Molecular changes in invasive front of oral cancer

Journal of Oral and Maxillofacial Pathology

Volumn 17, Issue 2, 2013, Pages 240-247

  Sharma, Mohit ^a   Sah, Parul ^b   Sharma, Sonal ^a   Radhakrishnan, Raghu ^b  

^a INSTITUTE OF DENTAL SCIENCES   (India)

^b MANIPAL COLLEGE OF DENTAL SCIENCES   (India)

Author keywords

Head and neck; invasive front; molecular markers; squamous cell carcinoma

Indexed keywords

EID: 84886524092     PISSN: 0973029X     EISSN: 1998393X     Source Type: Journal    
DOI: 10.4103/0973-029X.119740     Document Type: Review

References (81)

1. Broder AC. Carcinoma of the mouth: Types and degrees of malignancy. Am J Roentgenol Radium Ther Nucl Med 1927;17:90-3
2. Bryne M, Nielsen K, Koppang HS, Dabelsteen E. Reproducibility of two malignancy grading systems with reportedly prognostic value for oral cancer patients. J Oral Pathol Med 1991;20:369-72
3. Umeda M, Nishimatsu N, Teranobu O, Shimada K. Criteria for diagnosing lymph node metastasis from squamous cell carcinoma of oral cavity study of relationship between computed tomographic and histologic findings and outcome. J Oral Maxillofac Surg 1998;56:585-93
4. Giacomarra V, Tirelli G, Papanikolla L, Bussani R. Predictive factors of nodal metastasis in oral cavity and oropharynx carcinomas. Laryngoscope 1999;109:795-9
5. Willen R, Nathanson A, Moberger G, Anneroth G. Squamous cell carcinoma of the gingiva. Histological classification and grading of malignancy. Acta Otolaryngol 1975;79:146-54
6. Anneroth G, Batsakis J, Luna M. Review of literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scan J Dent Res 1987;95:229-49
7. Piffko J, Bánkfalvi A, Ofner D, Rasch D, Joos U, Schmid KW. Standardized demonstration of silver-stained nucleolar organizer regions-associated proteins in archival oral squamous cell carcinomas and adjacent non-neoplastic mucosa. Mod Pathol 1997;10:98-104
8. Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication. Oral Dis 1998;4:70-7
9. Bankfalvi A, Piffko J. Prognostic and predictive factors in oral cancer: The role of invasive tumor front. J Oral Pathol Med 2000;29:291-8
10. Welkoborsky HJ, Gluckman JL, Jacob R, Bernauer H, Mann W. Tumor biologic prognostic parameters in T1N0M0 squamous cell carcinoma of the oral cavity. Laryngorhinootologie 1999;78:131-8
11. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol 1992;166:375-81
12. Noguchi M, Kinjyo H, Kohama GI, Nakamori K. Invasive front in oral squamous cell carcinoma: Image and ow cytometric analysis with clinicopathologic correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:682-7
13. Kurokawa H, Zhang M, Matsumoto S, Yamashita S, Tanaka T, Tomoyose H, et al. The relationship of the histologic grade at the deep invasive front and the expression of Ki-67 antigen and p53 protein in oral squamous cell carcinoma. J Oral Pathol Med 2005;34:602-7
14. Haas M, Berndt A, Hyckel P, Stiller KJ, Kosmehl H. Laminin-5 in diseases of the oral cavity. Mund Kiefer Gesichtschir 2000;4:25-9
15. Harada T, Shinohara M, Nakamura S, Oka M. An immunohistochemical study of the extracellular matrix in oral squamous cell carcinoma and its association with invasive and metastatic potential. Virchows Arch 1994;424:257-66
16. Kosmehl H, Berndt A, Strassburger S, Borsi L, Rousselle P, Mandel U, et al. Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma. Br J Cancer 1999;81:1071-9
17. Berndt A, Borsi L, Hyckel P, Kosmehl H. Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro. J Cancer Res Clin Oncol 2001;127:286-92
18. Patel V, Aldridge K, Ensley JF, Odell E, Boyd A, Jones J, et al. Laminin-gamma 2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer 2002;99:583-8
19. Kulasekara KK, Lukandu OM, Neppelberg E, Vintermyr OK, Johannessen AC, Costea DE. Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer. Arch Oral Biol 2009;54:924-31
20. Wilson DF, Jiang D, Pierce AM, Wiebkin OW. Oral cancer: Role of the basement membrane in invasion. Aust Dent J 1999;44:93-7
21. Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong H, et al. Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons. Mol Cancer Res 2009;7:311-8
22. Aznavoorian S, Murphy AN, Stetler-Stevenson WG, Liotta LA. Molecular aspects of tumor cell invasion and metastasis. Cancer 1993;71:1368-83
23. Marinkovich MP. Laminin 332 in squamous-cell carcinoma. Nat Rev Cancer 2007;7:370-80
24. Franz M, Richter P, Geyer C, Hansen T, Acuna LD, Hyckel P, et al. Mesenchymal cells contribute to the synthesis and deposition of the laminin-5 gamma2 chain in the invasive front of oral squamous cell carcinoma. J Mol Histol 2007;38:183-90
25. Lindberg P, Larsson A, Nielsen BS. Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin 2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer 2006;118:2948-56
26. Franz M, Hansen T, Borsi L, Geier C, Hyckel P, Schleier P, et al. A quantitative co-localization analysis of large unspliced tenascin-C (L) and laminin-5/gamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy. J Oral Pathol Med 2007;36:6-11
27. Franz M, Hansen T, Richter P, Borsi L, Bohmer FD, Hyckel P, et al. Complex formation of the laminin-5, gamma2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: Implications for sequential modulation of extracellular matrix in the invasive tumor front. Histochem Cell Biol 2006;126:125-31
28. Jones PL, Jones FS. Tenascin-C in development and disease: Gene regulation and cell function. Matrix Biol 2000;19:581-96
29. Huang W, Chiquet-Ehrismann R, Moyano JV, Garcia-Pardo A, Orend G. Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation. Cancer Res 2001;61:8586-94
30. Tiitta O, Happonen RP, Virtanen I, Luomanen M. Distribution of tenascin in oral premalignant lesions and squamous cell carcinoma. J Oral Pathol Med 1994;23:446-50
31. Shrestha P, Sakamoto F, Takagi H, Yamada T, Mori M. Enhanced tenascin immunoreactivity in leukoplakia and squamous cell carcinoma of the oral cavity: An immunohistochemical study. Eur J Cancer B Oral Oncol 1994;30:132-7
32. Mori M, Muramatsu Y, Yamada K, Shrestha P, Takai Y. Intracellular localization of tenascin in squamous cell carcinoma of oral cavity: An immunohistochemical study. Anticancer Res 1996;16:3075-9
33. Hindermann W, Berndt A, Borsi L, Luo X, Hyckel P, Katenkamp D, et al. Synthesis and protein distribution of the unspliced large tenascin-C isoform in oral squamous cell carcinoma. J Pathol 1999;189:475-80
34. Inki P, Jalkanen M. The role of syndecan-1 in malignancies. Ann Med 1996;28:63-7
35. Ro Y, Muramatsu T, Shima K, Yajima Y, Shibahara T, Noma H, et al. Correlation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue. Int J Oral Maxillofac Surg 2006;35:252-7
36. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tanaka T, Takamori K, et al. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. J Oral Pathol Med 2006;35:301-6
37. Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer 2005;5:29-41
38. Chiang WF, Liu SY, Fang LY, Lin CN, Wu MH, Chen YC, et al. Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. Oral Oncol 2008;44:325-34
39. Sahai E, Marshall CJ. Rho-GTPases and cancer. Nat Rev Cancer 2002;2:133-42
40. Yamazaki D, Kurisu S, Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci 2005;96:379-86
41. Ruoslathi E. Fibronectin and its receptors. Annu Rev Biochem 1988;57:375-413
42. Clark ES, Weaver AM. A new role for cortactin in invadopodia: Regulation of protease secretion. Eur J Cell Biol 2008;87:581-90
43. Clark ES, Whigham AS, Yarbrough WG, Weaver AM. Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res 2007;67:4227-35
44. Williams ME, Gaffey MJ, Weiss LM. Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 1993;119:1238-43
45. Yamada S, Yanamoto S, Kawasaki G, Mizuno A, Nemoto TK. Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma. Pathol Oncol Res 2010;4:523-31
46. Bánkfalvi A, Krassort M, Buchwalow IB, Vegh A, Felszeghy E, Piffko J. Gains and losses of adhesion molecules (CD44, E-cadherin, and beta-catenin) during oral carcinogenesis and tumour progression. J Pathol 2002;198:343-51
47. Fonseca LM, do Carmo MA. AgNORs in hyperplasia, papilloma and oral squamous cell carcinoma. Braz Dent J 2000;11:105-10
48. Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell 2010;141:52-67
49. Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-Beta and promotes tumor invasion and angiogenesis. Genes Dev 2000;14:163-76
50. Wang X, Zhang J, Fan M, Zhou Q, Deng H, Aisharif MJ. The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: Immunohistochemical and RT-PCR analysis with clinicopathological correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:547-54
51. Lo ML, Staibano S, Pannone G, Grieco M, Mignogna MD, Cerrato A, et al. Beta-and gamma-catenin expression in oral squamous cell carcinomas. Anticancer Res 1999;19:3817-26
52. Ohara T, Kawashiri S, Tanaka A, Noguchi N, Kitahara H, Okamune A, et al. Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma. Pathol Oncol Res 2009;15:429-36
53. Thomas GJ, Jones J, Speight PM. Integrins and oral cancer. Oral Oncol 1997;33:381-8
54. Hamidi S, Salo T, Kainulainen T, Epstein J, Lerner K, Larjava H. Expression of alpha (v) beta 6 integrin in oral leukoplakia. Br J Cancer 2000;82:1433-40
55. Thomas GJ, Jones J, Speight PM. Matrix metalloproteinases and oral cancer. Oral Oncol 1999;35:227-33
56. Kurahara S, Shinohara M, Ikebe T, Nakamura S, Beppu M, Hiraki A, et al. Expression of MMPs, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis. Head Neck 1999;21:627-38
57. Hadler-Olsen E, Wetting HL, Ravuri C, Omair A, Rikardsen O, Svineng G, et al. Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front. Eur J Cancer 2011;47:305-15
58. Sutinen M, Kainulainen T, Hurskainen T, Vesterlund E, Alexander JP, Overall CM, et al. Expression of matrix metalloproteinases (MMP-1 and-2) and their inhibitors (TIMP-1,-2 and-3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Br J Cancer 1998;77:2239-45
59. O-Charoenrat P, Rhys-Evans PH, Eccles SA. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2001;127:813-20
60. Katayama A, Bandoh N, Kishibe K, Takahara M, Ogino T, Nonaka S, et al. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin Can Res 2004;10:634-40
61. de Vicente JC, Fresno MF, Villalain L, Vega JA, Lopez Arranz JS. Immunoexpression and prognostic significance of TIMP-1 and-2 in oral squamous cell carcinoma. Oral Oncol 2005;41:568-79
62. Ondruschka C, Buhtz P, Motsch C, Freigang B, Scheneider-Stock R, Roessner A, et al. Prognostic value of MMP-2,-9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas. Pathol Res Pract 2002;198:509-15
63. Yamamoto N, Mizoe Je, Numasawa H, Tsujii H, Shibahara T, Noma H. Allelic loss on chromosomes 2q, 3p and 21q: Possibly a poor prognostic factor in oral squamous cell carcinoma. Oral Oncol 2003;39:796-805
64. Partridge M, Emilion G, Pateromichelakis S, A'Hern R, Lee G, Phillips E, et al. The prognostic signicance of allelic imbalance at key chromosomal loci in oral cancer. Br J Cancer 1999;79:1821-7
65. Wang XH, Fan MW, Sun ZJ, Chen XM, Wang L, Li Y. The TP53 and RPS6 alterations at the invasive tumor front, center and stroma of oral squamous cell carcinoma. Zhonghua Kou Qiang Yi Xue Za Zhi 2007;42:140-3
66. Day GL, Blot WJ, Shore RE, McLaughlin JK, Austin DF, Greenberg RS, et al. Second cancers following oral and pharyngeal cancers: Role of tobacco and alcohol. J Natl Cancer Inst 1994;86:131-7
67. Shintani S, Li C, Ishikawa T, Mihara M, Nakashiro K, Hamakawa H. Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma. Oral Oncol 2004;40:13-20
68. Richter P, Umbreit C, Franz M, Berndt A, Grimm S, Uecker A. EGF/TGF1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332. J Oral Pathol Med 2011;40:46-54
69. Tang S, Xu D, Zhou B. Analysis of P53 mutation and invasion front grading in oral squamous cell carcinomas. J Huazhong Univ Sci Technolog Med Sci 2010;30:525-9
70. Kato K, Kawashiri S, Tanaka A, Noguchi N, Nakaya H, Hase T, et al. Predictive value of measuring p53 labeling index at the invasive front of oral squamous cell carcinomas. Pathol Oncol Res 2008;14:57-61
71. Horta MC, de Assis LA, de Souza AF, de Araujo VC, Gomez RS, Aquiar MC. p53 and p21WAF1/CIP1 overexpression at the invasive front of lower lip squamous cell carcinoma. J Oral Pathol Med 2007;36:88-92
72. Piffkò J, Bànkfalvi A, Tory K, Fuzesi L, Bryne M, Ofner D, et al. Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas. Head Neck 1998;20:8-15
73. Tumuluri V, Thomas GA, Fraser IS. The relationship of proliferating cell density at the invasive tumor front with prognostic and risk factors in human oral squamous cell carcinomas. J Oral Pathol Med 2004;33:204-8
74. Piffkó J, Bánkfalvi A, Ofner D, Kusch F, Bocker W, Joos U, et al. In situ assessment of cell proliferation at the invasive front of oral squamous cell carcinomas. Virchows Arch 1996;429:229-34
75. Myoung H, Kim MJ, Lee JH, Ok YJ, Paeng JY, Yun PY. Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: A clinical and histopathological analysis of 113 patients. Int J Oral Maxillofac Surg 2006;35:1005-10
76. Dissanayake U, Johnson NW, Warnakulasuriya KA. Comparison of cell proliferation in the centre and advancing fronts of oral squamous cell carcinomas using Ki-67 index. Cell Prolif 2003;36:255-64
77. Kobayashi I, Matsuo K, Ozeki S, Ohishi M, Ishibashi Y, Sakai H. The proliferative activity in oral epithelial dysplasia analyzed by proliferating cell nuclear antigen immunostaining and argyrophilic nucleolar organizer region staining. Human Pathol 1995;26:907-13
78. Wang XH, Wang SZ, Chen XM, Li Y. The study of proliferation of cells at the invasive tumor front of squamous cell carcinoma of tongue. Zhonghua Kou Qiang Yi Xue Za Zhi 2004;39:49-52
79. Watanabe S, Watanabe R, Oton-Leite AF, Alencar Rde C, Oliveira JC, Leles CR, et al. Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma. J Oral Sci 2010;52:417-24
80. Dong H, Bertler C, Schneider E, Ritter MA. Assessment of cell proliferation by AgNOR scores and Ki-67 labeling indices and a comparison with potential doubling times. Cytometry 1997;28:280-8
81. Piffko J, Bankfalvi A, Öfner D, Rasch D, Joos U, Schmid KW. Standardized AgNOR analysis of the invasive tumour front in oral squamous cell carcinomas. J Pathol 1997;182:450-6