Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men

Journal of Diabetes Investigation

Volumn 2, Issue 4, 2011, Pages 310-317

  Sakurai, Yuko ^a   Tamura, Yoshifumi ^a   Takeno, Kageumi ^a   Kumashiro, Naoki ^a   Sato, Fumihiko ^a   Kakehi, Saori ^a   Ikeda, Shinichi ^a   Ogura, Yuji ^a   Saga, Norio ^a   Naito, Hisashi ^a   Katamoto, Shizuo ^a   Fujitani, Yoshio ^a   Hirose, Takahisa ^a   Kawamori, Ryuzo ^a   Watada, Hirotaka ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Adiponectin; Intramyocellular lipid; Physical activity

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE;

ADULT; ARTICLE; BODY FAT; CONTROLLED STUDY; EXERCISE; FAT INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE INFUSION RATE; HUMAN; HUMAN EXPERIMENT; INFUSION RATE; INSULIN SENSITIVITY; INTRAMYOCELLULAR LIPID ACCUMULATION; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; MALE; METABOLIC ACTIVATION; NORMAL HUMAN; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SOLEUS MUSCLE; TIBIALIS ANTERIOR MUSCLE; YOUNG ADULT;

EID: 84886721443     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/j.2040-1124.2010.00091.x     Document Type: Article

References (40)

1. Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 2002; 32(Suppl. 3): 14-23.
2. Kelley DE, Goodpaster BH, Storlien L. Muscle triglyceride and insulin resistance. Annu Rev Nutr 2002; 22: 325-346.
3. Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord 2003; 27(Suppl. 3): S6-S11.
4. Bachmann OP, Dahl DB, Brechtel K, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 2001; 50: 2579-2584.
5. Krssak M, Falk Petersen K, Dresner A, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 1999; 42: 113-116.
6. Virkamaki A, Korsheninnikova E, Seppala-Lindroos A, et al. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 2001; 50: 2337-2343.
7. Decombaz J, Schmitt B, Ith M, et al. Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects. Am J Physiol Regul Integr Comp Physiol 2001; 281: R760-R769.
8. Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, et al. Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet. Obes Res 2005; 13: 2088- 2094.
9. Tamura Y, Watada H, Igarashi Y, et al. Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners. Metabolism 2008; 57: 373-379.
10. Tamura Y, Tanaka Y, Sato F, et al. Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2005; 90: 3191-3196.
11. Larson-Meyer DE, Newcomer BR, Hunter GR. Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol 2002; 282: E95-E106.
12. Goodpaster BH, He J, Watkins S, et al. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001; 86: 5755-5761.
13. van Loon LJ, Goodpaster BH. Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. Pflugers Arch 2006; 451: 606-616.
14. Thamer C, Machann J, Bachmann O, et al. Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab 2003; 88: 1785-1791.
15. Dube JJ, Amati F, Stefanovic-Racic M, et al. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol 2008; 294: E882-E888.
16. Ebinuma H, Miyazaki O, Yago H, et al. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta 2006; 372: 47-53.
17. Sato F, Tamura Y, Watada H, et al. Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects. J Clin Endocrinol Metab 2007; 92: 3326-3329.
18. Tamura Y, Watada H, Sato F, et al. Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes Metab 2008; 10: 733-738.
19. Groop LC, Bonadonna RC, DelPrato S, et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989; 84: 205-213.
20. Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 2000; 49: 677-683.
21. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8: 1288- 1295.
22. Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 116: 1784-1792.
23. Pajvani UB, Hawkins M, Combs TP, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004; 279: 12152-12162.
24. Hara K, Horikoshi M, Yamauchi T, et al. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006; 29: 1357-1362.
25. Fisher FF, Trujillo ME, Hanif W, et al. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 2005; 48: 1084-1087.
26. Thamer C, Machann J, Tschritter O, et al. Relationship between serum adiponectin concentration and intramyocellular lipid stores in humans. Horm Metab Res 2002; 34: 646- 649.
27. Weiss R, Dufour S, Groszmann A, et al. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 2003; 88: 2014-2018.
28. Perseghin G, Lattuada G, De Cobelli F, et al. Serum retinolbinding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation. J Clin Endocrinol Metab 2007; 92: 4883-4888.
29. Smith SR, de Jonge L, Zachwieja JJ, et al. Concurrent physical activity increases fat oxidation during the shift to a high-fat diet. Am J Clin Nutr 2000; 72: 131-138.
30. Enevoldsen LH, Simonsen L, Bulow J. Postprandial triacylglycerol uptake in the legs is increased during exercise and post-exercise recovery. J Physiol 2005; 568: 941-950.
31. Turcotte LP, Richter EA, Kiens B. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. Am J Physiol 1992; 262: E791-E799.
32. Goldberg IJ, Eckel RH, Abumrad NA. Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. J Lipid Res 2009; 50(Suppl): S86-S90.
33. Bey L, Hamilton MT. Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity. J Physiol 2003; 551: 673-682.
34. Hamilton MT, Etienne J, McClure WC, et al. Role of local contractile activity and muscle fiber type on LPL regulation during exercise. Am J Physiol 1998; 275: E1016-E1022.
35. Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am J Physiol 1995; 268: E229-E236.
36. Schmitt B, Fluck M, Decombaz J, et al. Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes. Physiol Genomics 2003; 15: 148-157.
37. Perseghin G, Scifo P, Pagliato E, et al. Gender factors affect fatty acids-induced insulin resistance in nonobese humans: effects of oral steroidal contraception. J Clin Endocrinol Metab 2001; 86: 3188-3196.
38. Kiens B, Roepstorff C, Glatz JF, et al. Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender. J Appl Physiol 2004; 97: 1209-1218.
39. Zehnder M, Ith M, Kreis R, et al. Gender-specific usage of intramyocellular lipids and glycogen during exercise. Med Sci Sports Exerc 2005; 37: 1517-1524.
40. Hwang JH, Pan JW, Heydari S, et al. Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging. J Appl Physiol 2001; 90: 1267-1274.