메뉴 건너뛰기




Volumn 25, Issue 11, 2013, Pages 1095-1103

Progesterone protective effects in neurodegeneration and neuroinflammation

Author keywords

Anti inflammatory effects; Experimental autoimmune encephalomyelitis; Neuroprotection; Progesterone; Wobbler mouse

Indexed keywords

CD11B ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE TYPE 2; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROGESTERONE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; GESTAGEN; NEUROPROTECTIVE AGENT;

EID: 84886669862     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12043     Document Type: Review
Times cited : (48)

References (75)
  • 1
    • 34548610385 scopus 로고    scopus 로고
    • Progesterone: therapeutic opportunities for neuroprotection and myelin repair
    • Schumacher M, Guennoun R, Stein DG, De Nicola AF. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol Ther 2007; 116: 77-106.
    • (2007) Pharmacol Ther , vol.116 , pp. 77-106
    • Schumacher, M.1    Guennoun, R.2    Stein, D.G.3    De Nicola, A.F.4
  • 3
    • 40749153470 scopus 로고    scopus 로고
    • Progesterone exerts neuroprotective effects after brain injury
    • Stein DG. Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev 2008; 57: 386-397.
    • (2008) Brain Res Rev , vol.57 , pp. 386-397
    • Stein, D.G.1
  • 7
    • 80051680477 scopus 로고    scopus 로고
    • Progesterone prevents nerve injury-induced allodynia and spinal NMDA receptor upregulation in rats
    • Coronel MF, Labombarda F, Roig P, Villar MJ, De Nicola AF, González SL. Progesterone prevents nerve injury-induced allodynia and spinal NMDA receptor upregulation in rats. Pain Med 2011; 12: 1249-1261.
    • (2011) Pain Med , vol.12 , pp. 1249-1261
    • Coronel, M.F.1    Labombarda, F.2    Roig, P.3    Villar, M.J.4    De Nicola, A.F.5    González, S.L.6
  • 9
    • 0002878362 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and related motor neuron diseases
    • In: Jameson JL, ed. Clifton, NJ: Humana Press
    • Cudkowicz ME, Brown RH. Amyotrophic lateral sclerosis and related motor neuron diseases. In: Jameson JL, ed. Principles of Molecular Medicine. Clifton, NJ: Humana Press, 1998: 907-911.
    • (1998) Principles of Molecular Medicine , pp. 907-911
    • Cudkowicz, M.E.1    Brown, R.H.2
  • 10
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
    • Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med 1994; 330: 585.
    • (1994) N Engl J Med , vol.330 , pp. 585
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 11
    • 0020429617 scopus 로고
    • Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron
    • Mitsumoto H, Bradley WG. Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron. Brain 1982; 105: 811-834.
    • (1982) Brain , vol.105 , pp. 811-834
    • Mitsumoto, H.1    Bradley, W.G.2
  • 12
    • 0642308225 scopus 로고    scopus 로고
    • The wobbler mouse: a neurodegeneration jigsaw puzzle
    • Boillee S, Peschanski M, Junier MP. The wobbler mouse: a neurodegeneration jigsaw puzzle. Mol Neurobiol 2003; 28: 65-106.
    • (2003) Mol Neurobiol , vol.28 , pp. 65-106
    • Boillee, S.1    Peschanski, M.2    Junier, M.P.3
  • 13
    • 58149457372 scopus 로고    scopus 로고
    • Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein
    • Dennis JS, Citron BA. Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein. Neuroscience 2009; 158: 745-750.
    • (2009) Neuroscience , vol.158 , pp. 745-750
    • Dennis, J.S.1    Citron, B.A.2
  • 14
    • 0035756686 scopus 로고    scopus 로고
    • Specific features of chronic astrocyte gliosis after experimental central nervous system (CNS) xenografting and in Wobbler neurological mutant CNS
    • Hantaz-Ambroise D, Jacque C, Ait IA, Parmentier C, Leclerc P, Cambier D, Zadigue G, Rieger F. Specific features of chronic astrocyte gliosis after experimental central nervous system (CNS) xenografting and in Wobbler neurological mutant CNS. Differentiation 2001; 69: 100-107.
    • (2001) Differentiation , vol.69 , pp. 100-107
    • Hantaz-Ambroise, D.1    Jacque, C.2    Ait, I.A.3    Parmentier, C.4    Leclerc, P.5    Cambier, D.6    Zadigue, G.7    Rieger, F.8
  • 16
    • 0025283961 scopus 로고
    • Developmental cell death: morphological diversity and multiple mechanisms
    • Clarke PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990; 181: 195-213.
    • (1990) Anat Embryol (Berl) , vol.181 , pp. 195-213
    • Clarke, P.G.1
  • 17
    • 0035078611 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Wobbler mouse motor neuron disease
    • Tsuzaka KT, Ishiyama EP, Pioro P, Mitsumoto H. Role of brain-derived neurotrophic factor in Wobbler mouse motor neuron disease. Muscle Nerve 2001; 24: 474-480.
    • (2001) Muscle Nerve , vol.24 , pp. 474-480
    • Tsuzaka, K.T.1    Ishiyama, E.P.2    Pioro, P.3    Mitsumoto, H.4
  • 18
    • 0029958252 scopus 로고    scopus 로고
    • Reduction of lower motor neuron degeneration in wobbler mice by n-acetyl-l-cysteine
    • Henderson JT, Javaheri M, Kopko S, Roder JC. Reduction of lower motor neuron degeneration in wobbler mice by n-acetyl-l-cysteine. J Neurosci 1996; 16: 7574-7582.
    • (1996) J Neurosci , vol.16 , pp. 7574-7582
    • Henderson, J.T.1    Javaheri, M.2    Kopko, S.3    Roder, J.C.4
  • 20
    • 0030582411 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase by motor neurons in the spinal cord of the mutant mouse wobble
    • Clowry GJ, McHanwell S. Expression of nitric oxide synthase by motor neurons in the spinal cord of the mutant mouse wobble. Neurosci Lett 1996; 215: 177-180.
    • (1996) Neurosci Lett , vol.215 , pp. 177-180
    • Clowry, G.J.1    McHanwell, S.2
  • 22
    • 1642422748 scopus 로고    scopus 로고
    • Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease
    • Carreras MC, Franco MC, Peralta JG, Poderoso JJ. Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease. Mol Aspects Med 2004; 25: 125-139.
    • (2004) Mol Aspects Med , vol.25 , pp. 125-139
    • Carreras, M.C.1    Franco, M.C.2    Peralta, J.G.3    Poderoso, J.J.4
  • 23
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska MD, Harrison NL, Shwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1981; 232: 1004-1007.
    • (1981) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Shwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 25
    • 40749147175 scopus 로고    scopus 로고
    • The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries
    • Guennoun R, Meffre D, Labombarda F, Gonzalez SL, Deniselle MC, Stein DG, De Nicola AF, Schumacher M. The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Res Rev 2008; 57: 493-505.
    • (2008) Brain Res Rev , vol.57 , pp. 493-505
    • Guennoun, R.1    Meffre, D.2    Labombarda, F.3    Gonzalez, S.L.4    Deniselle, M.C.5    Stein, D.G.6    De Nicola, A.F.7    Schumacher, M.8
  • 26
    • 0028329702 scopus 로고
    • A receptor complex, attenuate pain sensitivity in rats
    • A receptor complex, attenuate pain sensitivity in rats. Brain Res 1994; 643: 194-203.
    • (1994) Brain Res , vol.643 , pp. 194-203
    • Frye, C.A.1    Duncan, J.E.2
  • 28
    • 0037135166 scopus 로고    scopus 로고
    • Methionine-free brain derived neurotrophic factor in wobbler mouse motor neuron disease: dose-related effects and comparison with the methionyl form
    • Ishiyama T, Ogo H, Wong V, Klinkosz B, Noguchi H, Nakayama C, Mitsumoto H. Methionine-free brain derived neurotrophic factor in wobbler mouse motor neuron disease: dose-related effects and comparison with the methionyl form. Brain Res 2002; 944: 195-199.
    • (2002) Brain Res , vol.944 , pp. 195-199
    • Ishiyama, T.1    Ogo, H.2    Wong, V.3    Klinkosz, B.4    Noguchi, H.5    Nakayama, C.6    Mitsumoto, H.7
  • 30
    • 23944445784 scopus 로고    scopus 로고
    • Activity-dependent modulation of BDNF receptor TrkB: mechanisms and implications
    • Nagappan G, Lu B. Activity-dependent modulation of BDNF receptor TrkB: mechanisms and implications. Trends Neurosci 2005; 28: 464-471.
    • (2005) Trends Neurosci , vol.28 , pp. 464-471
    • Nagappan, G.1    Lu, B.2
  • 33
    • 0033997315 scopus 로고    scopus 로고
    • Identification of potential compounds promoting BDNF production in nigral dopaminergic neurons: clinical implications in Parkinson′s disease
    • Chun HS, Son JJ, Son JH. Identification of potential compounds promoting BDNF production in nigral dopaminergic neurons: clinical implications in Parkinson′s disease. NeuroReport 2000; 11: 511-514.
    • (2000) NeuroReport , vol.11 , pp. 511-514
    • Chun, H.S.1    Son, J.J.2    Son, J.H.3
  • 35
    • 0029595287 scopus 로고
    • Immunohistochemical study on choline acetyltransferase in the spinal cord of patients with amyotrophic lateral sclerosis
    • Oda Y, Imai S, Nakanishi I, Ichikawa T, Deguchi T. Immunohistochemical study on choline acetyltransferase in the spinal cord of patients with amyotrophic lateral sclerosis. Pathol Int 1995; 45: 933-939.
    • (1995) Pathol Int , vol.45 , pp. 933-939
    • Oda, Y.1    Imai, S.2    Nakanishi, I.3    Ichikawa, T.4    Deguchi, T.5
  • 38
    • 0043166646 scopus 로고    scopus 로고
    • Early mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouse
    • Dave KR, Bradley WG, Pérez-Pinzón MA. Early mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouse. Exp Neurol 2003; 182: 412-420.
    • (2003) Exp Neurol , vol.182 , pp. 412-420
    • Dave, K.R.1    Bradley, W.G.2    Pérez-Pinzón, M.A.3
  • 39
    • 5144219600 scopus 로고    scopus 로고
    • Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease
    • Santoro B, Bigini P, Levandis G, Nobile V, Biggiogera M, Botti F, Mennini T, Curti D. Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease. Neurobiol Dis 2004; 17: 349-357.
    • (2004) Neurobiol Dis , vol.17 , pp. 349-357
    • Santoro, B.1    Bigini, P.2    Levandis, G.3    Nobile, V.4    Biggiogera, M.5    Botti, F.6    Mennini, T.7    Curti, D.8
  • 44
    • 84886693885 scopus 로고    scopus 로고
    • Predictive value of circulating gonadal and adrenal steroids for respiratory function in patients with amyotrophic lateral sclerosis (ALS)
    • Gargiulo Monachelli G, Sivori M, Meyer M, Sica R, De Nicola AF, Gonzalez Deniselle MC. Predictive value of circulating gonadal and adrenal steroids for respiratory function in patients with amyotrophic lateral sclerosis (ALS). Neurology, 2013; 80: P07.
    • (2013) Neurology , vol.80
    • Gargiulo Monachelli, G.1    Sivori, M.2    Meyer, M.3    Sica, R.4    De Nicola, A.F.5    Gonzalez Deniselle, M.C.6
  • 46
    • 33845755785 scopus 로고    scopus 로고
    • Multiple sclerosis: a battle between destruction and repair
    • McQualter JL, Bernard CC. Multiple sclerosis: a battle between destruction and repair. J Neurochem 2007; 100: 295-306.
    • (2007) J Neurochem , vol.100 , pp. 295-306
    • McQualter, J.L.1    Bernard, C.C.2
  • 47
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008; 31: 247-269.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 48
    • 15944376943 scopus 로고    scopus 로고
    • Multiple sclerosis: novel perspectives on newly forming lesions
    • Matute C, Pérez-Cerdá F. Multiple sclerosis: novel perspectives on newly forming lesions. Trends Neurosci 2005; 28: 173-175.
    • (2005) Trends Neurosci , vol.28 , pp. 173-175
    • Matute, C.1    Pérez-Cerdá, F.2
  • 54
    • 18844429202 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands
    • Elloso MM, Phiel K, Henderson RA, Harris HA, Adelman SJ. Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands. J Endocrinol 2005; 185: 243-244.
    • (2005) J Endocrinol , vol.185 , pp. 243-244
    • Elloso, M.M.1    Phiel, K.2    Henderson, R.A.3    Harris, H.A.4    Adelman, S.J.5
  • 55
    • 77649178742 scopus 로고    scopus 로고
    • Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis
    • Yates MA, Li Y, Chlebeck P, Proctor T, Vandenbark AA, Offner H. Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis. J Neuroimmunol 2010; 220: 136-139.
    • (2010) J Neuroimmunol , vol.220 , pp. 136-139
    • Yates, M.A.1    Li, Y.2    Chlebeck, P.3    Proctor, T.4    Vandenbark, A.A.5    Offner, H.6
  • 56
    • 77952671004 scopus 로고    scopus 로고
    • Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein
    • Yu HJ, Fei J, Chen XS, Cai QY, Liu HL, Liu GD, Yao ZX. Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein. Neurosci Lett 2010; 476: 42-45.
    • (2010) Neurosci Lett , vol.476 , pp. 42-45
    • Yu, H.J.1    Fei, J.2    Chen, X.S.3    Cai, Q.Y.4    Liu, H.L.5    Liu, G.D.6    Yao, Z.X.7
  • 57
    • 84857374216 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration
    • Spence RD, Voskuhl RR. Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol 2012; 33: 105-115.
    • (2012) Front Neuroendocrinol , vol.33 , pp. 105-115
    • Spence, R.D.1    Voskuhl, R.R.2
  • 59
    • 84867304014 scopus 로고    scopus 로고
    • Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis
    • Garay LI, González Deniselle MC, Brocca ME, Lima A, Roig P, De Nicola AF. Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis. Neuroscience 2012; 226: 40-50.
    • (2012) Neuroscience , vol.226 , pp. 40-50
    • Garay, L.I.1    González Deniselle, M.C.2    Brocca, M.E.3    Lima, A.4    Roig, P.5    De Nicola, A.F.6
  • 61
    • 79955745301 scopus 로고    scopus 로고
    • Toll-like receptor signaling in neural plasticity and disease
    • Okun E, Griffioen KJ, Mattson MP. Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci 2011; 34: 269-281.
    • (2011) Trends Neurosci , vol.34 , pp. 269-281
    • Okun, E.1    Griffioen, K.J.2    Mattson, M.P.3
  • 62
    • 80052315340 scopus 로고    scopus 로고
    • Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
    • Hanke ML, Kielian T. Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) 2011; 121: 367-387.
    • (2011) Clin Sci (Lond) , vol.121 , pp. 367-387
    • Hanke, M.L.1    Kielian, T.2
  • 63
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, Nitsch R, Weber JR. A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci 2008; 28: 2320-2331.
    • (2008) J Neurosci , vol.28 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3    Laubisch, D.4    Krueger, C.5    Wulczyn, G.6    Nitsch, R.7    Weber, J.R.8
  • 64
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
    • Selmaj K, Raine CS, Cross AH. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol 1991; 30: 694-700.
    • (1991) Ann Neurol , vol.30 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 65
    • 0029036806 scopus 로고
    • Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones
    • Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Annunziato F, Livi C. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995; 155: 128-133.
    • (1995) J Immunol , vol.155 , pp. 128-133
    • Piccinni, M.P.1    Giudizi, M.G.2    Biagiotti, R.3    Beloni, L.4    Giannarini, L.5    Sampognaro, S.6    Parronchi, P.7    Manetti, R.8    Annunziato, F.9    Livi, C.10
  • 66
    • 33845965027 scopus 로고    scopus 로고
    • Progesterone and its metabolites 5 dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2
    • Muller E, Kerschbaum HH. Progesterone and its metabolites 5 dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2. Neuro Endocrinol Lett 2006; 27: 675-678.
    • (2006) Neuro Endocrinol Lett , vol.27 , pp. 675-678
    • Muller, E.1    Kerschbaum, H.H.2
  • 67
    • 68149124488 scopus 로고    scopus 로고
    • Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-kappaB activation and enhancing SOCS1 expression
    • Su L, Sun Y, Ma F, Lu P, Huang H, Zhou JC. Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-kappaB activation and enhancing SOCS1 expression. Immunol Lett 2009; 125: 151-155.
    • (2009) Immunol Lett , vol.125 , pp. 151-155
    • Su, L.1    Sun, Y.2    Ma, F.3    Lu, P.4    Huang, H.5    Zhou, J.C.6
  • 68
    • 40049104041 scopus 로고    scopus 로고
    • Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion
    • Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, Hang C. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci 2008; 38: 65-74.
    • (2008) Ann Clin Lab Sci , vol.38 , pp. 65-74
    • Chen, G.1    Shi, J.2    Jin, W.3    Wang, L.4    Xie, W.5    Sun, J.6    Hang, C.7
  • 69
    • 0034640064 scopus 로고    scopus 로고
    • Effects of TNFalpha on immature and mature oligodendrocytes and their progenitors in vitro
    • Cammer W. Effects of TNFalpha on immature and mature oligodendrocytes and their progenitors in vitro. Brain Res 2000; 864: 213-219.
    • (2000) Brain Res , vol.864 , pp. 213-219
    • Cammer, W.1
  • 70
    • 79959707104 scopus 로고    scopus 로고
    • Reactive astrocytes inhibit the survival and differentiation of oligodendrocyte precursor cells by secreted TNF-alpha
    • Su Z, Yuan Y, Chen J, Zhu Y, Qiu Y, Zhu F, Huang A, He C. Reactive astrocytes inhibit the survival and differentiation of oligodendrocyte precursor cells by secreted TNF-alpha. J Neurotrauma 2011; 28: 1089-1100.
    • (2011) J Neurotrauma , vol.28 , pp. 1089-1100
    • Su, Z.1    Yuan, Y.2    Chen, J.3    Zhu, Y.4    Qiu, Y.5    Zhu, F.6    Huang, A.7    He, C.8
  • 71
    • 0036121098 scopus 로고    scopus 로고
    • TNF receptor subtype signalling: differences and cellular consequences
    • MacEwan DJ. TNF receptor subtype signalling: differences and cellular consequences. Cell Signal 2002; 14: 477-492.
    • (2002) Cell Signal , vol.14 , pp. 477-492
    • MacEwan, D.J.1
  • 72
    • 4544282704 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
    • He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 2004; 189: 404-412.
    • (2004) Exp Neurol , vol.189 , pp. 404-412
    • He, J.1    Evans, C.O.2    Hoffman, S.W.3    Oyesiku, N.M.4    Stein, D.G.5
  • 73
    • 18144409121 scopus 로고    scopus 로고
    • Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    • Gibson CL, Constantin D, Prior MJ, Bath PM, Murphy SP. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 2005; 193: 522-530.
    • (2005) Exp Neurol , vol.193 , pp. 522-530
    • Gibson, C.L.1    Constantin, D.2    Prior, M.J.3    Bath, P.M.4    Murphy, S.P.5
  • 75
    • 80052264765 scopus 로고    scopus 로고
    • Progesterone attenuates demyelination and microglial reaction in the lysolecithin-injured spinal cord
    • Garay L, Tüngler V, Deniselle MC, Lima A, Roig P, De Nicola AF. Progesterone attenuates demyelination and microglial reaction in the lysolecithin-injured spinal cord. Neuroscience 2011; 192: 588-597.
    • (2011) Neuroscience , vol.192 , pp. 588-597
    • Garay, L.1    Tüngler, V.2    Deniselle, M.C.3    Lima, A.4    Roig, P.5    De Nicola, A.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.