Trypanosoma crazi-induced immunosuppression: Selective triggering of CD4+ T-cell death by the T-cell receptor-CD3 pathway and not by the CD69 or Ly-6 activation pathway

Infection and Immunity

Volumn 64, Issue 5, 1996, Pages 1559-1564

  Lopes, Marcela F ^a   Dosreis, George A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CHAGAS DISEASE; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, LY; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; DISEASE MODELS, ANIMAL; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; TRYPANOSOMA CRUZI;

EID: 0029935407     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.5.1559-1564.1996     Document Type: Article

References (34)

1. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections; the role of apoptosis in T cell memory. J. Exp. Med. 178:427-438.
2. Beltz, L. A., M. B. Sztein, and F. Kierszenbaum. 1988. Novel mechanism for Trypanosoma cruzi-induced suppression of human lymphocytes: inhibition of IL-2 receptor expression. J. Immunol. 141:289-294.
3. - T cells during murine AIDS. Cell. Immunol. 151:392-403.
4. Contreras, V. T., J. M. Salles, N. Thomas, C. M. Morel, and S. Goldenberg. 1985. In vitro differentiation of Trypanosoma cruzi under chemically defined conditions. Mol. Biochem. Parasitol. 16:315-327.
5. Dias, J. C. P. 1992. In S. Wendel, Z. Brener, M. E. Camargo, and A. Rassi (ed.), Chagas disease: its impact on transfusion and clinical medicine, p. 49. ISBT Brazil '92. Cartgraf Editora Ltda, Campinas, Brazil.
6. DosReis, G. A., M. E. F. Fonseca, and M. F. Lopes. 1995. Programmed T-cell death in experimental Chagas disease. Parasitol. Today 11:390-394.
7. Dutra, W. O., O. A. Martins-Filho, J. R. Cançado, J. C. Pinto-Dias, Z. Brener, G. L. Freeman, Jr., D. G. Colley, G. Gazzinelli, and J. C. Parra. 1994. Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease. Int. Immunol. 6:499-506.
8. Harel-Bellan, A., M. Joskowicz, D. Fradelizi, and H. Eisen. 1985 T lymphocyte function during experimental Chagas disease: production of and response to interleukin 2. Eur. J. Immunol. 15:438-442.
9. Kierszenbaum, F. 1981 On evasion of Trypanosoma cruzi from the host immune response Lymphoproliferative responses to trypanosomal antigens during acute and chrome experimental Chagas' disease. Immunology 44: 641-648.
10. Kubo, R. T., W. Born, J. W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736-2742.
11. Kyburz, D., P. Aichele, D. E. Speiser, H. Hengartner, R. M. Zinkernagel, and H. Pircher. 1993. T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J Immunol 23:1956-1962.
12. Lenardo, M. J. 1991. Interleukin 2 programs mouse αβ T lymphocytes for apoptosis. Nature (London) 353:858-861.
13. Leo, O., M. Foo, D. H. Sachs, L. H. Samelson, and J. A. Bluestone. 1987 Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl. Acad. Sci. USA 84:1374-1377.
14. Lopes, M. F., J. M. T. Cunha, F. L. Bezerra, M. S. Gonzalez, J. E. L. Gomes, J. R. Lapa e Silva, E. S. Garcia, and G. A. DosReis. 1995. Trypanosoma cruziboth chemically induced and triatomine derived mctacyclic trypomastigotes cause the same immunological disturbances in the infected mammalian host. Exp. Parasitol. 80:194-204
15. Lopes, M. F., and G. A. DosReis. 1994. Trypanosoma crazi-induced immunosuppression: blockade of costimulatory T cell responses in infected hosts due to defective T-cell receptor-CD3 functioning Infect. Immun. 62:1484-1488
16. Lopes, M. F., V. F. Veiga, A. R. Santos, M. E. F. Fonseca, and G. A. DosReis. 1995. Activation-induced CD4+ T cell death by apoptosis in experimental Chagas disease. J. Immunol 154:744-752.
17. Malek, T. R., G. Ortega, C. Chan, R. A. Kroczek, and E. M. Shevach. 1986. Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies. J. Exp Med. 164:709-722.
18. Minoprio, P., H. Eisen, L. Forni, M. R. D'Imperio Lima, M. Joskowicz, and A. Coutinho. 1986. Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T-and B-cell responses. Scand. J. Immunol. 24:661-668.
19. Minoprio, P., S. Itohara, C. Heusser, S. Tonegawa, and A. Continho. 1989. Immunobiology of murme T cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCR I T cells. Immunol. Rev. 112:184-206.
20. Moretta, A., A. Poggi, D. Pende, G. Tripodi, A. M. Orengo, N. Pella, R. Augugliaro, C. Bottino, E. Ciccone, and L. Moretta. 1991. CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolylic T lymphocytes expressing T cell receptor α/β. J. Exp Med. 174: 1393-1398.
21. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (London) 362:758-761.
22. Nóbrega, A. F., G. A. DosReis, and R. Fucs. 1990 Naturally activated and resting T cells differ in their activation requirements for growth and secretory activities. Cell. Immunol. 125:120-129.
23. Petry, K., and H. Eisen. 1989. Chagas disease: a model for the study of autoimmune diseases. Parasitol. Today 5:111-116.
24. Ramos, C. E., M. Lamoy, M. Feoli, M. Rodriguez, M. Perez, and L. Ortiz-Ortiz. 1978. Trypanosoma cruzi: immunosuppressed response to different antigens in the infected mouse. Exp. Parasitol. 45:190-199
25. Razvi, E. S., and R. M. Welsh. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency. J Virol. 67:5754-5765.
26. Reed, S. G., J. A. Inverso, and S. B. Roters. 1984. Heterologous antibody responses in mice with T. cruzi infection depressed T helper function restored with supernatants containing interleukin-2. J. Immunol. 133:1558-1563.
27. Reed, S. G., C. L. Larson, and C. A. Speer. 1977. Suppression of cell-mediated immunity in experimental Chagas' disease. Z. Parasitenkd. 52: 11-17.
28. Sanders, M. E., M. W. Makgoba, C. H. June, H. A. Young, and S. Shaw. 1989. Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur. J. Immunol. 19:803-808.
29. Sussman, J. J., T. Saito, E. M. Shevach, R. N. Germain, and J. D. Ashwell. 1988. Thy-1-and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex. J. Immunol 140:2520-2526
30. Tarleton, R. L. 1988. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. J. Immunol 140:2769-2773.
31. Tarleton, R. L., B. H. Kohler, A. Latour, and M. Postan. 1992. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature (London) 356:338-341.
32. Tarleton, R. L., and R. E. Kuhn. 1984. Restoration of in vitro immune responses of spleen cells from mice infected with Trypanosoma cruzi by supernatants containing interleukin-2. J Immunol 133:1570-1575.
33. Teixeira, A. R. L., G. Teixeira, V. Macedo, and A. Prata. 1978. Acquired cell-mediated immunodepression in acute Chagas disease. J. Clin. Invest. 62: 1132-1141.
34. Yokoyama, W. M., S. R. Maxfield, and E. M. Shevach. 1989. Very early (VEA) and very late (VLA) activation antigens have distinct functions in T lymphocyte activation. Immunol. Rev. 169:153-176.