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Volumn 8, Issue 10, 2013, Pages

Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4+ T Cells Are Associated with Increased Susceptibility to Infection

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; GAMMA INTERFERON; MUCIN;

EID: 84886635559     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077568     Document Type: Article
Times cited : (19)

References (65)
  • 3
    • 77956883339 scopus 로고    scopus 로고
    • Interactions between intestinal compounds of triatomines and Trypanosoma cruzi
    • Garcia ES, Genta FA, de Azambuja P, Schaub GA, (2010) Interactions between intestinal compounds of triatomines and Trypanosoma cruzi. Trends Parasitol 26: 499-505.
    • (2010) Trends Parasitol , vol.26 , pp. 499-505
    • Garcia, E.S.1    Genta, F.A.2    de Azambuja, P.3    Schaub, G.A.4
  • 4
    • 79952108690 scopus 로고    scopus 로고
    • The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease
    • Junqueira C, Caetano B, Bartholomeu DC, Melo MB, Ropert C, et al. (2010) The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease. Expert Rev Mol Med 15: 12-29.
    • (2010) Expert Rev Mol Med , vol.15 , pp. 12-29
    • Junqueira, C.1    Caetano, B.2    Bartholomeu, D.C.3    Melo, M.B.4    Ropert, C.5
  • 5
    • 77956209421 scopus 로고    scopus 로고
    • CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance
    • Rosenberg CS, Martin DL, Tarleton RL, (2010) CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance. J Immunol 185: 560-8.
    • (2010) J Immunol , vol.185 , pp. 560-568
    • Rosenberg, C.S.1    Martin, D.L.2    Tarleton, R.L.3
  • 6
    • 70449492771 scopus 로고    scopus 로고
    • Profile of central and effector memory T cells in the progression of chronic human chagas disease
    • Fiuza JA, Fujiwara RT, Gomes JA, Rocha MO, Chaves AT, et al. (2009) Profile of central and effector memory T cells in the progression of chronic human chagas disease. PLoS Negl Trop Dis. 9: 512.
    • (2009) PLoS Negl Trop Dis , vol.9 , pp. 512
    • Fiuza, J.A.1    Fujiwara, R.T.2    Gomes, J.A.3    Rocha, M.O.4    Chaves, A.T.5
  • 7
    • 0035468745 scopus 로고    scopus 로고
    • Clinical and epidemiological aspects of Chagas disease
    • Prata A, (2001) Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92-100.
    • (2001) Lancet Infect Dis , vol.1 , pp. 92-100
    • Prata, A.1
  • 8
    • 0033102525 scopus 로고    scopus 로고
    • Chagas disease etiology: autoimmunity or parasite persistence?
    • Tarleton RL, Zhang L, (1999) Chagas disease etiology: autoimmunity or parasite persistence? Parasitol Today 15: 94-9.
    • (1999) Parasitol Today , vol.15 , pp. 94-99
    • Tarleton, R.L.1    Zhang, L.2
  • 9
    • 0035340666 scopus 로고    scopus 로고
    • Parasite persistence in the aetiology of Chagas disease
    • Review
    • Tarleton RL (2001) Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 3: 550-4. Review.
    • (2001) Int J Parasitol , vol.3 , pp. 550-554
    • Tarleton, R.L.1
  • 10
    • 1142291085 scopus 로고    scopus 로고
    • Chagas disease: a role for autoimmunity?
    • Tarleton RL, (2003) Chagas disease: a role for autoimmunity? Trends Parasitol 19: 447-51.
    • (2003) Trends Parasitol , vol.19 , pp. 447-451
    • Tarleton, R.L.1
  • 11
    • 84859436694 scopus 로고    scopus 로고
    • Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence
    • Fernandes MC, Andrews NW, (2012) Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence. Microbiol Rev 36: 734-47.
    • (2012) Microbiol Rev , vol.36 , pp. 734-747
    • Fernandes, M.C.1    Andrews, N.W.2
  • 14
    • 5044243671 scopus 로고    scopus 로고
    • The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin
    • Alcaide P, Fresno M, (2004) The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin. Int Immunol 16: 1365-75.
    • (2004) Int Immunol , vol.16 , pp. 1365-1375
    • Alcaide, P.1    Fresno, M.2
  • 15
    • 0032902775 scopus 로고    scopus 로고
    • Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes
    • Kierszenbaum F, de Diego JL, Fresno M, Sztein MB, (1999) Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes. Eur J Immunol 29: 1684-91.
    • (1999) Eur J Immunol , vol.29 , pp. 1684-1691
    • Kierszenbaum, F.1    de Diego, J.L.2    Fresno, M.3    Sztein, M.B.4
  • 16
    • 0036861686 scopus 로고    scopus 로고
    • The Trypanosoma cruzi membrane glycoprotein AGC10 inhibits human lymphocyte activation by a mechanism preceding translation of both, interleukin-2 and its high-affinity receptor subunits
    • Kierszenbaum F, Fresno M, Sztein MB, (2002) The Trypanosoma cruzi membrane glycoprotein AGC10 inhibits human lymphocyte activation by a mechanism preceding translation of both, interleukin-2 and its high-affinity receptor subunits. Mol Biochem Parasitol 125: 91-101.
    • (2002) Mol Biochem Parasitol , vol.125 , pp. 91-101
    • Kierszenbaum, F.1    Fresno, M.2    Sztein, M.B.3
  • 17
    • 0036797824 scopus 로고    scopus 로고
    • Trypanosoma cruzi down-regulates lipopolysaccharide-induced MHC class I on human dendritic cells and impairs antigen presentation to specific CD8(+) T lymphocytes
    • Van Overtvelt L, Andrieu M, Verhasselt V, Connan F, Choppin J, et al. (2002) Trypanosoma cruzi down-regulates lipopolysaccharide-induced MHC class I on human dendritic cells and impairs antigen presentation to specific CD8(+) T lymphocytes. Int Immunol 14: 1135-44.
    • (2002) Int Immunol , vol.14 , pp. 1135-1144
    • Van Overtvelt, L.1    Andrieu, M.2    Verhasselt, V.3    Connan, F.4    Choppin, J.5
  • 18
    • 0023264617 scopus 로고
    • Suppressive substance produced by T cells from mice chronically infected with Trypanosoma cruzi. I. Preferential inhibition of the induction of delayed-type hypersensitivity
    • Liew FY, Scott MT, Liu DS, Croft SL, (1987) Suppressive substance produced by T cells from mice chronically infected with Trypanosoma cruzi. I. Preferential inhibition of the induction of delayed-type hypersensitivity. J Immunol 139: 2452-7.
    • (1987) J Immunol , vol.139 , pp. 2452-2457
    • Liew, F.Y.1    Scott, M.T.2    Liu, D.S.3    Croft, S.L.4
  • 19
    • 68149158996 scopus 로고    scopus 로고
    • Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection
    • Padilla AM, Simpson LJ, Tarleton RL, (2009) Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection. J Immunol 183: 1245-52.
    • (2009) J Immunol , vol.183 , pp. 1245-1252
    • Padilla, A.M.1    Simpson, L.J.2    Tarleton, R.L.3
  • 21
    • 62949232674 scopus 로고    scopus 로고
    • Cyclic AMP decreases the production of NO and CCL2 by macrophages stimulated with Trypanosoma cruzi GPI-mucins
    • Talvani A, Coutinho SF, Barcelos Lda S, Teixeira MM, (2009) Cyclic AMP decreases the production of NO and CCL2 by macrophages stimulated with Trypanosoma cruzi GPI-mucins. Parasitol Res 104: 1141-8.
    • (2009) Parasitol Res , vol.104 , pp. 1141-1148
    • Talvani, A.1    Coutinho, S.F.2    Barcelos Lda, S.3    Teixeira, M.M.4
  • 22
    • 1642525756 scopus 로고    scopus 로고
    • Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
    • Campos MA, Closel M, Valente EP, Cardoso JE, Akira S, et al. (2004) Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172: 1711-8.
    • (2004) J Immunol , vol.172 , pp. 1711-1718
    • Campos, M.A.1    Closel, M.2    Valente, E.P.3    Cardoso, J.E.4    Akira, S.5
  • 23
    • 0034012169 scopus 로고    scopus 로고
    • Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies
    • Pereira-Chioccola VL, Acosta-Serrano A, Correia de Almeida I, Ferguson MA, Souto-Padron T, et al. (2000) Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies. J Cell Sci 113: 1299-307.
    • (2000) J Cell Sci , vol.113 , pp. 1299-1307
    • Pereira-Chioccola, V.L.1    Acosta-Serrano, A.2    Correia de Almeida, I.3    Ferguson, M.A.4    Souto-Padron, T.5
  • 24
    • 0031573627 scopus 로고    scopus 로고
    • Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages
    • Camargo MM, Andrade AC, Almeida IC, Travassos LR, Gazzinelli RT, (1997) Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages. J Immunol 159: 6131-9.
    • (1997) J Immunol , vol.159 , pp. 6131-6139
    • Camargo, M.M.1    Andrade, A.C.2    Almeida, I.C.3    Travassos, L.R.4    Gazzinelli, R.T.5
  • 25
    • 0028820596 scopus 로고
    • The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells
    • Di Noia JM, Sánchez DO, Frasch AC, (1995) The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells. J Biol Chem 270: 24146-9.
    • (1995) J Biol Chem , vol.270 , pp. 24146-24149
    • Di Noia, J.M.1    Sánchez, D.O.2    Frasch, A.C.3
  • 26
    • 84884592083 scopus 로고    scopus 로고
    • Addition of α-O-GlcNAc to threonine residues define the post-translational modification of mucin-like molecules in Trypanosoma cruzi
    • Mendonça-Previato L, Penha L, Garcez TC, Jones C, Previato JO (2013) Addition of α-O-GlcNAc to threonine residues define the post-translational modification of mucin-like molecules in Trypanosoma cruzi. Glycoconj J Feb 21.
    • (2013) Glycoconj J , vol.21
    • Mendonça-Previato, L.1    Penha, L.2    Garcez, T.C.3    Jones, C.4    Previato, J.O.5
  • 28
    • 79959930795 scopus 로고    scopus 로고
    • Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite
    • Giorgi ME, de Lederkremer RM, (2011) Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite. Carbohydr Res 346: 1389-93.
    • (2011) Carbohydr Res , vol.346 , pp. 1389-1393
    • Giorgi, M.E.1    de Lederkremer, R.M.2
  • 29
    • 0025769326 scopus 로고
    • A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells
    • Schenkman S, Jiang MS, Hart GW, Nussenzweig V, (1991) A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 65: 1117-25.
    • (1991) Cell , vol.65 , pp. 1117-1125
    • Schenkman, S.1    Jiang, M.S.2    Hart, G.W.3    Nussenzweig, V.4
  • 30
    • 0028958148 scopus 로고
    • Structural characterization of the major glycosylphosphatidylinositol membrane-anchored glycoprotein from epimastigote forms of Trypanosoma cruzi Y-strain
    • Previato JO, Jones C, Xavier MT, Wait R, Travassos LR, et al. (1995) Structural characterization of the major glycosylphosphatidylinositol membrane-anchored glycoprotein from epimastigote forms of Trypanosoma cruzi Y-strain. J Biol Chem 270: 7241-50.
    • (1995) J Biol Chem , vol.270 , pp. 7241-7250
    • Previato, J.O.1    Jones, C.2    Xavier, M.T.3    Wait, R.4    Travassos, L.R.5
  • 31
    • 84876849492 scopus 로고    scopus 로고
    • Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes
    • Nardy AF, Luiz da Silva Filho J, Pérez AR, de Meis J, Farias-de-Oliveira DA, et al. (2013) Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes Infect 15: 365-74.
    • (2013) Microbes Infect , vol.15 , pp. 365-374
    • Nardy, A.F.1    Luiz da Silva Filho, J.2    Pérez, A.R.3    de Meis, J.4    Farias-de-Oliveira, D.A.5
  • 32
    • 33745039985 scopus 로고    scopus 로고
    • The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation
    • Mucci J, Risso MG, Leguizamón MS, Frasch AC, Campetella O, (2006) The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation. Cell Microbiol 8: 1086-95.
    • (2006) Cell Microbiol , vol.8 , pp. 1086-1095
    • Mucci, J.1    Risso, M.G.2    Leguizamón, M.S.3    Frasch, A.C.4    Campetella, O.5
  • 33
    • 72749104617 scopus 로고    scopus 로고
    • Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E)
    • Erdmann H, Steeg C, Koch-Nolte F, Fleischer B, Jacobs T, (2009) Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E). Cell Microbiol 11: 1600-11.
    • (2009) Cell Microbiol , vol.11 , pp. 1600-1611
    • Erdmann, H.1    Steeg, C.2    Koch-Nolte, F.3    Fleischer, B.4    Jacobs, T.5
  • 34
    • 0028916615 scopus 로고
    • Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease
    • Chuenkova M, Pereira ME, (1995) Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease. J Exp Med 181: 1693-703.
    • (1995) J Exp Med , vol.181 , pp. 1693-1703
    • Chuenkova, M.1    Pereira, M.E.2
  • 35
    • 77956266766 scopus 로고    scopus 로고
    • Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation
    • Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, et al. (2010) Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 20: 833-42.
    • (2010) Glycobiology , vol.20 , pp. 833-842
    • Muiá, R.P.1    Yu, H.2    Prescher, J.A.3    Hellman, U.4    Chen, X.5
  • 36
    • 84876532051 scopus 로고    scopus 로고
    • Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
    • Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, et al. (2013) Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. Nat Immunol 14: 514-22.
    • (2013) Nat Immunol , vol.14 , pp. 514-522
    • Bermejo, D.A.1    Jackson, S.W.2    Gorosito-Serran, M.3    Acosta-Rodriguez, E.V.4    Amezcua-Vesely, M.C.5
  • 37
    • 73649148004 scopus 로고    scopus 로고
    • Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi
    • Jacobs T, Erdmann H, Fleischer B, (2010) Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi. Eur J Cell Biol 89: 113-6.
    • (2010) Eur J Cell Biol , vol.89 , pp. 113-116
    • Jacobs, T.1    Erdmann, H.2    Fleischer, B.3
  • 38
    • 84859416185 scopus 로고    scopus 로고
    • Multifarious roles of sialic acids in immunity
    • Varki A, Gagneux P, (2012) Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci 1253: 16-36.
    • (2012) Ann N Y Acad Sci , vol.1253 , pp. 16-36
    • Varki, A.1    Gagneux, P.2
  • 39
  • 41
    • 3843145244 scopus 로고    scopus 로고
    • The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils
    • Zhang JQ, Biedermann B, Nitschke L, Crocker PR, (2004) The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils. Eur J Immunol 34: 1175-84.
    • (2004) Eur J Immunol , vol.34 , pp. 1175-1184
    • Zhang, J.Q.1    Biedermann, B.2    Nitschke, L.3    Crocker, P.R.4
  • 42
    • 0035252999 scopus 로고    scopus 로고
    • mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2
    • Yu Z, Maoui M, Wu L, Banville D, Shen S, (2001) mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J 353: 483-92.
    • (2001) Biochem J , vol.353 , pp. 483-492
    • Yu, Z.1    Maoui, M.2    Wu, L.3    Banville, D.4    Shen, S.5
  • 44
    • 0027080364 scopus 로고
    • The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells
    • Marks DC, Belov L, Davey MW, Davey RA, Kidman AD, (1992) The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells. Leuk Res 16: 1165-73.
    • (1992) Leuk Res , vol.16 , pp. 1165-1173
    • Marks, D.C.1    Belov, L.2    Davey, M.W.3    Davey, R.A.4    Kidman, A.D.5
  • 45
    • 33749516648 scopus 로고    scopus 로고
    • Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression
    • Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, et al. (2006) Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol 177: 5024-31.
    • (2006) J Immunol , vol.177 , pp. 5024-5031
    • Charvet, C.1    Canonigo, A.J.2    Bécart, S.3    Maurer, U.4    Miletic, A.V.5
  • 46
    • 84867602759 scopus 로고    scopus 로고
    • Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia
    • Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, et al. (2012) Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell 22: 452-65.
    • (2012) Cancer Cell , vol.22 , pp. 452-465
    • Sawai, C.M.1    Freund, J.2    Oh, P.3    Ndiaye-Lobry, D.4    Bretz, J.C.5
  • 47
    • 84869762838 scopus 로고    scopus 로고
    • p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory
    • Jatzek A, Tejera MM, Singh A, Sullivan JA, Plisch EH, et al. (2012) p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. J Immunol 189: 5119-28.
    • (2012) J Immunol , vol.189 , pp. 5119-5128
    • Jatzek, A.1    Tejera, M.M.2    Singh, A.3    Sullivan, J.A.4    Plisch, E.H.5
  • 48
    • 0019475195 scopus 로고
    • Enzymatic treatment transforms trypomastigotes of Trypanosoma cruzi into activators of alternative complement pathway and potentiates their uptake by macrophages
    • Kipnis TL, David JR, Alper CA, Sher A, da Silva WD, (1991) Enzymatic treatment transforms trypomastigotes of Trypanosoma cruzi into activators of alternative complement pathway and potentiates their uptake by macrophages. Proc Natl Acad Sci U S A 78: 602-5.
    • (1991) Proc Natl Acad Sci U S A , vol.78 , pp. 602-605
    • Kipnis, T.L.1    David, J.R.2    Alper, C.A.3    Sher, A.4    da Silva, W.D.5
  • 49
    • 0022977997 scopus 로고
    • Evasion of alternative complement pathway by Trypanosoma cruzi results from inefficient binding of factor B
    • Joiner K, Sher A, Gaither T, Hammer C, (1986) Evasion of alternative complement pathway by Trypanosoma cruzi results from inefficient binding of factor B. Proc Natl Acad Sci U S A. 83: 6593-7.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 6593-6597
    • Joiner, K.1    Sher, A.2    Gaither, T.3    Hammer, C.4
  • 50
    • 0025733449 scopus 로고
    • Direct lysis of Trypanosoma cruzi: a novel effector mechanism of protection mediated by human anti-gal antibodies
    • Gazzinelli RT, Pereira ME, Romanha A, Gazzinelli G, Brener Z, (1991) Direct lysis of Trypanosoma cruzi: a novel effector mechanism of protection mediated by human anti-gal antibodies. Parasite Immunol 13: 345-56.
    • (1991) Parasite Immunol , vol.13 , pp. 345-356
    • Gazzinelli, R.T.1    Pereira, M.E.2    Romanha, A.3    Gazzinelli, G.4    Brener, Z.5
  • 51
    • 84880279165 scopus 로고    scopus 로고
    • Tumor Immunomodulation: Mucins in resistance to initiation and maturation of immune response against tumors
    • Jan 9
    • Anandkumar A, Devaraj H (2013) Tumor Immunomodulation: Mucins in resistance to initiation and maturation of immune response against tumors. Scand J Immunol Jan 9.
    • (2013) Scand J Immunol
    • Anandkumar, A.1    Devaraj, H.2
  • 52
    • 79953281969 scopus 로고    scopus 로고
    • Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages
    • Allavena P, Chieppa M, Bianchi G, Solinas G, Fabbri M, et al. (2010) Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages. Clin Dev Immunol 547179.
    • (2010) Clin Dev Immunol
    • Allavena, P.1    Chieppa, M.2    Bianchi, G.3    Solinas, G.4    Fabbri, M.5
  • 53
    • 79953155667 scopus 로고    scopus 로고
    • Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
    • Freire T, Lo-Man R, Bay S, Leclerc C, (2011) Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. J Biol Chem 11: 7797-811.
    • (2011) J Biol Chem , vol.11 , pp. 7797-7811
    • Freire, T.1    Lo-Man, R.2    Bay, S.3    Leclerc, C.4
  • 54
    • 78649445696 scopus 로고    scopus 로고
    • Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9
    • Ohta M, Ishida A, Toda M, Akita K, Inoue M, et al. (2010) Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9. Biochem Biophys Res Commun 402: 663-9.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 663-669
    • Ohta, M.1    Ishida, A.2    Toda, M.3    Akita, K.4    Inoue, M.5
  • 55
    • 51549099068 scopus 로고    scopus 로고
    • MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma
    • Tinder TL, Subramani DB, Basu GD, Bradley JM, Schettini J, et al. (2008) MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. J Immunol 181: 3116-25.
    • (2008) J Immunol , vol.181 , pp. 3116-3125
    • Tinder, T.L.1    Subramani, D.B.2    Basu, G.D.3    Bradley, J.M.4    Schettini, J.5
  • 57
    • 80052670103 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection
    • Cuervo H, Guerrero NA, Carbajosa S, Beschin A, De Baetselier P, et al. (2011) Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection. J Immunol 187: 2656-65.
    • (2011) J Immunol , vol.187 , pp. 2656-2665
    • Cuervo, H.1    Guerrero, N.A.2    Carbajosa, S.3    Beschin, A.4    De Baetselier, P.5
  • 59
    • 0037369744 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection modulates in vivo expression of major histocompatibility complex class II molecules on antigen-presenting cells and T-cell stimulatory activity of dendritic cells in a strain-dependent manner
    • Alba Soto CD, Mirkin GA, Solana ME, González Cappa SM, (2003) Trypanosoma cruzi infection modulates in vivo expression of major histocompatibility complex class II molecules on antigen-presenting cells and T-cell stimulatory activity of dendritic cells in a strain-dependent manner. Infect Immun 71: 1194-9.
    • (2003) Infect Immun , vol.71 , pp. 1194-1199
    • Alba Soto, C.D.1    Mirkin, G.A.2    Solana, M.E.3    González Cappa, S.M.4
  • 60
    • 0034016495 scopus 로고    scopus 로고
    • Trypanosoma cruzi-induced immunosuppression: B cells undergo spontaneous apoptosis and lipopolysaccharide (LPS) arrests their proliferation during acute infection
    • Zuñiga E, Motran C, Montes CL, Diaz FL, Bocco JL, et al. (2000) Trypanosoma cruzi-induced immunosuppression: B cells undergo spontaneous apoptosis and lipopolysaccharide (LPS) arrests their proliferation during acute infection. Clin Exp Immunol. 119: 507-15.
    • (2000) Clin Exp Immunol , vol.119 , pp. 507-515
    • Zuñiga, E.1    Motran, C.2    Montes, C.L.3    Diaz, F.L.4    Bocco, J.L.5
  • 61
    • 0029986558 scopus 로고    scopus 로고
    • Mechanisms of Trypanosoma cruzi-induced down-regulation of lymphocyte function. Inhibition of transcription and expression of IL-2 receptor gamma (p64IL-2R) and beta (p70IL-2R) chain molecules in activated normal human lymphocytes
    • Majumder S, Kierszenbaum F, (1996) Mechanisms of Trypanosoma cruzi-induced down-regulation of lymphocyte function. Inhibition of transcription and expression of IL-2 receptor gamma (p64IL-2R) and beta (p70IL-2R) chain molecules in activated normal human lymphocytes. J Immunol 156: 3866-74.
    • (1996) J Immunol , vol.156 , pp. 3866-3874
    • Majumder, S.1    Kierszenbaum, F.2
  • 62
    • 0029935407 scopus 로고    scopus 로고
    • Trypanosoma cruzi-induced immunosuppression: selective triggering of CD4+ T-cell death by the T-cell receptor-CD3 pathway and not by the CD69 or Ly-6 activation pathway
    • Lopes MF, DosReis GA, (1996) Trypanosoma cruzi-induced immunosuppression: selective triggering of CD4+ T-cell death by the T-cell receptor-CD3 pathway and not by the CD69 or Ly-6 activation pathway. Infect Immun 64: 1559-64.
    • (1996) Infect Immun , vol.64 , pp. 1559-1564
    • Lopes, M.F.1    DosReis, G.A.2
  • 63
    • 0029098304 scopus 로고
    • Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection
    • Abrahamsohn IA, Coffman RL, (1995) Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J Immunol 155: 3955-63.
    • (1995) J Immunol , vol.155 , pp. 3955-3963
    • Abrahamsohn, I.A.1    Coffman, R.L.2
  • 64
    • 0026697737 scopus 로고
    • Selective suppressive effects of Trypanosoma cruzi infection on IL-2, c-myc, and c-fos gene expression
    • Soong L, Tarleton RL, (1992) Selective suppressive effects of Trypanosoma cruzi infection on IL-2, c-myc, and c-fos gene expression. J Immunol 149: 2095-102.
    • (1992) J Immunol , vol.149 , pp. 2095-2102
    • Soong, L.1    Tarleton, R.L.2
  • 65
    • 65349133663 scopus 로고    scopus 로고
    • Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
    • Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, et al. (2009) Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood 113: 3333-6.
    • (2009) Blood , vol.113 , pp. 3333-3336
    • Carlin, A.F.1    Uchiyama, S.2    Chang, Y.C.3    Lewis, A.L.4    Nizet, V.5


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