistics
    • Hand, H.A.1    Nagaraja, H.N.2
  • 43
    • 84877754497 scopus 로고    scopus 로고
    • Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection
    • Allie N, Grivennikov SI, Keeton R et al. Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep 2013;9:1809.
    • (2013) Sci Rep , vol.9 , pp. 1809
    • Allie, N.1    Grivennikov, S.I.2    Keeton, R.3
  • 44
    • 0242577787 scopus 로고    scopus 로고
    • The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells
    • Griffin JB, Rodriguez-Melendez R, Zempleni J. The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells. J Nutr 2003;133:3409-15.
    • (2003) J Nutr , vol.133 , pp. 3409-3415
    • Griffin, J.B.1    Rodriguez-Melendez, R.2    Zempleni, J.3
  • 45
    • 3142660234 scopus 로고    scopus 로고
    • Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-kB, mediating cell survival
    • Rodriguez-Melendez R, Schwab LD, Zempleni J. Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-kB, mediating cell survival. Int J Vitam Nutr Res 2004;74:209-16.
    • (2004) Int J Vitam Nutr Res , vol.74 , pp. 209-216
    • Rodriguez-Melendez, R.1    Schwab, L.D.2    Zempleni, J.3
  • 46
    • 22144432280 scopus 로고    scopus 로고
    • High-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells
    • Rodriguez-Melendez R, Griffin JB, Sarath G, Zempleni J. High-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells. J Nutr 2005;135:1659-66.
    • (2005) J Nutr , vol.135 , pp. 1659-1666
    • Rodriguez-Melendez, R.1    Griffin, J.B.2    Sarath, G.3    Zempleni, J.4
  • 47
    • 38049152741 scopus 로고    scopus 로고
    • In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
    • Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc Natl Acad Sci USA 2007;104:19995-20000.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19995-20000
    • Selhub, J.1    Morris, M.S.2    Jacques, P.F.3
  • 48
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder JA, Walsh CP, Bestor TH. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 1997;13:335-40.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 49
    • 0021920738 scopus 로고
    • Local immune responses
    • Dhar R, Ogra PL. Local immune responses. Br Med Bull 1985;41:28-33.
    • (1985) Br Med Bull , vol.41 , pp. 28-33
    • Dhar, R.1    Ogra, P.L.2
  • 50
    • 79959706214 scopus 로고    scopus 로고
    • Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor
    • Amdekar S, Singh V, Singh R, Sharma P, Keshav P, Kumar A. Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor. J Clin Immunol 2011;31:147-54.
    • (2011) J Clin Immunol , vol.31 , pp. 147-154
    • Amdekar, S.1    Singh, V.2    Singh, R.3    Sharma, P.4    Keshav, P.5    Kumar, A.6
  • 51
    • 84863861008 scopus 로고    scopus 로고
    • Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis
    • Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 2012;51 (Suppl. 5):v3-11.
    • (2012) Rheumatology , vol.51 , Issue.SUPPL. 5
    • Choy, E.1
  • 53
    • 84886730736 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. Arthritis data and statistics. (accessed April 8, 2013)
    • Centers for Disease Control and Prevention. Arthritis data and statistics. http://www.cdc.gov/arthritis/data_statistics.htm (accessed April 8, 2013).
  • 54
    • 84886741268 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. Inflammatory bowel disease. (accessed April 8, 2013)
    • Centers for Disease Control and Prevention. Inflammatory bowel disease. http://www.cdc.gov/ibd/ (accessed April 8, 2013).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.