Structure-Activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status

Drug Metabolism and Disposition

Volumn 37, Issue 5, 2009, Pages 1065-1072

  Liu, Yungang ^a   Smart, Jason T ^a   Song, Yang ^a   Lehmler, Hans Joachim ^a   Robertson, Larry W ^a   Duffel, Michael W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NAPHTHOL; 2,3',4' TRICHLORO BIPHENYL 4 OL; 2,4' DICHLORO BIPHENYL 4 OL; 3,2' DICHLORO BIPHENYL 4 OL; GLUTATHIONE DISULFIDE; POLYCHLORINATED BIPHENYL; PRASTERONE; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 2A3; THIOL; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; HYDROXYLATION; LIVER; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SULFATION;

ANIMALS; ENVIRONMENTAL POLLUTANTS; ENZYME INHIBITORS; GLUTATHIONE; HYDROXYLATION; OXIDATION-REDUCTION; POLYCHLORINATED BIPHENYLS; RATS; RECOMBINANT PROTEINS; REDUCING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES; SULFHYDRYL COMPOUNDS; SULFOTRANSFERASES;

RATTUS;

EID: 66449092829     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.026021     Document Type: Article

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