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Volumn , Issue , 2012, Pages 133-146

Blood-Brain Barrier: Considerations in Drug Development and Delivery

Author keywords

BBB in drug development and delivery; BBB phenotype, an emergent property of the endothelium; BBB transient structural for drug permeability, retaining therapeutic; BBB, unique biological physicochemical characteristics; Drug delivery to brain, severity in CNS disorder pharmacotherapy

Indexed keywords


EID: 84886682685     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118435762.ch8     Document Type: Chapter
Times cited : (2)

References (32)
  • 1
    • 34547637590 scopus 로고    scopus 로고
    • Drug targeting to the brain
    • Pardridge WM. Drug targeting to the brain. Pharm. Res. 2007;24:1733-1744.
    • (2007) Pharm. Res. , vol.24 , pp. 1733-1744
    • Pardridge, W.M.1
  • 2
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005;57:173-185.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 3
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras
    • Stewart PA, Wiley MJ. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev. Biol. 1981;84:183-192.
    • (1981) Dev. Biol. , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 4
    • 37549061456 scopus 로고    scopus 로고
    • A genomic comparison of in vivo and in vitro brain microvascular endothelial cells
    • Calabria AR, Shusta EV. A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J. Cereb. Blood Flow Metab. 2008;28:135-148.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 135-148
    • Calabria, A.R.1    Shusta, E.V.2
  • 5
    • 33645809129 scopus 로고    scopus 로고
    • Perivascular nerves and the regulation of cerebrovascular tone
    • Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J Appl. Physiol. 2006;100:1059-1064.
    • (2006) J Appl. Physiol. , vol.100 , pp. 1059-1064
    • Hamel, E.1
  • 6
    • 35548969443 scopus 로고    scopus 로고
    • Glial regulation of the cerebral microvasculature
    • Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat. Neurosci. 2007;10:1369-1376.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1369-1376
    • Iadecola, C.1    Nedergaard, M.2
  • 8
    • 41249098129 scopus 로고    scopus 로고
    • MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis
    • Hjort N, Wu O, Ashkanian M, Solling C, Mouridsen K, Christensen S, Gyldensted C, Andersen G, Ostergaard L. MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis. Stroke 2008;39:1025-1028.
    • (2008) Stroke , vol.39 , pp. 1025-1028
    • Hjort, N.1    Wu, O.2    Ashkanian, M.3    Solling, C.4    Mouridsen, K.5    Christensen, S.6    Gyldensted, C.7    Andersen, G.8    Ostergaard, L.9
  • 9
    • 35348903108 scopus 로고    scopus 로고
    • Pathophysiology of the blood-brain barrier: animal models and methods
    • Hawkins BT, Egleton RD. Pathophysiology of the blood-brain barrier: animal models and methods. Curr. Top Dev. Biol. 2008;80:277-309.
    • (2008) Curr. Top Dev. Biol. , vol.80 , pp. 277-309
    • Hawkins, B.T.1    Egleton, R.D.2
  • 10
    • 33846590017 scopus 로고    scopus 로고
    • Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia
    • Nagaraja TN, Keenan KA, Brown SL, Fenstermacher JD, Knight RA. Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia. Neurol. Res. 2007;29:78-80.
    • (2007) Neurol. Res. , vol.29 , pp. 78-80
    • Nagaraja, T.N.1    Keenan, K.A.2    Brown, S.L.3    Fenstermacher, J.D.4    Knight, R.A.5
  • 11
    • 46949098349 scopus 로고    scopus 로고
    • Modulation of p-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    • Miller DS, Bauer B, Hartz AM. Modulation of p-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. Pharmacol. Rev. 2008;60:196-209.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 196-209
    • Miller, D.S.1    Bauer, B.2    Hartz, A.M.3
  • 12
    • 33646754516 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: expression and function in the central nervous system
    • Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol. Rev. 2006;58:140-161.
    • (2006) Pharmacol. Rev. , vol.58 , pp. 140-161
    • Dallas, S.1    Miller, D.S.2    Bendayan, R.3
  • 13
    • 34250221510 scopus 로고    scopus 로고
    • Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm
    • Gerstner ER, Fine RL. Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm. J. Clin. Oncol. 2007;25:2306-2312.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2306-2312
    • Gerstner, E.R.1    Fine, R.L.2
  • 14
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Loscher W, Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 2005;6:591-602.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 16
    • 42449100856 scopus 로고    scopus 로고
    • Progress in brain penetration evaluation in drug discovery and development
    • Liu X, Chen C, Smith BJ. Progress in brain penetration evaluation in drug discovery and development. J. Pharmacol. Exp. Ther. 2008;325:349-356.
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , pp. 349-356
    • Liu, X.1    Chen, C.2    Smith, B.J.3
  • 17
    • 12344322943 scopus 로고    scopus 로고
    • How to measure drug transport across the blood-brain barrier
    • Bickel U. How to measure drug transport across the blood-brain barrier. NeuroRx. 2005;2:15-26.
    • (2005) NeuroRx. , vol.2 , pp. 15-26
    • Bickel, U.1
  • 18
    • 0035703732 scopus 로고    scopus 로고
    • The roles of P-glycoprotein and MRP1 in the blood-brain and bloodcerebrospinal fluid barriers
    • Schinkel AH. The roles of P-glycoprotein and MRP1 in the blood-brain and bloodcerebrospinal fluid barriers. Adv. Exp. Med. Biol. 2001;500:365-372.
    • (2001) Adv. Exp. Med. Biol. , vol.500 , pp. 365-372
    • Schinkel, A.H.1
  • 19
    • 0031965788 scopus 로고    scopus 로고
    • Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
    • discussion 1099-1100
    • Kroll RA, Neuwelt EA. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 1998;42:1083-1099; discussion 1099-1100.
    • (1998) Neurosurgery , vol.42 , pp. 1083-1099
    • Kroll, R.A.1    Neuwelt, E.A.2
  • 20
    • 0038399929 scopus 로고    scopus 로고
    • Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport
    • Borlongan CV, Emerich DF. Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport. Brain Res. Bull. 2003;60:297-306.
    • (2003) Brain Res. Bull. , vol.60 , pp. 297-306
    • Borlongan, C.V.1    Emerich, D.F.2
  • 21
    • 42449149172 scopus 로고    scopus 로고
    • Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
    • Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol. Pharmacol. 2008;73:1444-1453.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 1444-1453
    • Bauer, B.1    Hartz, A.M.2    Pekcec, A.3    Toellner, K.4    Miller, D.S.5    Potschka, H.6
  • 22
    • 33845937770 scopus 로고    scopus 로고
    • Structure-brain exposure relationships
    • Hitchcock SA, Pennington LD. Structure-brain exposure relationships. J. Med. Chem. 2006;49:7559-7583.
    • (2006) J. Med. Chem. , vol.49 , pp. 7559-7583
    • Hitchcock, S.A.1    Pennington, L.D.2
  • 23
    • 34547645206 scopus 로고    scopus 로고
    • Blood-brain barrier transport of non-viral gene and RNAi therapeutics
    • Boado RJ. Blood-brain barrier transport of non-viral gene and RNAi therapeutics. Pharm. Res. 2007;24:1772-1787.
    • (2007) Pharm. Res. , vol.24 , pp. 1772-1787
    • Boado, R.J.1
  • 24
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptormediation
    • Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via receptormediation. Pharm. Res. 2007;24:1759-1771.
    • (2007) Pharm. Res. , vol.24 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 25
    • 35848935409 scopus 로고    scopus 로고
    • Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology
    • Xia CF, Zhang Y, Zhang Y, Boado RJ, Pardridge WM. Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology. Pharm. Res. 2007;24:2309-2316.
    • (2007) Pharm. Res. , vol.24 , pp. 2309-2316
    • Xia, C.F.1    Zhang, Y.2    Zhang, Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 27
    • 34250665873 scopus 로고    scopus 로고
    • Targeted delivery of proteins across the blood-brain barrier
    • Spencer BJ, Verma IM. Targeted delivery of proteins across the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 2007;104:7594-7599.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 7594-7599
    • Spencer, B.J.1    Verma, I.M.2
  • 28
    • 17644364388 scopus 로고    scopus 로고
    • Dynamics of CNS barriers: evolution, differentiation, and modulation
    • Abbott NJ. Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol. Neurobiol. 2005;25:5-23.
    • (2005) Cell Mol. Neurobiol. , vol.25 , pp. 5-23
    • Abbott, N.J.1
  • 29
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the bloodbrain barrier
    • Abbott NJ, Ronnback L, and Hansson E. Astrocyte-endothelial interactions at the bloodbrain barrier. Nat. Rev. Neurosci. 2006;7:41-53.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 30
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: the problems and the possibilities
    • Begley DJ. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol. Ther. 2004;104:29-45.
    • (2004) Pharmacol. Ther. , vol.104 , pp. 29-45
    • Begley, D.J.1
  • 32
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57:178-201.
    • (2008) Neuron. , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.