Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties

International Journal of Biochemistry and Cell Biology

Volumn 38, Issue 12, 2006, Pages 2074-2081

  Bhat, Showket Hussain ^a   Azmi, Asfar Sohail ^a   Hanif, Sarmad ^a   Hadi, S M ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Ascorbic acid; Comet assay; Endogenous copper; Prooxidant action

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; ANTIOXIDANT; ASCORBIC ACID; COPPER ION; DNA; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPOTHESIS; OBSERVATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PLANT; QUANTITATIVE ANALYSIS; UPREGULATION;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; COMET ASSAY; COPPER; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICAL SCAVENGERS; HUMANS; HYDROGEN PEROXIDE; LYMPHOCYTES; NEOPLASMS; OXIDANTS; OXIDATION-REDUCTION; PHENANTHROLINES; TANNINS;

ANIMALIA;

EID: 33748766854     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2006.05.017     Document Type: Article

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