The involvement of KATP channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats

Fundamental and Clinical Pharmacology

Volumn 27, Issue 6, 2013, Pages 623-631

  Afify, Elham A ^a,b   Khedr, Mohamed M ^c   Omar, Amal G ^a,c   Nasser, Suzanne A ^c  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c BEIRUT ARAB UNIVERSITY   (Lebanon)

Author keywords

Antinociception; Diazoxide; Glibenclamide; KATP channels; Morphine; Oxidative stress; Pain tests

Indexed keywords

DIAZOXIDE; FORMALDEHYDE; GLIBENCLAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MORPHINE; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG ANTAGONISM; DRUG MECHANISM; DRUG POTENTIATION; INFLAMMATORY PAIN; LIVER HOMOGENATE; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PAIN; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

ANTINOCICEPTION; DIAZOXIDE; GLIBENCLAMIDE; KATP CHANNELS; MORPHINE; OXIDATIVE STRESS; PAIN TESTS;

ACUTE PAIN; ANALGESICS, OPIOID; ANIMALS; DIAZOXIDE; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLYBURIDE; INFLAMMATION; KATP CHANNELS; LIVER; MALE; MALONDIALDEHYDE; MORPHINE; OXIDATIVE STRESS; PAIN; PAIN MEASUREMENT; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84886598239     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/fcp.12004     Document Type: Article

References (46)

1. Thompson A., Ray J. The importance of opioid tolerance: a therapeutic paradox. J. Am. Coll. Surg. (2003) 196 321-324.
2. + channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides. Eur. J. Pharmacol. (1999) 385 119-127.
3. + channels. Br. J. Pharmacol. (2000) 129 110-114.
4. Ocaña A.M. Potassium channels and pain: present realities and future opportunities. Eur. J. Pharmacol. (2004) 500 203-219.
5. Narita M., Takamori K., Kawashima N. et al. Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice. Psychopharmacology (1993) 113 11-14.
6. 2-adrenergic agonists in rats. Anesth. Analg. (2000) 90 1146-1151.
7. Yang S., Kang Y., Guo Y., Qiao J., Dafny N. ATP-sensitive potassium channels mediate norepinephrine- and morphine-induced antinociception at the spinal cord level. Int. J. Neurosci. (2000) 93 217-223.
8. ATP channel. Am. J. Physiol. Heart Circ. Physiol. (2003) 284 H299-H308.
9. Wei E., Kontos H., Beckman J. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am. J. Physiol. (1996) 271 H1262-H1266.
10. Liu S., Beckman J., Ku D. Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs. J. Pharmacol. Exp. Ther. (1994) 268 1114-1121.
11. Zhang Y., Zheng Q., Pan J., Zheng R. Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants. Basic Clin. Pharmacol. Toxicol. (2004) 95 53-58.
12. William S., Sekar N., Subramanian S., Govindasamy S. Toxic effect of morphine and the antagonistic role of naloxone on isolated rat hepatocytes. Biochem. Int. (1991) 23 1071-1077.
13. Panchenko L., Pirozhkov S., Nadezhdin A., Baronets V., Usmanova N. Lipid peroxidation, peroxyl radical-scavenging system of plasma and liver and heart pathology in adolescence heroin users. Vopr. Med. Khim. (1999) 45 501-564.
14. Amteshwar S., Vivek J., Nirmal S. Animal models of neuropathic pain. Fundam. Clin. Pharmacol. (2011) 25 1-28.
15. Curatolo M., Petersen S., Arende L. Sensory assessment of regional analgesia in humans; a review of methods and applications. Anesthesiology (2000) 93 1517-1530.
16. McPherson B., Yao Z. Morphine mimics preconditioning via free radical signals and mitochondrial KATP channels in myocytes. Circulation (2001) 103 290-295.
17. Patel H., Hsu A., Peart J., Gross G. Sarcolemmal KATP channel triggers opioid-induced delayed cardioprotection in the rat. Circ. Res. (2002) 91 186-188.
18. Coderre T., Rollman G. Naloxone hyperalgesia and stress-induced analgesia in rats. Life Sci. (1983) 32 2139-2146.
19. Goudas L., Carr D., Marchand J., Wurm W., Greenblatt D., Kream R. Central and peripheral glutathione after morphine or ketamine compartmental responses (Abstract) 14th annual scientific meeting. American Pain Society (1995) A-152.
20. Campos A., Santos F., Rao S. Ketamine-induced potentiation of morphine analgesia in rat tail-flick test: role of opioid-, α2-adrenoceptors and ATP-sensitive potassium channels. Biol. Pharm. Bull. (2006) 29 86-89.
21. Galeotti N., Ghelardini C., Vinci M., Bartolini A. Role of potassium channels in the antinociception induced by agonists of α2-adrenoceptors. Br. J. Pharmacol. (1999) 126 1214-1220.
22. Wheeler-Aceto H., Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology (1991) 104 35-44.
23. Richardson R.J., Murphy S.D. Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol. Appl. Pharmacol. (1975) 31 505-519.
24. Chiu D.T., Stults F.H., Tappel A.L. Purification and properties of rat lung soluble glutathione peroxidase. Biochim. Biophys. Acta (1976) 445 558-566.
25. Mihara M., Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. (1978) 86 271-278.
26. Ocaña M., Barrios M., Baeyens J.M. Cromakalim differentially enhances antinociception induced by agonists of alpha(2) adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors. J. Pharmacol. Exp. Ther. (1996) 276 1136-1142.
27. Vergoni A., Scarano A., Bertolini A. Pinacidil potentiates morphine analgesia. Life Sci. (1992) 50 PL135-PL138.
28. Picolo G., Cassola A.C., Cury Y. Activation of peripheral ATP-sensitive K+ channels mediates the antinociceptive effect of Crotalus durissus terrificus snake venom. Eur. J. Pharmacol. (2003) 469 57-64.
29. Khallizadeh O., Anvari M., Kallizadeh A., Sahebgharani M., Zarrindast M.R. Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice. Int. J. Neurosci. (2008) 118 503-518.
30. Welch S., Dunlow L. Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: a common mechanism of action? J. Pharmacol. Exp. Ther. (1993) 267 390-399.
31. Khanna N., Malhotra R.S., Mehta A.K., Garg G.R., Halder S., Sharma K.K. Interaction of morphine and potassium channel openers on experimental models of pain in mice. Fundam. Clin. Pharmacol. (2011) 25 479-484.
32. Calcutt N. Modeling diabetic sensory neuropathy in rats. Methods Mol. Med. (2004) 99 55-65.
33. Hunskaar S., Fasmer O., Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods (1985) 14 69-76.
34. Puig S., Sorkin L.S. Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain (1996) 64 345-355.
35. Dickenson A., Sullivan A. Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones. Neurosci. Lett. (1987) 83 207-211.
36. Eisenhut M., Wallace H. Ion channels in inflammation. Pflugers Arch. (2011) 461 401-421.
37. Ocaña A.M., Del Pozo E., Barrios M., Robles L.L., Baeyens J.M. An ATP-dependent potassium channel blocker antagonizes morphine analgesia. Eur. J. Pharmacol. (1990) 186 377-378.
38. + -channel openers, diazoxide and cromakalim. J. Pharmacol. Exp. Ther. (1989) 250 261-270.
39. Wiertelak E.P., Furness L.E., Horan R., Martinez J., Maier S.F., Watkins L.R. Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade. Brain Res. (1994) 649 19-26.
40. Shi L., Smolders I., Sarre S., Michotte Y., Zizi M., Camu F. Formalin-induced spinal glutamate release in freely moving rats: comparison of two spinal microdialysis approaches. Acta Anaesthesiol. Belg. (2004) 55 43-48.
41. Lafon-Cazal M., Culcasi M., Gaven F., Pietri S., Bockaert J. Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar cells. Neuropharmacology (1993) 32 1259-1266.
42. Reynolds I., Hastings T. Glutamate induces production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. (1995) 15 3318-3327.
43. Liu D., Pitta M., Lee J.H. et al. The KATP channel activator diazoxide ameliorates amyloid-B and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J. Alzheimers Dis. (2010) 22 443-457.
44. Rokyta R., Holecek V., Pekarkova I. et al. Free radicals after painful stimulation are influenced by antioxidants and analgesics. Neuro Endocrinol. Lett. (2003) 24 304-309.
45. Landstedt-Hallin L., Adamson U., Lins P.E. Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. (1999) 84 3140-3145.
46. Patockova J., Marhol P., Tumova E. et al. Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia. Physiol. Res. (2003) 52 131-135.