Preactivated thiomers: Evaluation of gastroretentive minitablets

International Journal of Pharmaceutics

Volumn 456, Issue 2, 2013, Pages 473-479

  Hauptstein, Sabine ^a   Müller, Christiane ^a   Dünnhaupt, Sarah ^a   Laffleur, Flavia ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Gastric; Mucoadhesive drug delivery system; Preactivated thiomers; Rosuvastatin; Swellable polymer

Indexed keywords

2 MERCAPTONICOTINIC ACID; CYSTEINE; NICOTINIC ACID DERIVATIVE; PECTIN; ROSUVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; COVALENT BOND; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; HYDROPHILICITY; IN VITRO STUDY; MOLECULAR STABILITY; MOLECULAR WEIGHT; MUCOADHESION; PH; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET HARDNESS; WATER TRANSPORT;

2-MERCAPTONICOTINIC ACID (CID 673681); GASTRIC; MUCOADHESIVE DRUG DELIVERY SYSTEM; PECTIN (CID 441476); PREACTIVATED THIOMERS; ROSUVASTATIN; SWELLABLE POLYMER;

ANIMALS; CACO-2 CELLS; CELL SURVIVAL; CYSTEINE; DELAYED-ACTION PREPARATIONS; DRUG EVALUATION, PRECLINICAL; GASTRIC MUCOSA; GASTROINTESTINAL AGENTS; HUMANS; NICOTINIC ACIDS; PECTINS; SULFHYDRYL COMPOUNDS; SWINE; TABLETS;

EID: 84886726831     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.08.032     Document Type: Article

References (35)

1. Y. Akiyama, N. Nagahara, E. Nara, M. Kitano, S. Iwasa, I. Yamamoto, J. Azuma, and Y. Ogawa Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites J. Pharm. Pharmacol. 50 1998 159 166 (Pubitemid 28102572)
2. A. Bernkop-Schnurch Thiomers: a new generation of mucoadhesive polymers Adv. Drug Deliv. Rev. 57 2005 1569 1582 (Pubitemid 41443470)
3. A. Bernkop-Schnurch, A.H. Krauland, V.M. Leitner, and T. Palmberger Thiomers: potential excipients for non-invasive peptide delivery systems Eur. J. Pharm. Biopharm. 58 2004 253 263 (Pubitemid 39037233)
4. A. Bernkop-Schnurch, V. Schwarz, and S. Steininger Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm. Res. 16 1999 876 881 (Pubitemid 29284199)
5. J. Carlsson, H. Drevin, and R. Axén Protein thiolation and reversible protein-protein conjugation. N-succinimidyl 3-(2-pyridyldithio) propionate, a new heterobifunctional reagent Biochem. J. 173 1978 723 737 (Pubitemid 9010965)
6. S. Dünnhaupt, J. Barthelmes, C.C. Thurner, C. Waldner, D. Sakloetsakun, and A. Bernkop-Schnürch S-protected thiolated chitosan: synthesis and in vitro characterization Carbohyd. Polym. 90 2012 765 772
7. J. Dwivedi, R. Dwivedi, M.S. Ashawat, I. Singhvi, A. Mehta, U. Chandwani, and O.P. Mahatma Solubility and Dissolution Rate Determination of Rosuvastatin Calcium in Different pH Media Using UV Visible Spectrophotometer 2011 Inventi:ppt/359/311
8. R. Garg, and G. Gupta Progress in controlled gastroretentive delivery systems Trop. J. Pharm. Res. Benin City 2008 1055 1066
9. S. Garg, and S. Sharma Gastroretentive Drug Delivery Systems. Business Briefing: Pharmatech 2003
10. J.F. Goodwin, and S.Y. Choi Quantification of protein solutions with trinitrobenzenesulfonic acid Clin. Chem. 16 1970 24 31
11. N. Hussain, A. Al Masum, S. Akhter, F. Sharmin, and S. Reza Formulation and evaluation of gastr retentive floating tablets of simvastatin using hydrophilic rate retardant Bangladesh Pharm. J. 2012 119 126
12. J. Iqbal, G. Shahnaz, S. Dünnhaupt, C. Müller, F. Hintzen, and A. Bernkop-Schnürch Preactivated thiomers as mucoadhesive polymers for drug delivery Biomaterials 33 2012 1528 1535
13. P. Jennings, C. Koppelstaetter, S. Aydin, T. Abberger, A.M. Wolf, G. Mayer, and W. Pfaller Cyclosporine A induces senescence in renal tubular epithelial cells Am. J. Physiol. Renal. Physiol. 293 2007 F831 F838
14. H.O. Kaila, M.A. Ambasana, R.S. Thakkar, H.T. Saravaia, and A.K. Shah A new improved RP-HPLC method for assay of rosuvastatin calcium in tablets Indian J. Pharm. Sci. 72 2010 592 598
15. C.E. Kast, and A. Bernkop-Schnurch Thiolated polymers - thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates Biomaterials 22 2001 2345 2352 (Pubitemid 32666227)
16. G.R. Kunkel, M. Mehrabian, and H.G. Martinson Contact-site cross-linking agents Mol. Cell. Biochem. 34 1981 3 13
17. V.M. Leitner, M.K. Marschutz, and A. Bernkop-Schnurch Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass Eur. J. Pharm. Sci. 18 2003 89 96 (Pubitemid 36120559)
18. V.M. Leitner, G.F. Walker, and A. Bernkop-Schnurch Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins Eur. J. Pharm. Biopharm. 56 2003 207 214 (Pubitemid 37072104)
19. L. Liu, M.L. Fishman, J. Kost, and K.B. Hicks Pectin-based systems for colon-specific drug delivery via oral route Biomaterials 24 2003 3333 3343 (Pubitemid 36581891)
20. S. Majzoob, F. Atyabi, F. Dorkoosh, K. Kafedjiiski, B. Loretz, and A. Bernkop-Schnurch Pectin-cysteine conjugate: synthesis and in-vitro evaluation of its potential for drug delivery J. Pharm. Pharmacol. 58 2006 1601 1610 (Pubitemid 46051675)
21. P.D. Martin, M.J. Warwick, A.L. Dane, C. Brindley, and T. Short Absolute oral bioavailability of rosuvastatin in healthy white adult male volunteers Clin. Ther. 25 2003 2553 2563 (Pubitemid 37373930)
22. P.D. Martin, M.J. Warwick, A.L. Dane, S.J. Hill, P.B. Giles, P.J. Phillips, and E. Lenz Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers Clin. Ther. 25 2003 2822 2835 (Pubitemid 37510592)
23. R. Norris, and K. Brocklehurst A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2,2′-dipyridyl disulphide as a thiol titrant and reactivity probe Biochem. J. 159 1976 245 257
24. J. O'Brien, I. Wilson, T. Orton, and F. Pognan Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity Eur. J. Biochem. 267 2000 5421 5426
25. G. Perera, J. Barthelmes, and A. Bernkop-Schnurch Novel pectin-4-aminothiophenole conjugate microparticles for colon-specific drug delivery J. Control. Release 145 2010 240 246
26. G. Perera, J. Hombach, and A. Bernkop-Schnurch Hydrophobic thiolation of pectin with 4-aminothiophenol: synthesis and in vitro characterization AAPS PharmSciTech 11 2010 174 180
27. J. Perez-Vilar, and R. Mabolo Gel-forming mucins. Notions from in vitro studies Histol. Histopathol. 22 2007 455 464 (Pubitemid 46647259)
28. S. Perrot, H. Dutertre-Catella, C. Martin, P. Rat, and J.M. Warnet Resazurin metabolism assay is a new sensitive alternative test in isolated pig cornea Toxicol. Sci. 72 2003 122 129 (Pubitemid 36336441)
29. P. Prinderre, C. Sauzet, and C. Fuxen Advances in gastro retentive drug-delivery systems Expert Opin. Drug Deliv. 8 2011 1189 1203
30. D. Quintanar-Guerrero, R. Villalobos-GarcÍa, E. Alvarez-ColÍn, and J.M. Cornejo-Bravo In vitro evaluation of the bioadhesive properties of hydrophobic polybasic gels containing N,N-dimethylaminoethyl methacrylate-co-methyl methacrylate Biomaterials 22 2001 957 961 (Pubitemid 32201446)
31. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv. Drug Deliv. Rev. 48 2001 139 157 (Pubitemid 32434400)
32. J.D. Smart The basics and underlying mechanisms of mucoadhesion Adv. Drug Deliv. Rev. 57 2005 1556 1568 (Pubitemid 41443469)
33. J.D. Smart, I.W. Kellaway, and H.E.C. Worthington An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery J. Pharm. Pharmacol. 36 1984 295 299 (Pubitemid 14101358)
34. N. Thirawong, R.A. Kennedy, and P. Sriamornsak Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength Carbohyd. Polym. 71 2008 170 179 (Pubitemid 350100812)
35. G.M. Whitesides, J.E. Lilburn, and R.P. Szajewski Rates of thiol-disulfide interchange reactions between mono- and dithiols and Ellman's reagent J. Org. Chem. 42 1977 332 338