Chlorinated biphenyl quinones and phenyl-2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1

Chemical Research in Toxicology

Volumn 26, Issue 10, 2013, Pages 1474-1485

  Qin, Xiaoyan ^a   Lehmler, Hans Joachim ^a   Teesch, Lynn M ^a   Robertson, Larry W ^a   Duffel, Michael W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' CHLOROPHENYL 2,5 BENZOQUINONE; 4' CHLOROPHENYL 2,5 BENZOQUINONE; 4' CHLOROPHENYL 3,6 DICHLORO 2,5 BENZOQUINONE; BENZOQUINONE DERIVATIVE; BILE ACID; CYSTEINE; ELECTROPHILE; HYDROXYSTEROID; HYDROXYSTEROID SULFOTRANSFERASE; HYDROXYSTEROID SULFOTRANSFERASE SULT2A1; NUCLEOPHILE; NUCLEOTIDE; PHENYL 2,5 BENZOQUINONE; POLYCHLORINATED BIPHENYL DERIVATIVE; PRASTERONE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AEROBIC METABOLISM; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; ENZYME MECHANISM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; PROTEIN DEGRADATION; SULFATION;

BENZOQUINONES; BINDING SITES; BIOCATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DEHYDROEPIANDROSTERONE; HUMANS; KINETICS; METHIONINE; PEPTIDES; POLYCHLORINATED BIPHENYLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SULFOTRANSFERASES; TANDEM MASS SPECTROMETRY;

EID: 84886691714     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400207q     Document Type: Article

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