TRPV4 channel activation leads to endothelium-dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery

Pharmacological Research

Volumn 78, Issue , 2013, Pages 18-27

  Sukumaran, Susanth V ^a   Singh, Thakur Uttam ^a   Parida, Subhashree ^a   Narasimha Reddy, Ch E ^a   Thangamalai, Ramasamy ^a   Kandasamy, Kannan ^a   Singh, Vishakha ^a   Mishra, Santosh Kumar ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Endothelium; Endothelium derived hyperpolarizing factor; Nitric oxide; Pulmonary artery; Relaxation; TRPV4 channels

Indexed keywords

GSK 1016790A; HC 067047; INDOMETACIN; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR AGONIST; VANILLOID RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTERY TONE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; HYPERPOLARIZATION; MALE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; RAT; SMOOTH MUSCLE RELAXATION; VASODILATATION;

1-[(2-CHLOROPHENYL)DIPHENYLMETHYL]-1H-PYRAZOLE; 1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE; 4Α-PDD; 4Α-PHORBOL-12,13-DIDECANOATE; ACETYLCHOLINE; ACH; ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANOVA; ATP; DIMETHYL SULPHOXIDE; DMSO; ECS; EDHF; EET; ENDOTHELIAL CELLS; ENDOTHELIUM; ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR; EPOXYEICOSATRIENOIC ACIDS; GSK; GSK1016790A; IK(CA); INTERMEDIATE CONDUCTANCE POTASSIUM CHANNEL; L-NAME; MKHS; MODIFIED KREBS-HENSELEIT SOLUTION; N(G)-NITRO-L-ARGININE METHYL ESTER; NITRIC OXIDE; NO; ODQ; PCR; PE; PHENYLEPHRINE; POLYMERASE CHAIN REACTION; PULMONARY ARTERY; RELAXATION; SGC; SK(CA); SMALL CONDUCTANCE POTASSIUM CHANNEL; SNP; SODIUM NITROPRUSSIDE; SOLUBLE GUANYLYL CYCLASE; TRAM 34; TRANSIENT RECEPTOR POTENTIAL VANILLOID 4; TRPV4; TRPV4 CHANNELS;

ANIMALS; BIOLOGICAL FACTORS; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; MALE; NITRIC OXIDE; PULMONARY ARTERY; RATS; RATS, WISTAR; TRPV CATION CHANNELS; VASODILATION;

EID: 84886481927     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.09.005     Document Type: Article

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