Acute lung injury in preterm fetuses and neonates: Mechanisms and molecular pathways

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 26, Issue 17, 2013, Pages 1696-1704

  Iliodromiti, Zoe ^a   Zygouris, Dimitrios ^b   Sifakis, Stavros ^c   Pappa, Kalliopi I ^b   Tsikouras, Panagiotis ^d   Salakos, Nikolaos ^a   Daniilidis, Angelos ^e   Siristatidis, Charalambos ^b   Vrachnis, Nikolaos ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^d DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Acute lung injury; Inflammation; Preterm neonates; Reactive nitrogen species; Reactive oxygen species

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ACUTE LUNG INJURY; ARTICLE; CHORIOAMNIONITIS; CLINICAL FEATURE; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; EPITHELIUM CELL; GROWTH RATE; HUMAN; HYPEROXIA; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; VENTILATOR INDUCED LUNG INJURY;

ACUTE LUNG INJURY; FEMALE; FETAL DISEASES; FETUS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LUNG; PREGNANCY; PREMATURE BIRTH; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 84886627398     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2013.798284     Document Type: Article

References (85)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-49.
2. Fanaroff AA, Stoll BJ, Wright LL, et al. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol 2007;196:147 e1-8.
3. Li Y, Wang Q, Chen H, et al. Epidemiological features and risk factor analysis of children with acute lung injury. World J Pediatr 2012;8:43-6.
4. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-9.
5. Bland RD. Neonatal chronic lung disease in the post-surfactant era. Biol Neonate 2005;88:181-91.
6. Speer CP. New insights into the pathogenesis of pulmonary inflammation in preterm infants. Biol Neonate 2001;79:205-9.
7. Chakraborty M, McGreal EP, Kotecha S. Acute lung injury in preterm newborn infants: Mechanisms and management. Paediatr Respir Rev 2010;11:162-70.
8. O'Reilly MA. DNA damage and cell cycle checkpoints in hyperoxic lung injury: Braking to facilitate repair. Am J Physiol Lung Cell Mol Physiol 2001;281:L291-305.
9. Schittny JC, Djonov V, Fine A, Burri PH. Programmed cell death contributes to postnatal lung development. Am J Respir Cell Mol Biol 1998;18:786-93.
10. Viscardi RM, Muhumuza CK, Rodriguez A, et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Res 2004;55:1009-17.
11. Goepfert AR, Andrews WW, Carlo W, et al. Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity. Am J Obstet Gynecol 2004;191:1375-81.
12. Kotecha S, Mildner RJ, Prince LR, et al. The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. Thorax 2003;58:961-7.
13. Hanna N, Vasquez P, Pham P, et al. Mechanisms underlying reduced apoptosis in neonatal neutrophils. Pediatr Res 2005;57: 56-62.
14. Koenig JM, Stegner JJ, Schmeck AC, et al. Neonatal neutrophils with prolonged survival exhibit enhanced inflammatory and cytotoxic responsiveness. Pediatr Res 2005;57:424-9.
15. Gunther A, Siebert C, Schmidt R, et al. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am J Respir Crit Care Med 1996;153: 176-84.
16. Vrachnis N, Vitoratos N, Iliodromiti Z, et al. Intrauterine inflammation and preterm delivery. Ann N Y Acad Sci 2010;1205: 118-22.
17. Malamitsi-Puchner A, Vrachnis N, Samoli E, et al. Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid. Ann N Y Acad Sci 2006;1092:440-9.
18. Maxwell NC, Davies PL, Kotecha S. Antenatal infection and inflammation: What's new? Curr Opin Infect Dis 2006;19:253-8.
19. Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996;97:210-15.
20. Coalson JJ. Pathology of new bronchopulmonary dysplasia. Semin Neonatol 2003;8:73-81.
21. Gomez R, Romero R, Ghezzi F, et al. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202.
22. Yoon BH, Romero R, Jun JK, et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-Alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1997;177:825-30.
23. Been JV, Zimmermann LJ. Histological chorioamnionitis and respiratory outcome in preterm infants. Arch Dis Child Fetal Neonatal Ed 2009;94:F218-25.
24. West JB, Mathieu-Costello O. Stress failure of pulmonary capillaries: Role in lung and heart disease. Lancet 1992;340:762-7.
25. Parker JC, Hernandez LA, Peevy KJ. Mechanisms of ventilatorinduced lung injury. Crit Care Med 1993;21:131-43.
26. Slutsky AS. Lung injury caused by mechanical ventilation. Chest 1999;116:9S-15S.
27. Dreyfuss D, Saumon G. Ventilator-induced lung injury: Lessons from experimental studies. Am J Respir Crit Care Med 1998;157: 294-323.
28. Hillman NH, Polglase GR, Pillow JJ, et al. Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011;300:L232-41.
29. Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159-64.
30. Kotecha S. Cytokines in chronic lung disease of prematurity. Eur J Pediatr 1996;155:S14-7.
31. Tremblay L, Valenza F, Ribeiro SP, et al. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997;99:944-52.
32. Kinsella JP, Abman SH. Inhaled nitric oxide in the premature newborn. J Pediatr 2007;151:10-15.
33. Warner BB, Stuart LA, Papes RA, Wispe Jr. Functional and pathological effects of prolonged hyperoxia in neonatal mice. Am J Physiol 1998;275:L110-17.
34. Barazzone C, White CW. Mechanisms of cell injury and death in hyperoxia: Role of cytokines and Bcl-2 family proteins. Am J Respir Cell Mol Biol 2000;22:517-19.
35. Horowitz S. Pathways to cell death in hyperoxia. Chest 1999;116: 64S-7S.
36. Thickett DR, Armstrong L, Christie SJ, Millar AB. Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164:1601-5.
37. Saugstad OD. Bronchopulmonary dysplasia-oxidative stress and antioxidants. Semin Neonatol 2003;8:39-49.
38. Jobe AH, Ikegami M. Mechanisms initiating lung injury in the preterm. Early Hum Dev 1998;53:81-94.
39. Kramer BW, Kallapur S, Newnham J, Jobe AH. Prenatal inflammation and lung development. Semin Fetal Neonatal Med 2009;14: 2-7.
40. Jobe AJ. The new BPD: An arrest of lung development. Pediatr Res 1999;46:641-3.
41. Jones CA, Cayabyab RG, Kwong KY, et al. Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: A possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res 1996;39:966-75.
42. Yoon BH, Romero R, Kim KS, et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999;181:773-9.
43. Agrawal A, Zhuo H, Brady S, et al. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: Results from two clinical trials. Am J Physiol Lung Cell Mol Physiol 2012;303:L634-9.
44. Matsuda T, Nakajima T, Hattori S, et al. Necrotizing funisitis: Clinical significance and association with chronic lung disease in premature infants. Am J Obstet Gynecol 1997;177: 1402-7.
45. Hitti J, Krohn MA, Patton DL, et al. Amniotic fluid tumor necrosis factor-Alpha and the risk of respiratory distress syndrome among preterm infants. Am J Obstet Gynecol 1997;177:50-6.
46. Barton L, Hodgman JE, Pavlova Z. Causes of death in the extremely low birth weight infant. Pediatrics 1999;103:446-51.
47. Little S, Dean T, Bevin S, et al. Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic lung disease in premature infants. Thorax 1995;50: 1073-9.
48. Ramsay PL, O'Brian Smith E, Hegemier S, Welty SE. Early clinical markers for the development of bronchopulmonary dysplasia: Soluble E-Selectin and ICAM-1. Pediatrics 1998;102: 927-32.
49. Kallapur SG, Jobe AH, Ikegami M, Bachurski CJ. Increased IP-10 and MIG expression after intra-Amniotic endotoxin in preterm lamb lung. Am J Respir Crit Care Med 2003;167:779-86.
50. Kallapur SG, Bachurski CJ, Le Cras TD, et al. Vascular changes after intra-Amniotic endotoxin in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol 2004;287:L1178-85.
51. Kunzmann S, Speer CP, Jobe AH, Kramer BW. Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs. Am J Physiol Lung Cell Mol Physiol 2007;292: L223-31.
52. Willet KE, Jobe AH, Ikegami M, et al. Antenatal endotoxin and glucocorticoid effects on lung morphometry in preterm lambs. Pediatr Res 2000;48:782-8.
53. Janer J, Lassus P, Haglund C, et al. Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants. Am J Respir Crit Care Med 2006;174:326-30.
54. Su JL, Shih JY, Yen ML, et al. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C upregulation: A novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res 2004;64:554-64.
55. Lassus P, Wolff H, Andersson S. Cyclooxygenase-2 in human perinatal lung. Pediatr Res 2000;47:602-5.
56. Sapru A, Curley MA, Brady S, et al. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med 2010;36:157-63.
57. Markos J, Doerschuk CM, English D, et al. Effect of positive endexpiratory pressure on leukocyte transit in rabbit lungs. J Appl Physiol 1993;74:2627-33.
58. Matsuoka T, Kawano T, Miyasaka K. Role of high-frequency ventilation in surfactant-depleted lung injury as measured by granulocytes. J Appl Physiol 1994;76:539-44.
59. Tsuchida S, Engelberts D, Roth M, et al. Continuous positive airway pressure causes lung injury in a model of sepsis. Am J Physiol Lung Cell Mol Physiol 2005;289:L554-64.
60. Capoluongo E, Vento G, Santonocito C, et al. Comparison of serum levels of seven cytokines in premature newborns undergoing different ventilatory procedures: High frequency oscillatory ventilation or synchronized intermittent mandatory ventilation. Eur Cytokine Netw 2005;16:199-205.
61. Hillman NH, Nitsos I, Berry C, et al. Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011;301:L712-20.
62. Grande JP. Role of transforming growth factor-beta in tissue injury and repair. Proc Soc Exp Biol Med 1997;214:27-40.
63. Bartram U, Speer CP. The role of transforming growth factor beta in lung development and disease. Chest 2004;125:754-65.
64. Sime PJ, Marr RA, Gauldie D, et al. Transfer of tumor necrosis factor-Alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol 1998;153: 825-32.
65. Aikio O, Vuopala K, Pokela ML, Hallman M. Diminished inducible nitric oxide synthase expression in fulminant early-onset neonatal pneumonia. Pediatrics 2000;105:1013-19.
66. Bagchi A, Viscardi RM, Taciak V, et al. Increased activity of interleukin-6 but not tumor necrosis factor-Alpha in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia. Pediatr Res 1994;36:244-52.
67. Tan ND, Davidson D. Comparative differences and combined effects of interleukin-8, leukotriene B4, and platelet-Activating factor on neutrophil chemotaxis of the newborn. Pediatr Res 1995; 38:11-16.
68. Biffl WL, Moore EE, Moore FA, et al. Interleukin-6 potentiates neutrophil priming with platelet-Activating factor. Arch Surg 1994; 129:1131-6.
69. Meredith KS, deLemos RA, Coalson JJ, et al. Role of lung injury in the pathogenesis of hyaline membrane disease in premature baboons. J Appl Physiol 1989;66:2150-8.
70. Johnston CJ, Wright TW, Reed CK, Finkelstein JN. Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia. Exp Lung Res 1997;23:537-52.
71. Bhandari V, Elias JA. Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. Free Radic Biol Med 2006; 4:4-18.
72. Coalson JJ, Winter VT, Siler-Khodr T, Yoder BA. Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999;160:1333-46.
73. Thiel M, Chouker A, Ohta A, et al. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol 2005;3:e174.
74. Lindsay L, Oliver SJ, Freeman SL, et al. Modulation of hyperoxia-induced TNF-Alpha expression in the newborn rat lung by thalidomide and dexamethasone. Inflammation 2000;24:347-56.
75. Deng H, Mason SN, Auten Jr RL. Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Am J Respir Crit Care Med 2000;162:2316-23.
76. D'Angio CT, LoMonaco MB, Chaudhry SA, et al. Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbit. Exp Lung Res 1999;25:443-65.
77. Mura M, dos Santos CC, Stewart D, Liu M. Vascular endothelial growth factor and related molecules in acute lung injury. J Appl Physiol 2004;97:1605-17.
78. Bhandari V. Hyperoxia-derived lung damage in preterm infants. Semin Fetal Neonatal Med 2010;15:223-9.
79. Ben-Ari J, Makhoul IR, Dorio RJ, et al. Cytokine response during hyperoxia: Sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats. Isr Med Assoc J 2000;2: 365-9.
80. Dasgupta C, Sakurai R, Wang Y, et al. Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone. Am J Physiol Lung Cell Mol Physiol 2009;296:L1031-41.
81. Alejandre-Alcazar MA, Kwapiszewska G, Reiss I, et al. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 2007;292:L537-49.
82. Nakanishi H, Sugiura T, Streisand JB, et al. TGF-beta-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung. Am J Physiol Lung Cell Mol Physiol 2007;293:L151-61.
83. Willson DF, Notter RH. The future of exogenous surfactant therapy. Respir Care 2011;56:1369-86, discussion 1386-8.
84. Vosdoganes P, Lim R, Moss TJ, Wallace EM. Cell therapy: A novel treatment approach for bronchopulmonary dysplasia. Pediatrics 2012;130:727-37.
85. Valentine SL, Sapru A, Higgerson RA, et al. Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network; Acute Respiratory Distress Syndrome Clinical Research Network (ARDSNet). Fluid balance in critically ill children with acute lung injury. Crit Care Med 2012;40:2883-9.